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- Publisher Website: 10.1038/ki.2008.684
- Scopus: eid_2-s2.0-63949086024
- PMID: 19165174
- WOS: WOS:000264747900008
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Article: Activation of A2 adenosine receptors dilates cortical efferent arterioles in mouse
Title | Activation of A2 adenosine receptors dilates cortical efferent arterioles in mouse |
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Authors | |
Keywords | Glomerular arterioles Renal hemodynamics Vascular purin |
Issue Date | 2009 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/ki/index.html |
Citation | Kidney International, 2009, v. 75 n. 8, p. 793-799 How to Cite? |
Abstract | Adenosine can induce vasodilatation and vasoconstriction of the renal afferent arteriole of the mouse. We determined here its direct effect on efferent arterioles of mouse kidneys. Using isolated-perfused cortical efferent arterioles, we measured changes in luminal diameter in response to adenosine. Extraluminal application of adenosine and cyclohexyladenosine had no effect on the luminal diameter. When the vessels were constricted by the thromboxane mimetic U46619, application of adenosine and 5′-N-ethylcarboxamido- adenosine dilated the efferent arterioles in a dose-dependent manner. We also found that the adenosine-induced vasodilatation was inhibited by the A 2 -specific receptor blocker 3,7-dimethyl-1-propargylxanthine. In the presence of this inhibitor, adenosine failed to alter the basal vessel diameter of quiescent efferent arterioles. Using primer-specific polymerase chain reaction we found that the adenosine A1, A2a, A 2b, and A3 receptors were expressed in microdissected mouse efferent arterioles. We conclude that adenosine dilates the efferent arteriole using the A2 receptor subtype at concentrations compatible with activation of the A2b receptor. © 2009 International Society of Nephrology. |
Persistent Identifier | http://hdl.handle.net/10722/171378 |
ISSN | 2023 Impact Factor: 14.8 2023 SCImago Journal Rankings: 3.886 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | AlMashhadi, RH | en_US |
dc.contributor.author | Skøtt, O | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.contributor.author | Hansen, PB | en_US |
dc.date.accessioned | 2012-10-30T06:13:44Z | - |
dc.date.available | 2012-10-30T06:13:44Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Kidney International, 2009, v. 75 n. 8, p. 793-799 | en_US |
dc.identifier.issn | 0085-2538 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171378 | - |
dc.description.abstract | Adenosine can induce vasodilatation and vasoconstriction of the renal afferent arteriole of the mouse. We determined here its direct effect on efferent arterioles of mouse kidneys. Using isolated-perfused cortical efferent arterioles, we measured changes in luminal diameter in response to adenosine. Extraluminal application of adenosine and cyclohexyladenosine had no effect on the luminal diameter. When the vessels were constricted by the thromboxane mimetic U46619, application of adenosine and 5′-N-ethylcarboxamido- adenosine dilated the efferent arterioles in a dose-dependent manner. We also found that the adenosine-induced vasodilatation was inhibited by the A 2 -specific receptor blocker 3,7-dimethyl-1-propargylxanthine. In the presence of this inhibitor, adenosine failed to alter the basal vessel diameter of quiescent efferent arterioles. Using primer-specific polymerase chain reaction we found that the adenosine A1, A2a, A 2b, and A3 receptors were expressed in microdissected mouse efferent arterioles. We conclude that adenosine dilates the efferent arteriole using the A2 receptor subtype at concentrations compatible with activation of the A2b receptor. © 2009 International Society of Nephrology. | en_US |
dc.language | eng | en_US |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/ki/index.html | en_US |
dc.relation.ispartof | Kidney International | en_US |
dc.subject | Glomerular arterioles | - |
dc.subject | Renal hemodynamics | - |
dc.subject | Vascular purin | - |
dc.subject.mesh | Adenosine - Analogs & Derivatives - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Arterioles - Chemistry | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Kidney Cortex - Blood Supply | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Polymerase Chain Reaction | en_US |
dc.subject.mesh | Receptor, Adenosine A1 - Analysis - Genetics | en_US |
dc.subject.mesh | Receptor, Adenosine A2a - Analysis - Genetics | en_US |
dc.subject.mesh | Receptor, Adenosine A2b - Analysis - Genetics | en_US |
dc.subject.mesh | Receptor, Adenosine A3 - Analysis - Genetics | en_US |
dc.subject.mesh | Receptors, Adenosine A2 - Metabolism - Physiology | en_US |
dc.subject.mesh | Vasodilation - Drug Effects | en_US |
dc.title | Activation of A2 adenosine receptors dilates cortical efferent arterioles in mouse | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1038/ki.2008.684 | en_US |
dc.identifier.pmid | 19165174 | - |
dc.identifier.scopus | eid_2-s2.0-63949086024 | en_US |
dc.identifier.hkuros | 167580 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-63949086024&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 75 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.spage | 793 | en_US |
dc.identifier.epage | 799 | en_US |
dc.identifier.isi | WOS:000264747900008 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | AlMashhadi, RH=26636835500 | en_US |
dc.identifier.scopusauthorid | Skøtt, O=7005724990 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.scopusauthorid | Hansen, PB=35472646600 | en_US |
dc.identifier.issnl | 0085-2538 | - |