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Article: Lung reflexes and nasal vascular resistance in the anaesthetized dog

TitleLung reflexes and nasal vascular resistance in the anaesthetized dog
Authors
Issue Date1987
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3751
Citation
Journal Of Physiology, 1987, v. Vol. 386, p. 465-474 How to Cite?
AbstractIn pentobarbitone-anaesthetized dogs the nasal vasculature was perfused on both sides, and nasal vascular and airflow resistances were measured together with blood pressure, heart rate and tidal airflow. Capsaicin was injected intravenously to stimulate lung C-fibre receptors, and veratrine to stimulate pulmonary stretch receptors and cardiac receptors. Injections with both drugs were repeated after pulmonary denervation and after cervical vagosympathectomy. Intravenous capsaicin caused hypotension, bradycardia and rapid shallow breathing, together with a decrease in nasal vascular resistance and little change in nasal airways resistance. Denervation showed that these effects came from lung reflexes, presumably from C-fibre receptors. Intravenous veratrine caused similar effects to capsaicin before denervations, presumably due to stimulation of slowly adapting pulmonary stretch receptors. Left atrial injections of veratrine caused hypertension, bradycardia and hyperpnoea, together with an increase in nasal vascular resistance and little change in nasal airways resistance. Thus cardiac receptors seem to increase nasal vascular resistance. Injections of capsaicin and veratrine into the nasal circulation decreased nasal vascular resistance, with a stimulation of breathing and changes in blood pressure. Denervations indicated that these were a combination of local and reflex actions.
Persistent Identifierhttp://hdl.handle.net/10722/171507
ISSN
2015 Impact Factor: 4.731
2015 SCImago Journal Rankings: 2.670
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLung, MAen_US
dc.contributor.authorWiddicombe, JGen_US
dc.date.accessioned2012-10-30T06:15:28Z-
dc.date.available2012-10-30T06:15:28Z-
dc.date.issued1987en_US
dc.identifier.citationJournal Of Physiology, 1987, v. Vol. 386, p. 465-474en_US
dc.identifier.issn0022-3751en_US
dc.identifier.urihttp://hdl.handle.net/10722/171507-
dc.description.abstractIn pentobarbitone-anaesthetized dogs the nasal vasculature was perfused on both sides, and nasal vascular and airflow resistances were measured together with blood pressure, heart rate and tidal airflow. Capsaicin was injected intravenously to stimulate lung C-fibre receptors, and veratrine to stimulate pulmonary stretch receptors and cardiac receptors. Injections with both drugs were repeated after pulmonary denervation and after cervical vagosympathectomy. Intravenous capsaicin caused hypotension, bradycardia and rapid shallow breathing, together with a decrease in nasal vascular resistance and little change in nasal airways resistance. Denervation showed that these effects came from lung reflexes, presumably from C-fibre receptors. Intravenous veratrine caused similar effects to capsaicin before denervations, presumably due to stimulation of slowly adapting pulmonary stretch receptors. Left atrial injections of veratrine caused hypertension, bradycardia and hyperpnoea, together with an increase in nasal vascular resistance and little change in nasal airways resistance. Thus cardiac receptors seem to increase nasal vascular resistance. Injections of capsaicin and veratrine into the nasal circulation decreased nasal vascular resistance, with a stimulation of breathing and changes in blood pressure. Denervations indicated that these were a combination of local and reflex actions.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3751en_US
dc.relation.ispartofJournal of Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Pressure - Drug Effectsen_US
dc.subject.meshCapsaicin - Pharmacologyen_US
dc.subject.meshDenervationen_US
dc.subject.meshDogsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Rate - Drug Effectsen_US
dc.subject.meshLung - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNose - Blood Supply - Physiologyen_US
dc.subject.meshPulmonary Ventilation - Drug Effectsen_US
dc.subject.meshReflex - Physiologyen_US
dc.subject.meshRespiration - Drug Effectsen_US
dc.subject.meshVagus Nerve - Physiologyen_US
dc.subject.meshVascular Resistance - Drug Effectsen_US
dc.subject.meshVeratrine - Pharmacologyen_US
dc.titleLung reflexes and nasal vascular resistance in the anaesthetized dogen_US
dc.typeArticleen_US
dc.identifier.emailLung, MA:makylung@hkucc.hku.hken_US
dc.identifier.authorityLung, MA=rp00319en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3681716-
dc.identifier.scopuseid_2-s2.0-0023159097en_US
dc.identifier.volumeVol. 386en_US
dc.identifier.spage465en_US
dc.identifier.epage474en_US
dc.identifier.isiWOS:A1987H137900028-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLung, MA=7006411781en_US
dc.identifier.scopusauthoridWiddicombe, JG=7102473701en_US

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