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Article: A drug utilisation study of antidepressants in children and adolescents using the General Practice Research Database

TitleA drug utilisation study of antidepressants in children and adolescents using the General Practice Research Database
Authors
Issue Date2004
PublisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/
Citation
Archives Of Disease In Childhood, 2004, v. 89 n. 12, p. 1098-1102 How to Cite?
AbstractAims: To characterise prescribing patterns of antidepressants (ATDs) to children and adolescents aged ≤ 18 years in the UK. Methods: Subjects issued at least one ATD prescription between 1 January 1992 and 31 December 2001 were identified from the UK General Practice Research Database. Prescribing patterns, annual prevalence, morbidity patterns, and time to discontinuation of ATD use were identified. Results: A total of 24 976 subjects received 93 091 prescriptions; 51 868 (55.7%), 38 429 (41.3%), and 2708 (2.9%) prescriptions were for tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and other ATDs respectively. ATD prevalence increased 1.7-fold from 1992 to 2001. TCA prevalence decreased by 30% from 3.6 to 2.5 per 1,000; SSRI prevalence increased 10 times from 0.5 to 4.6 per 1,000. In new ATD users aged ≤ 10 years, the most common diagnosis associated with TCA use was nocturnal enuresis (75.1%); in those aged ≥ 15 years, it was depression (45.8%). Depression was also associated with SSRI use (69.0%). For new users with depression, the median treatment durations for TCAs and SSRIs were 30 and 58 days respectively. TCA users were more likely to terminate treatment than SSRI users (TCAs v fluoxetine: 1.40, 95% CI 1.32 to 1.47; non-fluoxetine SSRIs v fluoxetine: 1.01 95% CI 0.96 to 1.07). Conclusions: SSRIs have gained popularity for the treatment of depression compared with TCAs. TCAs are still used despite their lack of efficacy in prepubertal depression and their moderate effect in adolescents. However, <50% of subjects discontinue treatment after two months, with TCA users stopping earlier than SSRI users.
Persistent Identifierhttp://hdl.handle.net/10722/171454
ISSN
2015 Impact Factor: 3.231
2015 SCImago Journal Rankings: 1.118
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMurray, MLen_US
dc.contributor.authorDe Vries, CSen_US
dc.contributor.authorWong, ICKen_US
dc.date.accessioned2012-10-30T06:14:23Z-
dc.date.available2012-10-30T06:14:23Z-
dc.date.issued2004en_US
dc.identifier.citationArchives Of Disease In Childhood, 2004, v. 89 n. 12, p. 1098-1102en_US
dc.identifier.issn0003-9888en_US
dc.identifier.urihttp://hdl.handle.net/10722/171454-
dc.description.abstractAims: To characterise prescribing patterns of antidepressants (ATDs) to children and adolescents aged ≤ 18 years in the UK. Methods: Subjects issued at least one ATD prescription between 1 January 1992 and 31 December 2001 were identified from the UK General Practice Research Database. Prescribing patterns, annual prevalence, morbidity patterns, and time to discontinuation of ATD use were identified. Results: A total of 24 976 subjects received 93 091 prescriptions; 51 868 (55.7%), 38 429 (41.3%), and 2708 (2.9%) prescriptions were for tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and other ATDs respectively. ATD prevalence increased 1.7-fold from 1992 to 2001. TCA prevalence decreased by 30% from 3.6 to 2.5 per 1,000; SSRI prevalence increased 10 times from 0.5 to 4.6 per 1,000. In new ATD users aged ≤ 10 years, the most common diagnosis associated with TCA use was nocturnal enuresis (75.1%); in those aged ≥ 15 years, it was depression (45.8%). Depression was also associated with SSRI use (69.0%). For new users with depression, the median treatment durations for TCAs and SSRIs were 30 and 58 days respectively. TCA users were more likely to terminate treatment than SSRI users (TCAs v fluoxetine: 1.40, 95% CI 1.32 to 1.47; non-fluoxetine SSRIs v fluoxetine: 1.01 95% CI 0.96 to 1.07). Conclusions: SSRIs have gained popularity for the treatment of depression compared with TCAs. TCAs are still used despite their lack of efficacy in prepubertal depression and their moderate effect in adolescents. However, <50% of subjects discontinue treatment after two months, with TCA users stopping earlier than SSRI users.en_US
dc.languageengen_US
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/en_US
dc.relation.ispartofArchives of Disease in Childhooden_US
dc.subject.meshAdolescenten_US
dc.subject.meshAntidepressive Agents - Therapeutic Useen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDepressive Disorder - Drug Therapyen_US
dc.subject.meshDrug Prescriptions - Statistics & Numerical Dataen_US
dc.subject.meshDrug Utilization - Statistics & Numerical Dataen_US
dc.subject.meshFamily Practice - Statistics & Numerical Dataen_US
dc.subject.meshFemaleen_US
dc.subject.meshGreat Britainen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshPhysician's Practice Patterns - Statistics & Numerical Dataen_US
dc.subject.meshSurvival Analysisen_US
dc.titleA drug utilisation study of antidepressants in children and adolescents using the General Practice Research Databaseen_US
dc.typeArticleen_US
dc.identifier.emailWong, ICK:wongick@hku.hken_US
dc.identifier.authorityWong, ICK=rp01480en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1136/adc.2004.064956en_US
dc.identifier.pmid15557040-
dc.identifier.scopuseid_2-s2.0-9644252829en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-9644252829&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume89en_US
dc.identifier.issue12en_US
dc.identifier.spage1098en_US
dc.identifier.epage1102en_US
dc.identifier.isiWOS:000225250600007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridMurray, ML=7403583537en_US
dc.identifier.scopusauthoridDe Vries, CS=7005874262en_US
dc.identifier.scopusauthoridWong, ICK=7102513915en_US
dc.identifier.citeulike3056587-

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