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Article: Activation of A2 adenosine receptors dilates cortical efferent arterioles in mouse

TitleActivation of A2 adenosine receptors dilates cortical efferent arterioles in mouse
Authors
Issue Date2009
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ki/index.html
Citation
Kidney International, 2009, v. 75 n. 8, p. 793-799 How to Cite?
AbstractAdenosine can induce vasodilatation and vasoconstriction of the renal afferent arteriole of the mouse. We determined here its direct effect on efferent arterioles of mouse kidneys. Using isolated-perfused cortical efferent arterioles, we measured changes in luminal diameter in response to adenosine. Extraluminal application of adenosine and cyclohexyladenosine had no effect on the luminal diameter. When the vessels were constricted by the thromboxane mimetic U46619, application of adenosine and 5′-N-ethylcarboxamido- adenosine dilated the efferent arterioles in a dose-dependent manner. We also found that the adenosine-induced vasodilatation was inhibited by the A 2 -specific receptor blocker 3,7-dimethyl-1-propargylxanthine. In the presence of this inhibitor, adenosine failed to alter the basal vessel diameter of quiescent efferent arterioles. Using primer-specific polymerase chain reaction we found that the adenosine A1, A2a, A 2b, and A3 receptors were expressed in microdissected mouse efferent arterioles. We conclude that adenosine dilates the efferent arteriole using the A2 receptor subtype at concentrations compatible with activation of the A2b receptor. © 2009 International Society of Nephrology.
Persistent Identifierhttp://hdl.handle.net/10722/171378
ISSN
2015 Impact Factor: 7.683
2015 SCImago Journal Rankings: 3.181
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAlMashhadi, RHen_US
dc.contributor.authorSkøtt, Oen_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorHansen, PBen_US
dc.date.accessioned2012-10-30T06:13:44Z-
dc.date.available2012-10-30T06:13:44Z-
dc.date.issued2009en_US
dc.identifier.citationKidney International, 2009, v. 75 n. 8, p. 793-799en_US
dc.identifier.issn0085-2538en_US
dc.identifier.urihttp://hdl.handle.net/10722/171378-
dc.description.abstractAdenosine can induce vasodilatation and vasoconstriction of the renal afferent arteriole of the mouse. We determined here its direct effect on efferent arterioles of mouse kidneys. Using isolated-perfused cortical efferent arterioles, we measured changes in luminal diameter in response to adenosine. Extraluminal application of adenosine and cyclohexyladenosine had no effect on the luminal diameter. When the vessels were constricted by the thromboxane mimetic U46619, application of adenosine and 5′-N-ethylcarboxamido- adenosine dilated the efferent arterioles in a dose-dependent manner. We also found that the adenosine-induced vasodilatation was inhibited by the A 2 -specific receptor blocker 3,7-dimethyl-1-propargylxanthine. In the presence of this inhibitor, adenosine failed to alter the basal vessel diameter of quiescent efferent arterioles. Using primer-specific polymerase chain reaction we found that the adenosine A1, A2a, A 2b, and A3 receptors were expressed in microdissected mouse efferent arterioles. We conclude that adenosine dilates the efferent arteriole using the A2 receptor subtype at concentrations compatible with activation of the A2b receptor. © 2009 International Society of Nephrology.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ki/index.htmlen_US
dc.relation.ispartofKidney Internationalen_US
dc.subject.meshAdenosine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArterioles - Chemistryen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshKidney Cortex - Blood Supplyen_US
dc.subject.meshMiceen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshReceptor, Adenosine A1 - Analysis - Geneticsen_US
dc.subject.meshReceptor, Adenosine A2a - Analysis - Geneticsen_US
dc.subject.meshReceptor, Adenosine A2b - Analysis - Geneticsen_US
dc.subject.meshReceptor, Adenosine A3 - Analysis - Geneticsen_US
dc.subject.meshReceptors, Adenosine A2 - Metabolism - Physiologyen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.titleActivation of A2 adenosine receptors dilates cortical efferent arterioles in mouseen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/ki.2008.684en_US
dc.identifier.pmid19165174-
dc.identifier.scopuseid_2-s2.0-63949086024en_US
dc.identifier.hkuros167580-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-63949086024&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume75en_US
dc.identifier.issue8en_US
dc.identifier.spage793en_US
dc.identifier.epage799en_US
dc.identifier.isiWOS:000264747900008-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridAlMashhadi, RH=26636835500en_US
dc.identifier.scopusauthoridSkøtt, O=7005724990en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridHansen, PB=35472646600en_US

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