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Article: EDHF: A new pathway for endothelial and smooth muscle cells communication | Dialogue entre cellules endothéliales et cellules musculaires lisses

TitleEDHF: A new pathway for endothelial and smooth muscle cells communication | Dialogue entre cellules endothéliales et cellules musculaires lisses
Authors
Issue Date2003
Citation
Medecine/Sciences, 2003, v. 19 n. 12, p. 1242-1250 How to Cite?
AbstractVascular endothelial cells play a fundamental role in the control of vascular tone, and therefore in the control of local blood flow, by releasing various contracting (endothelin, prostaglandins) and relaxing (prostacycline, NO) factors. An additional mechanism involving the hyperpolarization of the vascular smooth muscle cells is observed mainly in the coronary vascular bed and in the periphery. This phenomenon was attributed to an elusive endothelial factor called endothelium-derived hyperpolarizing factor (EDHF). This mechanism is now better understood. It involves first an increase in the endothelial intracellular concentration of calcium, the activation of endothelial potassium channels and the resulting hyperpolarization of the endothelial cells. The hyperpolarization of the endothelial cells is transmitted to the smooth muscle cells by different pathways. This hyperpolarization propagates along the vessels not only via the smooth muscle cells but also via the endothelial cells. Therefore, the endothelial layer can also be considered as a conducting tissue. The discovery of specific inhibitors of the endothelial cell hyperpolarization allows the assessment of the contribution of EDHF-mediated responses in the control of vascular tone.
Persistent Identifierhttp://hdl.handle.net/10722/171309
ISSN
2015 Impact Factor: 0.384
2015 SCImago Journal Rankings: 0.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFélétou, Men_US
dc.contributor.authorBusse, Ren_US
dc.contributor.authorEdwards, Gen_US
dc.contributor.authorFleming, Ien_US
dc.contributor.authorWeston, AHen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:13:19Z-
dc.date.available2012-10-30T06:13:19Z-
dc.date.issued2003en_US
dc.identifier.citationMedecine/Sciences, 2003, v. 19 n. 12, p. 1242-1250en_US
dc.identifier.issn0767-0974en_US
dc.identifier.urihttp://hdl.handle.net/10722/171309-
dc.description.abstractVascular endothelial cells play a fundamental role in the control of vascular tone, and therefore in the control of local blood flow, by releasing various contracting (endothelin, prostaglandins) and relaxing (prostacycline, NO) factors. An additional mechanism involving the hyperpolarization of the vascular smooth muscle cells is observed mainly in the coronary vascular bed and in the periphery. This phenomenon was attributed to an elusive endothelial factor called endothelium-derived hyperpolarizing factor (EDHF). This mechanism is now better understood. It involves first an increase in the endothelial intracellular concentration of calcium, the activation of endothelial potassium channels and the resulting hyperpolarization of the endothelial cells. The hyperpolarization of the endothelial cells is transmitted to the smooth muscle cells by different pathways. This hyperpolarization propagates along the vessels not only via the smooth muscle cells but also via the endothelial cells. Therefore, the endothelial layer can also be considered as a conducting tissue. The discovery of specific inhibitors of the endothelial cell hyperpolarization allows the assessment of the contribution of EDHF-mediated responses in the control of vascular tone.en_US
dc.languageengen_US
dc.relation.ispartofMedecine/Sciencesen_US
dc.subject.meshBiological Factors - Pharmacologyen_US
dc.subject.meshCalcium - Pharmacokineticsen_US
dc.subject.meshCell Communicationen_US
dc.subject.meshEndothelial Cells - Physiologyen_US
dc.subject.meshEndothelium, Vascular - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMyocytes, Smooth Muscle - Physiologyen_US
dc.subject.meshPotassium Channels - Physiologyen_US
dc.titleEDHF: A new pathway for endothelial and smooth muscle cells communication | Dialogue entre cellules endothéliales et cellules musculaires lissesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1051/medsci/200319121242-
dc.identifier.pmid14691749-
dc.identifier.scopuseid_2-s2.0-0346847537en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0346847537&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume19en_US
dc.identifier.issue12en_US
dc.identifier.spage1242en_US
dc.identifier.epage1250en_US
dc.identifier.isiWOS:000187353800016-
dc.identifier.scopusauthoridFélétou, M=7006461826en_US
dc.identifier.scopusauthoridBusse, R=7102661981en_US
dc.identifier.scopusauthoridEdwards, G=7402317535en_US
dc.identifier.scopusauthoridFleming, I=7102053742en_US
dc.identifier.scopusauthoridWeston, AH=7102913361en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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