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Article: EDHF: Bringing the concepts together

TitleEDHF: Bringing the concepts together
Authors
Issue Date2002
PublisherElsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/tips
Citation
Trends In Pharmacological Sciences, 2002, v. 23 n. 8, p. 374-380 How to Cite?
AbstractEndothelial cells synthesize and release vasoactive mediators in response to various neurohumoural substances (e.g. bradykinin or acetylcholine) and physical stimuli (e.g. cyclic stretch or fluid shear stress). The best-characterized endothelium-derived relaxing factors are nitric oxide and prostacyclin. However, an additional relaxant pathway associated with smooth muscle hyperpolarization also exists. This hyperpolarization was originally attributed to the release of an endothelium-derived hyperpolarizing factor (EDHF) that diffuses to and activates smooth muscle K + channels. More recent evidence suggests that endothelial cell receptor activation by these neurohumoural substances opens endothelial cell K + channels. Several mechanisms have been proposed to link this pivotal step to the subsequent smooth muscle hyperpolarization. The main concepts are considered in detail in this review.
Persistent Identifierhttp://hdl.handle.net/10722/171282
ISSN
2015 Impact Factor: 11.84
2015 SCImago Journal Rankings: 5.492
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBusse, Ren_US
dc.contributor.authorEdwards, Gen_US
dc.contributor.authorFélétou, Men_US
dc.contributor.authorFleming, Ien_US
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorWeston, AHen_US
dc.date.accessioned2012-10-30T06:13:09Z-
dc.date.available2012-10-30T06:13:09Z-
dc.date.issued2002en_US
dc.identifier.citationTrends In Pharmacological Sciences, 2002, v. 23 n. 8, p. 374-380en_US
dc.identifier.issn0165-6147en_US
dc.identifier.urihttp://hdl.handle.net/10722/171282-
dc.description.abstractEndothelial cells synthesize and release vasoactive mediators in response to various neurohumoural substances (e.g. bradykinin or acetylcholine) and physical stimuli (e.g. cyclic stretch or fluid shear stress). The best-characterized endothelium-derived relaxing factors are nitric oxide and prostacyclin. However, an additional relaxant pathway associated with smooth muscle hyperpolarization also exists. This hyperpolarization was originally attributed to the release of an endothelium-derived hyperpolarizing factor (EDHF) that diffuses to and activates smooth muscle K + channels. More recent evidence suggests that endothelial cell receptor activation by these neurohumoural substances opens endothelial cell K + channels. Several mechanisms have been proposed to link this pivotal step to the subsequent smooth muscle hyperpolarization. The main concepts are considered in detail in this review.en_US
dc.languageengen_US
dc.publisherElsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/tipsen_US
dc.relation.ispartofTrends in Pharmacological Sciencesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Factors - Physiologyen_US
dc.subject.meshEndothelium, Vascular - Metabolism - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshPotassium Channels - Physiologyen_US
dc.titleEDHF: Bringing the concepts togetheren_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-6147(02)02050-3en_US
dc.identifier.pmid12377579-
dc.identifier.scopuseid_2-s2.0-0036696313en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036696313&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume23en_US
dc.identifier.issue8en_US
dc.identifier.spage374en_US
dc.identifier.epage380en_US
dc.identifier.isiWOS:000177280900010-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridBusse, R=7102661981en_US
dc.identifier.scopusauthoridEdwards, G=7402317535en_US
dc.identifier.scopusauthoridFélétou, M=7006461826en_US
dc.identifier.scopusauthoridFleming, I=7102053742en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridWeston, AH=7102913361en_US
dc.identifier.citeulike8779628-

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