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Article: Hypercholesterolemia increases coronary endothelial dysfunction, lipid content, and accelerated atherosclerosis after heart transplantation

TitleHypercholesterolemia increases coronary endothelial dysfunction, lipid content, and accelerated atherosclerosis after heart transplantation
Authors
Issue Date2000
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.lww.com/product/?1079-5642
Citation
Arteriosclerosis, Thrombosis, And Vascular Biology, 2000, v. 20 n. 3, p. 728-736 How to Cite?
AbstractHyperlipidemia may increase endothelial damage and promote accelerated atherogenesis in graft coronary vasculopathy. To study the effects of hypercholesterolemia on coronary endothelial dysfunction, intimal hyperplasia, and lipid content, a porcine model of heterotopic heart transplantation, allowing nonacute rejection without immunosuppressive drugs, was used. A high cholesterol diet was fed to donor and recipient swine 1 month before and after transplantation. The endothelial function of coronary arteries of native and transplanted hearts from cholesterol-fed animals was studied in organ chambers 30 days after implantation and compared with endothelial function in arteries from animals fed a normal diet. The total serum cholesterol increased 3-fold in donors and recipients. Endothelium- dependent relaxations to serotonin, to the α2-adrenergic agonist UK14,304, and to the direct G-protein activator sodium fluoride were decreased significantly in allografted hearts compared with native hearts from both groups. Relaxations to the calcium ionophore A23187 and bradykinin were decreased significantly in allografts from animals fed the high cholesterol diet. The prevalence of intimal hyperplasia was significantly increased in coronary arteries from hypercholesterolemic swine. There was a significant increase in the lipid content of allograft arteries of hypercholesterolemic recipients. Hypercholesterolemia causes a general coronary endothelial dysfunction, increases the prevalence of intimal hyperplasia, and augments the incorporation of lipids in the vascular wall after heart transplantation. Hyperlipidemia accelerates graft coronary atherosclerosis through its effects on the endothelium.
Persistent Identifierhttp://hdl.handle.net/10722/171240
ISSN
2015 Impact Factor: 5.969
2015 SCImago Journal Rankings: 3.356
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPerrault, LPen_US
dc.contributor.authorMahlberg, Fen_US
dc.contributor.authorBreugnot, Cen_US
dc.contributor.authorBidouard, JPen_US
dc.contributor.authorVilleneuve, Nen_US
dc.contributor.authorVilaine, JPen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:53Z-
dc.date.available2012-10-30T06:12:53Z-
dc.date.issued2000en_US
dc.identifier.citationArteriosclerosis, Thrombosis, And Vascular Biology, 2000, v. 20 n. 3, p. 728-736en_US
dc.identifier.issn1079-5642en_US
dc.identifier.urihttp://hdl.handle.net/10722/171240-
dc.description.abstractHyperlipidemia may increase endothelial damage and promote accelerated atherogenesis in graft coronary vasculopathy. To study the effects of hypercholesterolemia on coronary endothelial dysfunction, intimal hyperplasia, and lipid content, a porcine model of heterotopic heart transplantation, allowing nonacute rejection without immunosuppressive drugs, was used. A high cholesterol diet was fed to donor and recipient swine 1 month before and after transplantation. The endothelial function of coronary arteries of native and transplanted hearts from cholesterol-fed animals was studied in organ chambers 30 days after implantation and compared with endothelial function in arteries from animals fed a normal diet. The total serum cholesterol increased 3-fold in donors and recipients. Endothelium- dependent relaxations to serotonin, to the α2-adrenergic agonist UK14,304, and to the direct G-protein activator sodium fluoride were decreased significantly in allografted hearts compared with native hearts from both groups. Relaxations to the calcium ionophore A23187 and bradykinin were decreased significantly in allografts from animals fed the high cholesterol diet. The prevalence of intimal hyperplasia was significantly increased in coronary arteries from hypercholesterolemic swine. There was a significant increase in the lipid content of allograft arteries of hypercholesterolemic recipients. Hypercholesterolemia causes a general coronary endothelial dysfunction, increases the prevalence of intimal hyperplasia, and augments the incorporation of lipids in the vascular wall after heart transplantation. Hyperlipidemia accelerates graft coronary atherosclerosis through its effects on the endothelium.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.lww.com/product/?1079-5642en_US
dc.relation.ispartofArteriosclerosis, Thrombosis, and Vascular Biologyen_US
dc.subject.meshAdrenergic Alpha-Agonists - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArteriosclerosis - Metabolism - Pathology - Physiopathologyen_US
dc.subject.meshBiological Transport - Drug Effectsen_US
dc.subject.meshCalcimycin - Pharmacologyen_US
dc.subject.meshCalcium - Metabolismen_US
dc.subject.meshCholesterol, Hdl - Analysis - Blooden_US
dc.subject.meshCholesterol, Ldl - Analysis - Blooden_US
dc.subject.meshCoronary Vessels - Drug Effects - Metabolism - Physiopathologyen_US
dc.subject.meshDiet, Atherogenicen_US
dc.subject.meshDinoprost - Pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEndothelium, Vascular - Metabolism - Pathology - Physiopathologyen_US
dc.subject.meshErythrocyte Counten_US
dc.subject.meshFemaleen_US
dc.subject.meshFree Radical Scavengers - Pharmacologyen_US
dc.subject.meshHeart Transplantationen_US
dc.subject.meshHematocriten_US
dc.subject.meshHemoglobinsen_US
dc.subject.meshHypercholesterolemia - Metabolism - Physiopathologyen_US
dc.subject.meshHyperplasiaen_US
dc.subject.meshIonophores - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardium - Metabolismen_US
dc.subject.meshPostoperative Perioden_US
dc.subject.meshPotassium Chloride - Pharmacologyen_US
dc.subject.meshQuinoxalines - Pharmacologyen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.subject.meshSwineen_US
dc.subject.meshTransplantation, Homologousen_US
dc.subject.meshTunica Intima - Metabolism - Pathologyen_US
dc.subject.meshVasodilation - Drug Effects - Physiologyen_US
dc.titleHypercholesterolemia increases coronary endothelial dysfunction, lipid content, and accelerated atherosclerosis after heart transplantationen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1161/01.ATV.20.3.728-
dc.identifier.pmid10712398-
dc.identifier.scopuseid_2-s2.0-0034020375en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034020375&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue3en_US
dc.identifier.spage728en_US
dc.identifier.epage736en_US
dc.identifier.isiWOS:000085834100019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridPerrault, LP=7004370552en_US
dc.identifier.scopusauthoridMahlberg, F=6701623155en_US
dc.identifier.scopusauthoridBreugnot, C=6603192478en_US
dc.identifier.scopusauthoridBidouard, JP=6601955808en_US
dc.identifier.scopusauthoridVilleneuve, N=7003458215en_US
dc.identifier.scopusauthoridVilaine, JP=7004617134en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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