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Article: Production methods for nanodrug particles using the bottom-up approach

TitleProduction methods for nanodrug particles using the bottom-up approach
Authors
Issue Date2011
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/addr
Citation
Advanced Drug Delivery Reviews, 2011, v. 63 n. 6, p. 406-416 How to Cite?
AbstractThis review focuses on bottom-up processes such as precipitation (or crystallisation) and single droplet evaporation to produce nanoparticles containing largely pure therapeutics for pharmaceutical applications. Suitable precipitation techniques involve the use of high-gravity, confined impinging liquid jet mixing, multi-inlet vortex mixing, supercritical fluids, and ultrasonic waves. Droplet evaporation methods are spray-based, including nanospray drying, aerosol flow reactor method, spraying of low-boiling point solvent under ambient conditions and electrospraying of low-electrical conducting solutions. A key to the success of yielding stable nanoparticles in these various techniques is to control the particle growth kinetics through evaporation rate of the droplets or mixing rate during precipitation. © 2011 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/171423
ISSN
2015 Impact Factor: 15.606
2015 SCImago Journal Rankings: 5.200
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, HKen_US
dc.contributor.authorKwok, PCLen_US
dc.date.accessioned2012-10-30T06:14:05Z-
dc.date.available2012-10-30T06:14:05Z-
dc.date.issued2011en_US
dc.identifier.citationAdvanced Drug Delivery Reviews, 2011, v. 63 n. 6, p. 406-416en_US
dc.identifier.issn0169-409Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/171423-
dc.description.abstractThis review focuses on bottom-up processes such as precipitation (or crystallisation) and single droplet evaporation to produce nanoparticles containing largely pure therapeutics for pharmaceutical applications. Suitable precipitation techniques involve the use of high-gravity, confined impinging liquid jet mixing, multi-inlet vortex mixing, supercritical fluids, and ultrasonic waves. Droplet evaporation methods are spray-based, including nanospray drying, aerosol flow reactor method, spraying of low-boiling point solvent under ambient conditions and electrospraying of low-electrical conducting solutions. A key to the success of yielding stable nanoparticles in these various techniques is to control the particle growth kinetics through evaporation rate of the droplets or mixing rate during precipitation. © 2011 Elsevier B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/addren_US
dc.relation.ispartofAdvanced Drug Delivery Reviewsen_US
dc.subject.meshCrystallization - Methodsen_US
dc.subject.meshDrug Delivery Systems - Methodsen_US
dc.subject.meshNanoparticles - Administration & Dosage - Chemistryen_US
dc.subject.meshNanotechnology - Methodsen_US
dc.titleProduction methods for nanodrug particles using the bottom-up approachen_US
dc.typeArticleen_US
dc.identifier.emailKwok, PCL:pclkwok@hku.hken_US
dc.identifier.authorityKwok, PCL=rp01540en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.addr.2011.03.011en_US
dc.identifier.pmid21457742-
dc.identifier.scopuseid_2-s2.0-79957768993en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79957768993&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume63en_US
dc.identifier.issue6en_US
dc.identifier.spage406en_US
dc.identifier.epage416en_US
dc.identifier.isiWOS:000292537800002-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridChan, HK=7403402677en_US
dc.identifier.scopusauthoridKwok, PCL=12646007800en_US
dc.identifier.citeulike9125883-

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