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Article: Effect of intracoronary L-NAME infusion on endothelial dysfunction and intimal hyperplasia after heart transplantation

TitleEffect of intracoronary L-NAME infusion on endothelial dysfunction and intimal hyperplasia after heart transplantation
Authors
Issue Date1998
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
Faseb Journal, 1998, v. 12 n. 5, p. A978 How to Cite?
AbstractThe present study was designed to examine the effect of nitric oxide synthase inhibition on coronary endothelial dysfunction and the development of accelerated atherosclerosis after heart transplantation. A porcine model was used to study the effect of inhibition of endothelial nitric oxide synthase by intracoronary L-Nitro Arginine Methyl Ester (L-NAME; 1 mg/kg/day) infusion by an osmotic pump on these two end-points. The endothelium-dependent relaxations of allografted epicardial coronary arteries, allografted arteries infused with L-NAME, allografted arteries mounted with the pump and vehicle and native coronary arteries were compared 30 days after graft implantation using standard organ chamber experiments. Intimai thickening was measured by light microscopy examination using a semiquantitative scale (0 to 4+ grading). There was a significant decrease of relaxations to serotonin in allografted arteries infused directly with L-NAME compared with allografted arteries from swines receiving the drug. There was a significant increase in the prevalence and severity of intimai thickening in allografted coronary arteries infused with L-NAME compared to allografts without infusion (prevalence: 100%, grade 3-4+ lesions 37.5%, and prevalence: 46.6%, grade 3-4 lesions: 0% respectively). Inhibition of the nitric oxide pathway accelerates the intimai thickening process leading to graft coronary vasculopathy.
Persistent Identifierhttp://hdl.handle.net/10722/171348
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorPerrault, LPen_US
dc.contributor.authorBidouard, JPen_US
dc.contributor.authorVilleneuve, Nen_US
dc.contributor.authorVilaine, JPen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:13:31Z-
dc.date.available2012-10-30T06:13:31Z-
dc.date.issued1998en_US
dc.identifier.citationFaseb Journal, 1998, v. 12 n. 5, p. A978en_US
dc.identifier.issn0892-6638en_US
dc.identifier.urihttp://hdl.handle.net/10722/171348-
dc.description.abstractThe present study was designed to examine the effect of nitric oxide synthase inhibition on coronary endothelial dysfunction and the development of accelerated atherosclerosis after heart transplantation. A porcine model was used to study the effect of inhibition of endothelial nitric oxide synthase by intracoronary L-Nitro Arginine Methyl Ester (L-NAME; 1 mg/kg/day) infusion by an osmotic pump on these two end-points. The endothelium-dependent relaxations of allografted epicardial coronary arteries, allografted arteries infused with L-NAME, allografted arteries mounted with the pump and vehicle and native coronary arteries were compared 30 days after graft implantation using standard organ chamber experiments. Intimai thickening was measured by light microscopy examination using a semiquantitative scale (0 to 4+ grading). There was a significant decrease of relaxations to serotonin in allografted arteries infused directly with L-NAME compared with allografted arteries from swines receiving the drug. There was a significant increase in the prevalence and severity of intimai thickening in allografted coronary arteries infused with L-NAME compared to allografts without infusion (prevalence: 100%, grade 3-4+ lesions 37.5%, and prevalence: 46.6%, grade 3-4 lesions: 0% respectively). Inhibition of the nitric oxide pathway accelerates the intimai thickening process leading to graft coronary vasculopathy.en_US
dc.languageengen_US
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/en_US
dc.relation.ispartofFASEB Journalen_US
dc.titleEffect of intracoronary L-NAME infusion on endothelial dysfunction and intimal hyperplasia after heart transplantationen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33749332831en_US
dc.identifier.volume12en_US
dc.identifier.issue5en_US
dc.identifier.spageA978en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridPerrault, LP=7004370552en_US
dc.identifier.scopusauthoridBidouard, JP=6601955808en_US
dc.identifier.scopusauthoridVilleneuve, N=7003458215en_US
dc.identifier.scopusauthoridVilaine, JP=7004617134en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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