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Article: Membrane hyperpolarization and relaxation of canine blood vessels to vasoactive intestinal polypeptide

TitleMembrane hyperpolarization and relaxation of canine blood vessels to vasoactive intestinal polypeptide
Authors
Issue Date1996
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
Faseb Journal, 1996, v. 10 n. 3, p. A69 How to Cite?
AbstractThe present study was designed to determine the influence of the vascular endothelium on membrane hyperpolarization induced by vasoactive intestinal polypeptide (VIP) in smooth muscle cells of canine isolated blood vessels, and the potential contribution that these electrophysiological changes may make to the relaxant effects of VIP. Membrane potential was measured in isolated canine coronary arteries and saphenous veins, using glass microelectrodes, and isometric force was recorded in a conventional organ chamber apparatus. All experiments were performed in the presence of indomethacin and nitro-L-arginine. VIP (10-9 M - 10-7 M) induced concentration-dependent and endothelium-independent hyperpolarization of the saphenous vein. This response was abolished by glibenclamide (10-6 M). VIP did not induce hyperpolarization of the coronary arterial preparations either in the presence or absence of the endothelium. VIP caused concentration-dependent and endothelium-independent relaxations of rings of both canine arterial and venous preparations. The relaxation of the saphenous vein to VIP was not influenced by glibenclamide (10-6 M). These data suggest that hyperpolarization of the cell membrane does not play a significant role in the relaxation of canine blood vessels induced by VIP.
Persistent Identifierhttp://hdl.handle.net/10722/171346
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorNakashima, Men_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:13:30Z-
dc.date.available2012-10-30T06:13:30Z-
dc.date.issued1996en_US
dc.identifier.citationFaseb Journal, 1996, v. 10 n. 3, p. A69en_US
dc.identifier.issn0892-6638en_US
dc.identifier.urihttp://hdl.handle.net/10722/171346-
dc.description.abstractThe present study was designed to determine the influence of the vascular endothelium on membrane hyperpolarization induced by vasoactive intestinal polypeptide (VIP) in smooth muscle cells of canine isolated blood vessels, and the potential contribution that these electrophysiological changes may make to the relaxant effects of VIP. Membrane potential was measured in isolated canine coronary arteries and saphenous veins, using glass microelectrodes, and isometric force was recorded in a conventional organ chamber apparatus. All experiments were performed in the presence of indomethacin and nitro-L-arginine. VIP (10-9 M - 10-7 M) induced concentration-dependent and endothelium-independent hyperpolarization of the saphenous vein. This response was abolished by glibenclamide (10-6 M). VIP did not induce hyperpolarization of the coronary arterial preparations either in the presence or absence of the endothelium. VIP caused concentration-dependent and endothelium-independent relaxations of rings of both canine arterial and venous preparations. The relaxation of the saphenous vein to VIP was not influenced by glibenclamide (10-6 M). These data suggest that hyperpolarization of the cell membrane does not play a significant role in the relaxation of canine blood vessels induced by VIP.en_US
dc.languageengen_US
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/en_US
dc.relation.ispartofFASEB Journalen_US
dc.titleMembrane hyperpolarization and relaxation of canine blood vessels to vasoactive intestinal polypeptideen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33748985844en_US
dc.identifier.volume10en_US
dc.identifier.issue3en_US
dc.identifier.spageA69en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNakashima, M=35599797500en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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