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Article: Formation of protein nano-matrix particles with controlled surface architecture for respiratory drug delivery

TitleFormation of protein nano-matrix particles with controlled surface architecture for respiratory drug delivery
Authors
Issue Date2011
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741
Citation
Pharmaceutical Research, 2011, v. 28 n. 4, p. 788-796 How to Cite?
AbstractPurpose: To produce and examine the aerosol performance of protein nano-matrix particles with different surface roughness. Methods: Aqueous lysozyme solutions were poured into isopropanol during high-shear mixing to produce nanoparticles by precipitation. The size of the nanoparticles was varied by adjusting the precipitation conditions. The resultant suspensions were spray-dried to obtain micron-sized aggregates (nano-matrices). Smooth particles were made by spray-drying a lysozyme solution. The aggregate size distribution, surface roughness, and cohesion were evaluated. The aerosol performance was assessed by dispersing 10 mg of powder from a Rotahaler ® at 60 L/min or an Aerolizer® at 100 L/min into a Next Generation Impactor, followed by chemical assay (n∈=∈3). Results: The median volume diameter and span of the nano-matrix particles were 1.0-1.2 μm and 1.5-1.6, respectively, which were comparable to those of the smooth particles. Surface roughness increased with the size of the primary nanoparticles. The nano-matrix particles were significantly less cohesive than the smooth particles. The fine particle fraction increased linearly with increasing surface roughness and decreasing cohesion. Conclusions: Nano-matrix particles with controlled surface architecture were successfully produced by spray-drying nanosuspensions. Aerosol performance was enhanced with increasing surface roughness due to the reduction in cohesion forces. © 2010 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/171420
ISSN
2015 Impact Factor: 3.26
2015 SCImago Journal Rankings: 1.189
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwok, PCLen_US
dc.contributor.authorTunsirikongkon, Aen_US
dc.contributor.authorGlover, Wen_US
dc.contributor.authorChan, HKen_US
dc.date.accessioned2012-10-30T06:14:04Z-
dc.date.available2012-10-30T06:14:04Z-
dc.date.issued2011en_US
dc.identifier.citationPharmaceutical Research, 2011, v. 28 n. 4, p. 788-796en_US
dc.identifier.issn0724-8741en_US
dc.identifier.urihttp://hdl.handle.net/10722/171420-
dc.description.abstractPurpose: To produce and examine the aerosol performance of protein nano-matrix particles with different surface roughness. Methods: Aqueous lysozyme solutions were poured into isopropanol during high-shear mixing to produce nanoparticles by precipitation. The size of the nanoparticles was varied by adjusting the precipitation conditions. The resultant suspensions were spray-dried to obtain micron-sized aggregates (nano-matrices). Smooth particles were made by spray-drying a lysozyme solution. The aggregate size distribution, surface roughness, and cohesion were evaluated. The aerosol performance was assessed by dispersing 10 mg of powder from a Rotahaler ® at 60 L/min or an Aerolizer® at 100 L/min into a Next Generation Impactor, followed by chemical assay (n∈=∈3). Results: The median volume diameter and span of the nano-matrix particles were 1.0-1.2 μm and 1.5-1.6, respectively, which were comparable to those of the smooth particles. Surface roughness increased with the size of the primary nanoparticles. The nano-matrix particles were significantly less cohesive than the smooth particles. The fine particle fraction increased linearly with increasing surface roughness and decreasing cohesion. Conclusions: Nano-matrix particles with controlled surface architecture were successfully produced by spray-drying nanosuspensions. Aerosol performance was enhanced with increasing surface roughness due to the reduction in cohesion forces. © 2010 Springer Science+Business Media, LLC.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741en_US
dc.relation.ispartofPharmaceutical Researchen_US
dc.subject.mesh2-Propanol - Chemistryen_US
dc.subject.meshAdministration, Inhalationen_US
dc.subject.meshAerosolsen_US
dc.subject.meshChemistry, Pharmaceuticalen_US
dc.subject.meshDrug Carriers - Chemistryen_US
dc.subject.meshDry Powder Inhalersen_US
dc.subject.meshLighten_US
dc.subject.meshMicroscopy, Atomic Forceen_US
dc.subject.meshMicroscopy, Electron, Scanningen_US
dc.subject.meshMuramidase - Chemistryen_US
dc.subject.meshNanoparticles - Chemistryen_US
dc.subject.meshParticle Sizeen_US
dc.subject.meshPharmaceutical Preparations - Administration & Dosageen_US
dc.subject.meshScattering, Radiationen_US
dc.subject.meshSurface Propertiesen_US
dc.titleFormation of protein nano-matrix particles with controlled surface architecture for respiratory drug deliveryen_US
dc.typeArticleen_US
dc.identifier.emailKwok, PCL:pclkwok@hku.hken_US
dc.identifier.authorityKwok, PCL=rp01540en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s11095-010-0332-2en_US
dc.identifier.pmid21136142-
dc.identifier.scopuseid_2-s2.0-79955603054en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955603054&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume28en_US
dc.identifier.issue4en_US
dc.identifier.spage788en_US
dc.identifier.epage796en_US
dc.identifier.eissn1573-904X-
dc.identifier.isiWOS:000288805300011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKwok, PCL=12646007800en_US
dc.identifier.scopusauthoridTunsirikongkon, A=36651806000en_US
dc.identifier.scopusauthoridGlover, W=7005874010en_US
dc.identifier.scopusauthoridChan, HK=7403402677en_US
dc.identifier.citeulike8421169-

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