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Article: Negative correlation of age and the levels of pineal melatonin, pineal N-acetylserotonin, and serum melatonin in male rats.

TitleNegative correlation of age and the levels of pineal melatonin, pineal N-acetylserotonin, and serum melatonin in male rats.
Authors
Issue Date1984
Citation
Journal Of Experimental Zoology, 1984, v. 229 n. 1, p. 41-47 How to Cite?
AbstractPineal concentrations of N-acetylserotonin and melatonin and serum levels of melatonin were studied in 3-wk-old (prepubertal), 8-wk-old (adult), and 17-mo-old (senile) male rats. They were adapted to a photoperiod of 12 h light/12 h darkness for a minimum of 1 wk and killed at mid-light and mid-dark. Melatonin and N-acetylserotonin were determined by radioimmunoassay. The concentrations of pineal N-acetylserotonin and melatonin were high in the dark period and low in the light period. Statistical analysis indicated that pineal N-acetylserotonin and melatonin levels per 100 gm body weight declined with age. Similarly, serum melatonin demonstrated diurnal changes in all the age groups studied. In addition, there was a significant reduction in the levels of serum melatonin with age. The parallel patterns of decrease in pineal and serum melatonin levels with age suggest a decline in pineal secretion of melatonin in the older animals.
Persistent Identifierhttp://hdl.handle.net/10722/171487
ISSN
2003 Impact Factor: -999.999
2005 SCImago Journal Rankings: 0.856
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPang, SFen_US
dc.contributor.authorTang, Fen_US
dc.contributor.authorTang, PLen_US
dc.date.accessioned2012-10-30T06:15:24Z-
dc.date.available2012-10-30T06:15:24Z-
dc.date.issued1984en_US
dc.identifier.citationJournal Of Experimental Zoology, 1984, v. 229 n. 1, p. 41-47en_US
dc.identifier.issn0022-104Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/171487-
dc.description.abstractPineal concentrations of N-acetylserotonin and melatonin and serum levels of melatonin were studied in 3-wk-old (prepubertal), 8-wk-old (adult), and 17-mo-old (senile) male rats. They were adapted to a photoperiod of 12 h light/12 h darkness for a minimum of 1 wk and killed at mid-light and mid-dark. Melatonin and N-acetylserotonin were determined by radioimmunoassay. The concentrations of pineal N-acetylserotonin and melatonin were high in the dark period and low in the light period. Statistical analysis indicated that pineal N-acetylserotonin and melatonin levels per 100 gm body weight declined with age. Similarly, serum melatonin demonstrated diurnal changes in all the age groups studied. In addition, there was a significant reduction in the levels of serum melatonin with age. The parallel patterns of decrease in pineal and serum melatonin levels with age suggest a decline in pineal secretion of melatonin in the older animals.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Experimental Zoologyen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAgingen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCircadian Rhythmen_US
dc.subject.meshMaleen_US
dc.subject.meshMelatonin - Analysis - Blooden_US
dc.subject.meshPineal Gland - Analysis - Physiologyen_US
dc.subject.meshRadioimmunoassayen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strains - Blood - Metabolismen_US
dc.subject.meshSerotonin - Analogs & Derivatives - Analysisen_US
dc.subject.meshSexual Maturationen_US
dc.titleNegative correlation of age and the levels of pineal melatonin, pineal N-acetylserotonin, and serum melatonin in male rats.en_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jez.1402290106-
dc.identifier.pmid6538220-
dc.identifier.scopuseid_2-s2.0-0021314005en_US
dc.identifier.volume229en_US
dc.identifier.issue1en_US
dc.identifier.spage41en_US
dc.identifier.epage47en_US
dc.identifier.isiWOS:A1984SB82800005-
dc.identifier.scopusauthoridPang, SF=7402528719en_US
dc.identifier.scopusauthoridTang, F=7201979770en_US
dc.identifier.scopusauthoridTang, PL=7202102495en_US

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