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Article: 3-Morpholinosydnonimine (SIN-1) and K+ channels in smooth muscle cells of the rabbit and guinea pig carotid arteries

Title3-Morpholinosydnonimine (SIN-1) and K+ channels in smooth muscle cells of the rabbit and guinea pig carotid arteries
Authors
Issue Date2000
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 2000, v. 399 n. 1, p. 9-16 How to Cite?
AbstractExperiments were designed to determine the subtype of K+ channels activated by the nitrovasodilator 3-morpholinosydnonimine (SIN-1) in smooth muscle cells of the rabbit and guinea pig carotid arteries. Membrane potential was recorded in isolated segments with intracellular microelectrode and K+ currents in freshly dissociated smooth muscle cells, with the patch-clamp technique. In the guinea pig carotid artery, SIN-1 caused a glibenclamide-sensitive hyperpolarization. The nitrovasodilator did not affect the whole-cell K+ current, but activated a glibenclamide-sensitive K+ current. In the rabbit carotid artery, SIN-1 induced only an iberiotoxin-sensitive repolarization in phenylephrine-depolarized tissue and in isolated cells, enhanced the activity of an iberiotoxin-sensitive K+ current. These findings demonstrate that the population of K+ channels activated by nitric oxide (NO) is species-dependent and support the conclusion that, in the guinea pig carotid artery, in contrast to the rabbit carotid artery, the release of NO cannot account for the responses attributed to endothelium-derived hyperpolarizing factor (EDHF). Copyright (C) 2000 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/171303
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQuignard, JFen_US
dc.contributor.authorFélétou, Men_US
dc.contributor.authorCorriu, Cen_US
dc.contributor.authorChataigneau, Ten_US
dc.contributor.authorEdwards, Gen_US
dc.contributor.authorWeston, AHen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:13:17Z-
dc.date.available2012-10-30T06:13:17Z-
dc.date.issued2000en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 2000, v. 399 n. 1, p. 9-16en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/171303-
dc.description.abstractExperiments were designed to determine the subtype of K+ channels activated by the nitrovasodilator 3-morpholinosydnonimine (SIN-1) in smooth muscle cells of the rabbit and guinea pig carotid arteries. Membrane potential was recorded in isolated segments with intracellular microelectrode and K+ currents in freshly dissociated smooth muscle cells, with the patch-clamp technique. In the guinea pig carotid artery, SIN-1 caused a glibenclamide-sensitive hyperpolarization. The nitrovasodilator did not affect the whole-cell K+ current, but activated a glibenclamide-sensitive K+ current. In the rabbit carotid artery, SIN-1 induced only an iberiotoxin-sensitive repolarization in phenylephrine-depolarized tissue and in isolated cells, enhanced the activity of an iberiotoxin-sensitive K+ current. These findings demonstrate that the population of K+ channels activated by nitric oxide (NO) is species-dependent and support the conclusion that, in the guinea pig carotid artery, in contrast to the rabbit carotid artery, the release of NO cannot account for the responses attributed to endothelium-derived hyperpolarizing factor (EDHF). Copyright (C) 2000 Elsevier Science B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Pharmacologyen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshMaleen_US
dc.subject.meshMicroelectrodesen_US
dc.subject.meshMolsidomine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshNitric Oxide - Physiologyen_US
dc.subject.meshNitric Oxide Donors - Pharmacologyen_US
dc.subject.meshPatch-Clamp Techniquesen_US
dc.subject.meshPotassium Channels - Drug Effectsen_US
dc.subject.meshRabbitsen_US
dc.subject.meshSpecies Specificityen_US
dc.title3-Morpholinosydnonimine (SIN-1) and K+ channels in smooth muscle cells of the rabbit and guinea pig carotid arteriesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0014-2999(00)00372-1en_US
dc.identifier.pmid10876017-
dc.identifier.scopuseid_2-s2.0-0342699645en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0342699645&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume399en_US
dc.identifier.issue1en_US
dc.identifier.spage9en_US
dc.identifier.epage16en_US
dc.identifier.isiWOS:000087975400002-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridQuignard, JF=13606215800en_US
dc.identifier.scopusauthoridFélétou, M=7006461826en_US
dc.identifier.scopusauthoridCorriu, C=6602961498en_US
dc.identifier.scopusauthoridChataigneau, T=6602561430en_US
dc.identifier.scopusauthoridEdwards, G=7402317535en_US
dc.identifier.scopusauthoridWeston, AH=7102913361en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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