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Article: Effects of lung inflation on nasal airway resistance in the anesthetized rat

TitleEffects of lung inflation on nasal airway resistance in the anesthetized rat
Authors
Issue Date1987
Citation
Journal Of Applied Physiology, 1987, v. 63 n. 4, p. 1339-1343 How to Cite?
AbstractNasal airway resistance was assessed in halothane-anesthetized rats by measuring the transnasal pressure at constant airflow through both nasal cavities. Low inflation pressure (2.5-5 cm H2O) decreased nasal airway resistance, whereas higher inflation pressures (10-20 cm H2O) caused a biphasic response: an initial increase in resistance followed by decrease in resistance. The nasal responses to all levels of inflation where completely abolished by hexamethonium, guanethidine, or bretylium pretreatment or cervical sympathectomy and greatly lessened by cervical vagotomy or phenoxybenzamine pretreatment. Atropine and propranolol pretreatments had no effect on the responses. The findings indicate that the nasal airway resistance is related to the level of inflation through pulmonary reflexes with afferents along the vagi and efferents via the α-adrenergic nervous system.
Persistent Identifierhttp://hdl.handle.net/10722/171513
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLung, MAen_US
dc.date.accessioned2012-10-30T06:15:29Z-
dc.date.available2012-10-30T06:15:29Z-
dc.date.issued1987en_US
dc.identifier.citationJournal Of Applied Physiology, 1987, v. 63 n. 4, p. 1339-1343en_US
dc.identifier.issn0161-7567en_US
dc.identifier.urihttp://hdl.handle.net/10722/171513-
dc.description.abstractNasal airway resistance was assessed in halothane-anesthetized rats by measuring the transnasal pressure at constant airflow through both nasal cavities. Low inflation pressure (2.5-5 cm H2O) decreased nasal airway resistance, whereas higher inflation pressures (10-20 cm H2O) caused a biphasic response: an initial increase in resistance followed by decrease in resistance. The nasal responses to all levels of inflation where completely abolished by hexamethonium, guanethidine, or bretylium pretreatment or cervical sympathectomy and greatly lessened by cervical vagotomy or phenoxybenzamine pretreatment. Atropine and propranolol pretreatments had no effect on the responses. The findings indicate that the nasal airway resistance is related to the level of inflation through pulmonary reflexes with afferents along the vagi and efferents via the α-adrenergic nervous system.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Applied Physiologyen_US
dc.subject.meshAirway Resistance - Drug Effectsen_US
dc.subject.meshAnesthesiaen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshFemaleen_US
dc.subject.meshLung - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNose - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshSympathectomyen_US
dc.subject.meshVagotomyen_US
dc.titleEffects of lung inflation on nasal airway resistance in the anesthetized raten_US
dc.typeArticleen_US
dc.identifier.emailLung, MA:makylung@hkucc.hku.hken_US
dc.identifier.authorityLung, MA=rp00319en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3693166-
dc.identifier.scopuseid_2-s2.0-0023543173en_US
dc.identifier.volume63en_US
dc.identifier.issue4en_US
dc.identifier.spage1339en_US
dc.identifier.epage1343en_US
dc.identifier.isiWOS:A1987K495100004-
dc.identifier.scopusauthoridLung, MA=7006411781en_US

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