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Article: Endothelium-dependent responses to platelets and serotonin in spontaneously hypertensive rats
Title | Endothelium-dependent responses to platelets and serotonin in spontaneously hypertensive rats |
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Authors | |
Keywords | Adenosine diphosphate Endothelium-derived contracting factors Endothelium-derived relaxing factors Hypertension Norepinephrine Rat thoracic aorta Serotonin Thrombin |
Issue Date | 1986 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/ |
Citation | Hypertension, 1986, v. 8 n. 6 II MONOGR. 122, p. II55-II60 How to Cite? |
Abstract | We studied endothelium-dependent responses to substances released from aggregating platelets in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). Rings of thoracic aorta with and without endothelium were taken from adult rats and suspended for isometric tension recording in organ chambers containing modified Krebs-Ringer bicarbonate solution. Aggregating platelets caused statistically similar contractions in rings without endothelium in both strains. In rings with endothelium from SHR the contractions were significantly more pronounced than in rings with endothelium from WKY. In contracted rings with endothelium, serotonin caused a slight relaxation at lower concentrations but contraction at higher concentrations; only contractions were seen in rings without endothelium. The higher concentrations of the monoamine caused contractions, which in the SHR but not in the WKY were larger in the presence than in the absence of endothelium. In both strains adenosine diphosphate induced concentration-dependent relaxation in rings with endothelium but not in those without it; at high concentrations of adenosine diphosphate, the relaxation responses were significantly smaller in the SHR than in the WKY. Endothelium-dependent relaxation in response to thrombin did not differ in the two strains. The increased contraction in response to aggregating platelets and serotonin and the decreased relaxation in response to adenosine diphosphate in the SHR suggest that functional changes occur in the endothelium in this model of hypertension, possibly because of the release of one or more endothelium-derived contracting factors. |
Persistent Identifier | http://hdl.handle.net/10722/171295 |
ISSN | 2023 Impact Factor: 6.9 2023 SCImago Journal Rankings: 2.827 |
DC Field | Value | Language |
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dc.contributor.author | Luscher, TF | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:13:14Z | - |
dc.date.available | 2012-10-30T06:13:14Z | - |
dc.date.issued | 1986 | en_US |
dc.identifier.citation | Hypertension, 1986, v. 8 n. 6 II MONOGR. 122, p. II55-II60 | en_US |
dc.identifier.issn | 0194-911X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171295 | - |
dc.description.abstract | We studied endothelium-dependent responses to substances released from aggregating platelets in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). Rings of thoracic aorta with and without endothelium were taken from adult rats and suspended for isometric tension recording in organ chambers containing modified Krebs-Ringer bicarbonate solution. Aggregating platelets caused statistically similar contractions in rings without endothelium in both strains. In rings with endothelium from SHR the contractions were significantly more pronounced than in rings with endothelium from WKY. In contracted rings with endothelium, serotonin caused a slight relaxation at lower concentrations but contraction at higher concentrations; only contractions were seen in rings without endothelium. The higher concentrations of the monoamine caused contractions, which in the SHR but not in the WKY were larger in the presence than in the absence of endothelium. In both strains adenosine diphosphate induced concentration-dependent relaxation in rings with endothelium but not in those without it; at high concentrations of adenosine diphosphate, the relaxation responses were significantly smaller in the SHR than in the WKY. Endothelium-dependent relaxation in response to thrombin did not differ in the two strains. The increased contraction in response to aggregating platelets and serotonin and the decreased relaxation in response to adenosine diphosphate in the SHR suggest that functional changes occur in the endothelium in this model of hypertension, possibly because of the release of one or more endothelium-derived contracting factors. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/ | en_US |
dc.relation.ispartof | Hypertension | en_US |
dc.subject | Adenosine diphosphate | - |
dc.subject | Endothelium-derived contracting factors | - |
dc.subject | Endothelium-derived relaxing factors | - |
dc.subject | Hypertension | - |
dc.subject | Norepinephrine | - |
dc.subject | Rat thoracic aorta | - |
dc.subject | Serotonin | - |
dc.subject | Thrombin | - |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Adenosine Diphosphate - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Platelets - Physiology | en_US |
dc.subject.mesh | Dinoprost | en_US |
dc.subject.mesh | Endothelium - Physiology | en_US |
dc.subject.mesh | Hypertension - Physiopathology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Nitric Oxide | en_US |
dc.subject.mesh | Platelet Aggregation | en_US |
dc.subject.mesh | Prostaglandins F - Pharmacology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Shr | en_US |
dc.subject.mesh | Rats, Inbred Wky | en_US |
dc.subject.mesh | Serotonin - Pharmacology | en_US |
dc.subject.mesh | Thrombin - Pharmacology | en_US |
dc.subject.mesh | Vasoconstriction - Drug Effects | en_US |
dc.subject.mesh | Vasodilator Agents - Physiology | en_US |
dc.title | Endothelium-dependent responses to platelets and serotonin in spontaneously hypertensive rats | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 3487506 | - |
dc.identifier.scopus | eid_2-s2.0-0037834577 | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 6 II MONOGR. 122 | en_US |
dc.identifier.spage | II55 | en_US |
dc.identifier.epage | II60 | en_US |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Luscher, TF=18935805600 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0194-911X | - |