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Article: Nongenomic responses to 17β-estradiol in male rat mesenteric arteries abolish intrinsic gender differences in vascular responses

TitleNongenomic responses to 17β-estradiol in male rat mesenteric arteries abolish intrinsic gender differences in vascular responses
Authors
Keywords17Β-Estradiol
Contraction
Gender
Nongenomic
Rat Mesenteric Arteries
Relaxation
Vascular Smooth Muscle
Issue Date2005
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1
Citation
British Journal Of Pharmacology, 2005, v. 146 n. 8, p. 1148-1155 How to Cite?
Abstract1 The aim of the present study was to investigate the gender differences in the acute effects of 17β-estradiol on the rat superior mesenteric artery. 2 Isometric tension was measured in rings of mesenteric arteries from both male and female Sprague-Dawley rats. 3 Relaxation to acetylcholine was not significantly different between arteries (with endothelium) from male and female rats in the absence or presence of 17β-estradiol. After blockade of endothelium-dependent hyperpolarizations with apamin (0.3 μM) plus charybdotoxin (0.1 μM), acute exposure to 17β-estradiol (1 nM) for 30 min resulted in enhancement of relaxation to acetylcholine in arteries from male but not female rats. 4 After acute exposure to 17β-estradiol, mesenteric arteries from male rats were more sensitive to sodium nitroprusside than arteries from female rats. 5 Contractions of mesenteric arteries to phenylephrine and 9,11-dideoxy-11α,9α-epoxymethanoprostaglandin F 2α (U46619) were greater in arteries from male rats than female rats. This difference was not detected after acute exposure to 17β-estradiol. 6 In preparations without endothelium, the enhancement of relaxation and reduction in contraction in arteries from male rats were preserved. 7 These results suggest that there exists a gender difference in the response to the acute nongenomic modulatory effect of 17β-estradiol in rat mesenteric arteries. Arteries from male rats seem to be more sensitive to the modulatory effects of 17β-estradiol than arteries from female rats. The effect appears to be mainly at the level of the vascular smooth muscles. © 2005 Nature Publishing Group. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/171336
ISSN
2015 Impact Factor: 5.259
2015 SCImago Journal Rankings: 2.368
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKeung, Wen_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorMan, RYKen_US
dc.date.accessioned2012-10-30T06:13:28Z-
dc.date.available2012-10-30T06:13:28Z-
dc.date.issued2005en_US
dc.identifier.citationBritish Journal Of Pharmacology, 2005, v. 146 n. 8, p. 1148-1155en_US
dc.identifier.issn0007-1188en_US
dc.identifier.urihttp://hdl.handle.net/10722/171336-
dc.description.abstract1 The aim of the present study was to investigate the gender differences in the acute effects of 17β-estradiol on the rat superior mesenteric artery. 2 Isometric tension was measured in rings of mesenteric arteries from both male and female Sprague-Dawley rats. 3 Relaxation to acetylcholine was not significantly different between arteries (with endothelium) from male and female rats in the absence or presence of 17β-estradiol. After blockade of endothelium-dependent hyperpolarizations with apamin (0.3 μM) plus charybdotoxin (0.1 μM), acute exposure to 17β-estradiol (1 nM) for 30 min resulted in enhancement of relaxation to acetylcholine in arteries from male but not female rats. 4 After acute exposure to 17β-estradiol, mesenteric arteries from male rats were more sensitive to sodium nitroprusside than arteries from female rats. 5 Contractions of mesenteric arteries to phenylephrine and 9,11-dideoxy-11α,9α-epoxymethanoprostaglandin F 2α (U46619) were greater in arteries from male rats than female rats. This difference was not detected after acute exposure to 17β-estradiol. 6 In preparations without endothelium, the enhancement of relaxation and reduction in contraction in arteries from male rats were preserved. 7 These results suggest that there exists a gender difference in the response to the acute nongenomic modulatory effect of 17β-estradiol in rat mesenteric arteries. Arteries from male rats seem to be more sensitive to the modulatory effects of 17β-estradiol than arteries from female rats. The effect appears to be mainly at the level of the vascular smooth muscles. © 2005 Nature Publishing Group. All rights reserved.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1en_US
dc.relation.ispartofBritish Journal of Pharmacologyen_US
dc.subject17Β-Estradiolen_US
dc.subjectContractionen_US
dc.subjectGenderen_US
dc.subjectNongenomicen_US
dc.subjectRat Mesenteric Arteriesen_US
dc.subjectRelaxationen_US
dc.subjectVascular Smooth Muscleen_US
dc.titleNongenomic responses to 17β-estradiol in male rat mesenteric arteries abolish intrinsic gender differences in vascular responsesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/sj.bjp.0706422en_US
dc.identifier.pmid16231002-
dc.identifier.scopuseid_2-s2.0-28944451629en_US
dc.identifier.hkuros119252-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-28944451629&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume146en_US
dc.identifier.issue8en_US
dc.identifier.spage1148en_US
dc.identifier.epage1155en_US
dc.identifier.isiWOS:000234080200011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridKeung, W=19337708900en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US

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