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Article: Sex differences in the serum concentrations of testosterone in mice and hamsters during their critical periods of neural sexual differentiation

TitleSex differences in the serum concentrations of testosterone in mice and hamsters during their critical periods of neural sexual differentiation
Authors
Issue Date1984
PublisherSociety for Endocrinology. The Journal's web site is located at http://joe.endocrinology-journals.org
Citation
Journal Of Endocrinology, 1984, v. 100 n. 1, p. 7-11 How to Cite?
AbstractMale and female mice and hamsters were decapitated 1-5 days after birth and serum concentrations of testosterone determined by radioimmunoassay. in the two species studied, serum levels of testosterone in male pups were significantly (p < 0.05) higher than those obtained in female neonates. this lends support to the hypothesis that circulating levels of testosterone play an important role in the process of neural sexual differentiation in rodents. Moreover, the sex differences in serum concentrations of testosterone in neonatal rodents together with the detectable levels of testosterone in female neonates may suggest that androgenization is a dose-dependent phenomenon. Aledternatively, they may indicate that a minimum concentration of the steroid must be present for androgenization to occur during the critical period of neural sexual differentiation and that this 'threshold' is exceeded in male but not in female rodents.
Persistent Identifierhttp://hdl.handle.net/10722/171489
ISSN
2015 Impact Factor: 4.498
2015 SCImago Journal Rankings: 1.910
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPang, SFen_US
dc.contributor.authorTang, Fen_US
dc.date.accessioned2012-10-30T06:15:24Z-
dc.date.available2012-10-30T06:15:24Z-
dc.date.issued1984en_US
dc.identifier.citationJournal Of Endocrinology, 1984, v. 100 n. 1, p. 7-11en_US
dc.identifier.issn0022-0795en_US
dc.identifier.urihttp://hdl.handle.net/10722/171489-
dc.description.abstractMale and female mice and hamsters were decapitated 1-5 days after birth and serum concentrations of testosterone determined by radioimmunoassay. in the two species studied, serum levels of testosterone in male pups were significantly (p < 0.05) higher than those obtained in female neonates. this lends support to the hypothesis that circulating levels of testosterone play an important role in the process of neural sexual differentiation in rodents. Moreover, the sex differences in serum concentrations of testosterone in neonatal rodents together with the detectable levels of testosterone in female neonates may suggest that androgenization is a dose-dependent phenomenon. Aledternatively, they may indicate that a minimum concentration of the steroid must be present for androgenization to occur during the critical period of neural sexual differentiation and that this 'threshold' is exceeded in male but not in female rodents.en_US
dc.languageengen_US
dc.publisherSociety for Endocrinology. The Journal's web site is located at http://joe.endocrinology-journals.orgen_US
dc.relation.ispartofJournal of Endocrinologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newborn - Blood - Growth & Developmenten_US
dc.subject.meshCricetinae - Blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMesocricetus - Blood - Growth & Developmenten_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Icr - Blood - Growth & Developmenten_US
dc.subject.meshNervous System - Growth & Developmenten_US
dc.subject.meshSex Characteristicsen_US
dc.subject.meshSex Differentiationen_US
dc.subject.meshTestosterone - Blooden_US
dc.titleSex differences in the serum concentrations of testosterone in mice and hamsters during their critical periods of neural sexual differentiationen_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1677/joe.0.1000007-
dc.identifier.pmid6690645-
dc.identifier.scopuseid_2-s2.0-0021320425en_US
dc.identifier.volume100en_US
dc.identifier.issue1en_US
dc.identifier.spage7en_US
dc.identifier.epage11en_US
dc.identifier.isiWOS:A1984RY96700002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridPang, SF=7402528719en_US
dc.identifier.scopusauthoridTang, F=7201979770en_US

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