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Article: Effects of the aqueous extract of Salvia Miltiorrhiza (Danshen) and its magnesium tanshinoate B-enriched form on blood pressure

TitleEffects of the aqueous extract of Salvia Miltiorrhiza (Danshen) and its magnesium tanshinoate B-enriched form on blood pressure
Authors
Issue Date2010
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567
Citation
Phytotherapy Research, 2010, v. 24 n. 5, p. 769-774 How to Cite?
AbstractDanshen is the dried root and rhizome of the Chinese medicinal plant Salvia miltiorrhiza Bunge (Labiatae), which has been used to treat hypertension and myocardial infarction. One of its water-soluble active components is magnesium tanshinoate B (MTB). The present study examined and compared the cardiovascular effects of the water-soluble extract of danshen (SME) and its MTB-enriched form (containing 70% of MTB (MTB70)). Anaesthetized rats were infused intravenously with saline or phenylephrine to achieve a normal or elevated blood pressure, respectively. Different doses of SME, MTB70 or vehicle were then injected intravenously and their effect on blood pressure was monitored. The results indicate that SME and MTB70 reduce blood pressure dose-dependently. Independently of the initial blood pressure, SME caused a smaller reduction in blood pressure than MTB70. In rats infused with phenylephrine, MTB70 caused greater decreases in blood pressure than in rats infused with saline, while the responses to SME did not differ between the two groups. From these findings, it appears that MTB is one of the major components responsible for the cardiovascular effects of danshen, and that the beneficial cardiovascular effect of the extract is more prominent under conditions of elevated blood pressure. Copyright © 2009 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/171402
ISSN
2015 Impact Factor: 2.694
2015 SCImago Journal Rankings: 0.842
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, SWSen_US
dc.contributor.authorZhu, DYen_US
dc.contributor.authorMan, RYKen_US
dc.date.accessioned2012-10-30T06:13:55Z-
dc.date.available2012-10-30T06:13:55Z-
dc.date.issued2010en_US
dc.identifier.citationPhytotherapy Research, 2010, v. 24 n. 5, p. 769-774en_US
dc.identifier.issn0951-418Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/171402-
dc.description.abstractDanshen is the dried root and rhizome of the Chinese medicinal plant Salvia miltiorrhiza Bunge (Labiatae), which has been used to treat hypertension and myocardial infarction. One of its water-soluble active components is magnesium tanshinoate B (MTB). The present study examined and compared the cardiovascular effects of the water-soluble extract of danshen (SME) and its MTB-enriched form (containing 70% of MTB (MTB70)). Anaesthetized rats were infused intravenously with saline or phenylephrine to achieve a normal or elevated blood pressure, respectively. Different doses of SME, MTB70 or vehicle were then injected intravenously and their effect on blood pressure was monitored. The results indicate that SME and MTB70 reduce blood pressure dose-dependently. Independently of the initial blood pressure, SME caused a smaller reduction in blood pressure than MTB70. In rats infused with phenylephrine, MTB70 caused greater decreases in blood pressure than in rats infused with saline, while the responses to SME did not differ between the two groups. From these findings, it appears that MTB is one of the major components responsible for the cardiovascular effects of danshen, and that the beneficial cardiovascular effect of the extract is more prominent under conditions of elevated blood pressure. Copyright © 2009 John Wiley & Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567en_US
dc.relation.ispartofPhytotherapy Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntihypertensive Agents - Pharmacologyen_US
dc.subject.meshBlood Pressure - Drug Effectsen_US
dc.subject.meshDrugs, Chinese Herbal - Pharmacologyen_US
dc.subject.meshHeart Rate - Drug Effectsen_US
dc.subject.meshMagnesium - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPhenanthrolines - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSalvia Miltiorrhiza - Chemistryen_US
dc.titleEffects of the aqueous extract of Salvia Miltiorrhiza (Danshen) and its magnesium tanshinoate B-enriched form on blood pressureen_US
dc.typeArticleen_US
dc.identifier.emailLeung, SWS:swsleung@hku.hken_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityLeung, SWS=rp00235en_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ptr.3047en_US
dc.identifier.pmid19943333-
dc.identifier.scopuseid_2-s2.0-77952066947en_US
dc.identifier.hkuros172948-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952066947&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume24en_US
dc.identifier.issue5en_US
dc.identifier.spage769en_US
dc.identifier.epage774en_US
dc.identifier.isiWOS:000277961600023-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLeung, SWS=24540419500en_US
dc.identifier.scopusauthoridZhu, DY=7403598969en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US

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