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Article: The prescribing of analgesics and non-steroidal anti-inflammatory drugs in paediatric primary care in the UK, Italy and the Netherlands

TitleThe prescribing of analgesics and non-steroidal anti-inflammatory drugs in paediatric primary care in the UK, Italy and the Netherlands
Authors
Issue Date2010
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/issn/10436618
Citation
Pharmacological Research, 2010, v. 62 n. 3, p. 243-248 How to Cite?
AbstractNon-steroidal anti-inflammatory drugs (NSAIDs) and opioids are commonly prescribed drugs which are frequently used for the treatment of various painful conditions. However, particularly for the paediatric population, there is a lack of information on effectiveness, safety and appropriate formulation resulting in off-label use and undertreatment. The aim of this study was to investigate the prescribing patterns of non-steroid anti-inflammatory drugs and opioids in children and adolescents in three European countries. A retrospective cohort study was conducted using the same protocol in three primary care databases: Pedianet (Italy), IPCI (Netherlands) and IMS Disease Analyzer (UK). User prevalence rates were calculated for opioids (N02A) and non-steroidal anti-inflammatory drugs (NSAIDs) (M01A) based on ATC therapeutic and chemical levels and stratified by country, age and gender. The prescribing prevalence for NSAIDs was lower in the Netherlands compared to Italy and the UK. Ibuprofen was the most frequently prescribed drug in this group in Italy (20.8 users/1000. PY) and the UK (30.6 users/1000. PY) whereas diclofenac was dominant in the Netherlands (1.7 users/1000. PY). Among opioids, codeine and codeine combinations were most commonly prescribed; only little use was seen for other drugs. There is a great variety of different NSAIDs and opioids prescribed to children in Europe in primary care. This is due to a varying availability of drugs in different countries but also because of differing prescribing attitudes, reimbursement scheme and a lack of data on the effectiveness of individual drugs. Further research into the rationale for prescribing these drugs to children is clearly needed. © 2010 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/171403
ISSN
2015 Impact Factor: 4.816
2015 SCImago Journal Rankings: 2.108
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNeubert, Aen_US
dc.contributor.authorVerhamme, Ken_US
dc.contributor.authorMurray, MLen_US
dc.contributor.authorPicelli, Gen_US
dc.contributor.authorHsia, Yen_US
dc.contributor.authorSen, FEen_US
dc.contributor.authorGiaquinto, Cen_US
dc.contributor.authorCeci, Aen_US
dc.contributor.authorSturkenboom, Men_US
dc.contributor.authorWong, ICKen_US
dc.date.accessioned2012-10-30T06:13:56Z-
dc.date.available2012-10-30T06:13:56Z-
dc.date.issued2010en_US
dc.identifier.citationPharmacological Research, 2010, v. 62 n. 3, p. 243-248en_US
dc.identifier.issn1043-6618en_US
dc.identifier.urihttp://hdl.handle.net/10722/171403-
dc.description.abstractNon-steroidal anti-inflammatory drugs (NSAIDs) and opioids are commonly prescribed drugs which are frequently used for the treatment of various painful conditions. However, particularly for the paediatric population, there is a lack of information on effectiveness, safety and appropriate formulation resulting in off-label use and undertreatment. The aim of this study was to investigate the prescribing patterns of non-steroid anti-inflammatory drugs and opioids in children and adolescents in three European countries. A retrospective cohort study was conducted using the same protocol in three primary care databases: Pedianet (Italy), IPCI (Netherlands) and IMS Disease Analyzer (UK). User prevalence rates were calculated for opioids (N02A) and non-steroidal anti-inflammatory drugs (NSAIDs) (M01A) based on ATC therapeutic and chemical levels and stratified by country, age and gender. The prescribing prevalence for NSAIDs was lower in the Netherlands compared to Italy and the UK. Ibuprofen was the most frequently prescribed drug in this group in Italy (20.8 users/1000. PY) and the UK (30.6 users/1000. PY) whereas diclofenac was dominant in the Netherlands (1.7 users/1000. PY). Among opioids, codeine and codeine combinations were most commonly prescribed; only little use was seen for other drugs. There is a great variety of different NSAIDs and opioids prescribed to children in Europe in primary care. This is due to a varying availability of drugs in different countries but also because of differing prescribing attitudes, reimbursement scheme and a lack of data on the effectiveness of individual drugs. Further research into the rationale for prescribing these drugs to children is clearly needed. © 2010 Elsevier Ltd.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/issn/10436618en_US
dc.relation.ispartofPharmacological Researchen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAnalgesics - Therapeutic Useen_US
dc.subject.meshAnalgesics, Opioid - Therapeutic Useen_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal - Therapeutic Useen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshDrug Utilizationen_US
dc.subject.meshGreat Britainen_US
dc.subject.meshHumansen_US
dc.subject.meshIbuprofen - Therapeutic Useen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshItalyen_US
dc.subject.meshNetherlandsen_US
dc.subject.meshPrimary Health Careen_US
dc.subject.meshRetrospective Studiesen_US
dc.titleThe prescribing of analgesics and non-steroidal anti-inflammatory drugs in paediatric primary care in the UK, Italy and the Netherlandsen_US
dc.typeArticleen_US
dc.identifier.emailWong, ICK:wongick@hku.hken_US
dc.identifier.authorityWong, ICK=rp01480en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.phrs.2010.04.006en_US
dc.identifier.pmid20451614-
dc.identifier.scopuseid_2-s2.0-77954145330en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954145330&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume62en_US
dc.identifier.issue3en_US
dc.identifier.spage243en_US
dc.identifier.epage248en_US
dc.identifier.isiWOS:000280117900006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridNeubert, A=7003774960en_US
dc.identifier.scopusauthoridVerhamme, K=6507849095en_US
dc.identifier.scopusauthoridMurray, ML=7403583537en_US
dc.identifier.scopusauthoridPicelli, G=14033193500en_US
dc.identifier.scopusauthoridHsia, Y=35068032100en_US
dc.identifier.scopusauthoridSen, FE=36070870100en_US
dc.identifier.scopusauthoridGiaquinto, C=7006585659en_US
dc.identifier.scopusauthoridCeci, A=7006836326en_US
dc.identifier.scopusauthoridSturkenboom, M=21743803900en_US
dc.identifier.scopusauthoridWong, ICK=7102513915en_US
dc.identifier.citeulike7150619-

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