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- Publisher Website: 10.1038/sj.bjp.0706422
- Scopus: eid_2-s2.0-28944451629
- PMID: 16231002
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Article: Nongenomic responses to 17β-estradiol in male rat mesenteric arteries abolish intrinsic gender differences in vascular responses
Title | Nongenomic responses to 17β-estradiol in male rat mesenteric arteries abolish intrinsic gender differences in vascular responses |
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Authors | |
Keywords | 17Β-Estradiol Contraction Gender Nongenomic Rat Mesenteric Arteries Relaxation Vascular Smooth Muscle |
Issue Date | 2005 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1 |
Citation | British Journal Of Pharmacology, 2005, v. 146 n. 8, p. 1148-1155 How to Cite? |
Abstract | 1 The aim of the present study was to investigate the gender differences in the acute effects of 17β-estradiol on the rat superior mesenteric artery. 2 Isometric tension was measured in rings of mesenteric arteries from both male and female Sprague-Dawley rats. 3 Relaxation to acetylcholine was not significantly different between arteries (with endothelium) from male and female rats in the absence or presence of 17β-estradiol. After blockade of endothelium-dependent hyperpolarizations with apamin (0.3 μM) plus charybdotoxin (0.1 μM), acute exposure to 17β-estradiol (1 nM) for 30 min resulted in enhancement of relaxation to acetylcholine in arteries from male but not female rats. 4 After acute exposure to 17β-estradiol, mesenteric arteries from male rats were more sensitive to sodium nitroprusside than arteries from female rats. 5 Contractions of mesenteric arteries to phenylephrine and 9,11-dideoxy-11α,9α-epoxymethanoprostaglandin F 2α (U46619) were greater in arteries from male rats than female rats. This difference was not detected after acute exposure to 17β-estradiol. 6 In preparations without endothelium, the enhancement of relaxation and reduction in contraction in arteries from male rats were preserved. 7 These results suggest that there exists a gender difference in the response to the acute nongenomic modulatory effect of 17β-estradiol in rat mesenteric arteries. Arteries from male rats seem to be more sensitive to the modulatory effects of 17β-estradiol than arteries from female rats. The effect appears to be mainly at the level of the vascular smooth muscles. © 2005 Nature Publishing Group. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/171336 |
ISSN | 2023 Impact Factor: 6.8 2023 SCImago Journal Rankings: 2.119 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Keung, W | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.contributor.author | Man, RYK | en_US |
dc.date.accessioned | 2012-10-30T06:13:28Z | - |
dc.date.available | 2012-10-30T06:13:28Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | British Journal Of Pharmacology, 2005, v. 146 n. 8, p. 1148-1155 | en_US |
dc.identifier.issn | 0007-1188 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171336 | - |
dc.description.abstract | 1 The aim of the present study was to investigate the gender differences in the acute effects of 17β-estradiol on the rat superior mesenteric artery. 2 Isometric tension was measured in rings of mesenteric arteries from both male and female Sprague-Dawley rats. 3 Relaxation to acetylcholine was not significantly different between arteries (with endothelium) from male and female rats in the absence or presence of 17β-estradiol. After blockade of endothelium-dependent hyperpolarizations with apamin (0.3 μM) plus charybdotoxin (0.1 μM), acute exposure to 17β-estradiol (1 nM) for 30 min resulted in enhancement of relaxation to acetylcholine in arteries from male but not female rats. 4 After acute exposure to 17β-estradiol, mesenteric arteries from male rats were more sensitive to sodium nitroprusside than arteries from female rats. 5 Contractions of mesenteric arteries to phenylephrine and 9,11-dideoxy-11α,9α-epoxymethanoprostaglandin F 2α (U46619) were greater in arteries from male rats than female rats. This difference was not detected after acute exposure to 17β-estradiol. 6 In preparations without endothelium, the enhancement of relaxation and reduction in contraction in arteries from male rats were preserved. 7 These results suggest that there exists a gender difference in the response to the acute nongenomic modulatory effect of 17β-estradiol in rat mesenteric arteries. Arteries from male rats seem to be more sensitive to the modulatory effects of 17β-estradiol than arteries from female rats. The effect appears to be mainly at the level of the vascular smooth muscles. © 2005 Nature Publishing Group. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1 | en_US |
dc.relation.ispartof | British Journal of Pharmacology | en_US |
dc.subject | 17Β-Estradiol | en_US |
dc.subject | Contraction | en_US |
dc.subject | Gender | en_US |
dc.subject | Nongenomic | en_US |
dc.subject | Rat Mesenteric Arteries | en_US |
dc.subject | Relaxation | en_US |
dc.subject | Vascular Smooth Muscle | en_US |
dc.title | Nongenomic responses to 17β-estradiol in male rat mesenteric arteries abolish intrinsic gender differences in vascular responses | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.email | Man, RYK:rykman@hkucc.hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.identifier.authority | Man, RYK=rp00236 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1038/sj.bjp.0706422 | en_US |
dc.identifier.pmid | 16231002 | - |
dc.identifier.scopus | eid_2-s2.0-28944451629 | en_US |
dc.identifier.hkuros | 119252 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-28944451629&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 146 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.spage | 1148 | en_US |
dc.identifier.epage | 1155 | en_US |
dc.identifier.isi | WOS:000234080200011 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Keung, W=19337708900 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.scopusauthorid | Man, RYK=7004986435 | en_US |
dc.identifier.issnl | 0007-1188 | - |