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Article: Control of nasal vasculature and airflow resistance in the dog

TitleControl of nasal vasculature and airflow resistance in the dog
Authors
Issue Date1984
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3751
Citation
Journal Of Physiology, 1984, v. VOL. 349, p. 535-551 How to Cite?
AbstractNasal vascular and airflow resistances have been measured in dogs, simultaneously on both sides separately. Vascular resistance was measured either by constant flow perfusion of the terminal branch of the maxillary artery (which supplies, via the sphenopalatine artery, the nasal septum, most of the turbinates and the nasal sinuses) or by measuring blood flow through this artery, maintained by the dog's own blood pressure. Airflow resistance was assessed by inserting balloon-tipped endotracheal catheters into the back of each nasal cavity via the nasopharynx, and measuring transnasal pressure at constant airflow through each side of the nose simultaneously. Preliminary experiments indicated that there was 5-10% collateral anastomosis between the two sides. Close-arterial injection of drugs showed different patterns of response. Adrenaline, phenylephrine, chlorpheniramine and low doses of prostaglandin F(2α) increased vascular resistance and lowered airway resistance. Salbutamol, methacholine and histamine lowered vascular resistance and increased airway resistance. Dubutamine decreased airway resistance with a small increase in vascular resistance. Prostaglandins E1, E2 and F(2α) (high dose) decreased both vascular and airway resistances. Substance P, eledoisin-related peptide and vasoactive intestinal polypeptide lowered vascular resistance with little change in airway resistance. The results are interpreted in terms of possible drug actions on precapillary resistance vessels, sinusoids and venules, and arteriovenous anastomoses. It is concluded that nasal airway resistance cannot be correlated with vascular resistance or blood flow, since the latter has a complex and ill-defined relationship with nasal vascular blood volume.
Persistent Identifierhttp://hdl.handle.net/10722/171486
ISSN
2015 Impact Factor: 4.731
2015 SCImago Journal Rankings: 2.670
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLung, MAen_US
dc.contributor.authorPhipps, RJen_US
dc.contributor.authorWang, JCCen_US
dc.contributor.authorWiddicombe, JGen_US
dc.date.accessioned2012-10-30T06:15:24Z-
dc.date.available2012-10-30T06:15:24Z-
dc.date.issued1984en_US
dc.identifier.citationJournal Of Physiology, 1984, v. VOL. 349, p. 535-551en_US
dc.identifier.issn0022-3751en_US
dc.identifier.urihttp://hdl.handle.net/10722/171486-
dc.description.abstractNasal vascular and airflow resistances have been measured in dogs, simultaneously on both sides separately. Vascular resistance was measured either by constant flow perfusion of the terminal branch of the maxillary artery (which supplies, via the sphenopalatine artery, the nasal septum, most of the turbinates and the nasal sinuses) or by measuring blood flow through this artery, maintained by the dog's own blood pressure. Airflow resistance was assessed by inserting balloon-tipped endotracheal catheters into the back of each nasal cavity via the nasopharynx, and measuring transnasal pressure at constant airflow through each side of the nose simultaneously. Preliminary experiments indicated that there was 5-10% collateral anastomosis between the two sides. Close-arterial injection of drugs showed different patterns of response. Adrenaline, phenylephrine, chlorpheniramine and low doses of prostaglandin F(2α) increased vascular resistance and lowered airway resistance. Salbutamol, methacholine and histamine lowered vascular resistance and increased airway resistance. Dubutamine decreased airway resistance with a small increase in vascular resistance. Prostaglandins E1, E2 and F(2α) (high dose) decreased both vascular and airway resistances. Substance P, eledoisin-related peptide and vasoactive intestinal polypeptide lowered vascular resistance with little change in airway resistance. The results are interpreted in terms of possible drug actions on precapillary resistance vessels, sinusoids and venules, and arteriovenous anastomoses. It is concluded that nasal airway resistance cannot be correlated with vascular resistance or blood flow, since the latter has a complex and ill-defined relationship with nasal vascular blood volume.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3751en_US
dc.relation.ispartofJournal of Physiologyen_US
dc.subject.meshAdrenergic Agonists - Pharmacologyen_US
dc.subject.meshAirway Resistance - Drug Effectsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDogsen_US
dc.subject.meshEledoisin - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHistamine Antagonists - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMethacholine Chlorideen_US
dc.subject.meshMethacholine Compounds - Pharmacologyen_US
dc.subject.meshNose - Blood Supply - Drug Effects - Physiologyen_US
dc.subject.meshProstaglandins - Pharmacologyen_US
dc.subject.meshSubstance P - Pharmacologyen_US
dc.subject.meshVascular Resistance - Drug Effectsen_US
dc.subject.meshVasoactive Intestinal Peptide - Pharmacologyen_US
dc.titleControl of nasal vasculature and airflow resistance in the dogen_US
dc.typeArticleen_US
dc.identifier.emailLung, MA:makylung@hkucc.hku.hken_US
dc.identifier.authorityLung, MA=rp00319en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6204040-
dc.identifier.scopuseid_2-s2.0-0021286865en_US
dc.identifier.volumeVOL. 349en_US
dc.identifier.spage535en_US
dc.identifier.epage551en_US
dc.identifier.isiWOS:A1984SN11700035-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLung, MA=7006411781en_US
dc.identifier.scopusauthoridPhipps, RJ=7103320669en_US
dc.identifier.scopusauthoridWang, JCC=7701314571en_US
dc.identifier.scopusauthoridWiddicombe, JG=7102473701en_US

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