File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effect of naturally occurring catecholamines on adrenergic neuroeffector interaction in the canine saphenous vein

TitleEffect of naturally occurring catecholamines on adrenergic neuroeffector interaction in the canine saphenous vein
Authors
Issue Date1979
Citation
Advances In The Biosciences, 1979, v. 18 C, p. 111-116 How to Cite?
AbstractExperiments were performed to compare the effects of dopamine, epinine and norepinephrine on peripheral adrenergic neurotransmission. Helical strips of dog's saphenous veins were incubated in solutions containing 3H-norepinephrine and mounted for superfusion and determination of 3H-norepinephrine and metabolites in the superfusate. In control strips, but not in veins treated with cocaine, the catecholamines increased the efflux of 3H-norepinephrine and its deaminated metabolites, indicating intraneuronal displacement of transmitter. Equipotent doses (ED50 for activation of alpha receptors on the smooth muscle cells) of norepinephrine, but not of epinine and dopamine, reduced slightly the release of 3H-norepinephrine during electrical stimulation. In strips treated with cocaine, norepinephrine reduced the 3H-norepinephrine release evoked by nerve stimulation by 61.4, epinine by 44.1 and dopamine by 28.5%. The inhibitory effect of the three catecholamines was abolished by phentolamine. These experiments suggest that (1) prejunctional alpha receptors have a different affinity than postjunctional alpha receptors; (2) in the dog's saphenous vein alpha-receptor mediated feedback inhibition of norepinephrine release can be demonstrated best when neuronal uptake is inhibited. © 1979.
Persistent Identifierhttp://hdl.handle.net/10722/171371
ISSN

 

DC FieldValueLanguage
dc.contributor.authorDalemans, Pen_US
dc.contributor.authorJanssens, WJen_US
dc.contributor.authorVerbeuren, TJen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:13:39Z-
dc.date.available2012-10-30T06:13:39Z-
dc.date.issued1979en_US
dc.identifier.citationAdvances In The Biosciences, 1979, v. 18 C, p. 111-116en_US
dc.identifier.issn0065-3446en_US
dc.identifier.urihttp://hdl.handle.net/10722/171371-
dc.description.abstractExperiments were performed to compare the effects of dopamine, epinine and norepinephrine on peripheral adrenergic neurotransmission. Helical strips of dog's saphenous veins were incubated in solutions containing 3H-norepinephrine and mounted for superfusion and determination of 3H-norepinephrine and metabolites in the superfusate. In control strips, but not in veins treated with cocaine, the catecholamines increased the efflux of 3H-norepinephrine and its deaminated metabolites, indicating intraneuronal displacement of transmitter. Equipotent doses (ED50 for activation of alpha receptors on the smooth muscle cells) of norepinephrine, but not of epinine and dopamine, reduced slightly the release of 3H-norepinephrine during electrical stimulation. In strips treated with cocaine, norepinephrine reduced the 3H-norepinephrine release evoked by nerve stimulation by 61.4, epinine by 44.1 and dopamine by 28.5%. The inhibitory effect of the three catecholamines was abolished by phentolamine. These experiments suggest that (1) prejunctional alpha receptors have a different affinity than postjunctional alpha receptors; (2) in the dog's saphenous vein alpha-receptor mediated feedback inhibition of norepinephrine release can be demonstrated best when neuronal uptake is inhibited. © 1979.en_US
dc.languageengen_US
dc.relation.ispartofAdvances in the Biosciencesen_US
dc.titleEffect of naturally occurring catecholamines on adrenergic neuroeffector interaction in the canine saphenous veinen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-49249151005en_US
dc.identifier.volume18en_US
dc.identifier.issueCen_US
dc.identifier.spage111en_US
dc.identifier.epage116en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridDalemans, P=6506939428en_US
dc.identifier.scopusauthoridJanssens, WJ=7006876881en_US
dc.identifier.scopusauthoridVerbeuren, TJ=7007006534en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats