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- Publisher Website: 10.1007/PL00005310
- Scopus: eid_2-s2.0-0032238024
- PMID: 9879727
- WOS: WOS:000077520200011
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Article: Chronic 17β-estradiol augments relaxant role of basal nitric oxide in blood vessels from rats with heart failure
Title | Chronic 17β-estradiol augments relaxant role of basal nitric oxide in blood vessels from rats with heart failure |
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Authors | |
Keywords | Acetylcholine Cardiac output Chronic heart failure Endothelium-derived relaxing factor Left ventricular filling pressure 17β-Estradiol N(G)-nitro-L-arginine methyl ester (L- NAME) Sodium nitroprusside |
Issue Date | 1998 |
Publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00210/index.htm |
Citation | Naunyn-Schmiedeberg's Archives Of Pharmacology, 1998, v. 358 n. 6, p. 671-677 How to Cite? |
Abstract | The effects of chronic 17β-estradiol on endothelium-dependent relaxation to acetylcholine (ACh) and contraction to N(G)-nitro-L-arginine methyl ester (L-NAME), and endothelium-independent relaxation to sodium nitroprusside (SNP) were examined on blood vessels from rats with chronic heart failure (CHF). Two groups of ovariectomized female (50-60 days) rats were implanted with pellets containing 17β-estradiol (25 μg/day) or vehicle, and given ligation of the left main coronary artery 1 week later. Another group of ovariectomized rats was implanted with vehicle pellets, and sham-operated. After 7 weeks, thoracic aortic rings, pulmonary artery rings, and portal vein strips were prepared for in vitro studies. Relative to sham- operated rats treated with the vehicle, vessels from vehicle-treated, coronary-ligated rats had similar relaxation to ACh and SNP but reduced response to L-NAME that was significant (P<0.05) for the aorta and portal vein but not pulmonary artery. Treatment of ligated rats with 17β-estradiol augmented responses to L-NAME in the aorta, pulmonary artery and portal vein to values above those in sham-operated rat. 17β-Estradiol did not affect relaxation of any vessels to SNP and increased maximum relaxation to ACh only in the portal vein. Hence, 17β-estradiol enhances the relaxant role of basal nitric oxide in CHF. |
Persistent Identifier | http://hdl.handle.net/10722/171213 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.735 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nekooeian, AA | en_US |
dc.contributor.author | Lim, SL | en_US |
dc.contributor.author | Man, RYK | en_US |
dc.contributor.author | Pang, CCY | en_US |
dc.date.accessioned | 2012-10-30T06:12:44Z | - |
dc.date.available | 2012-10-30T06:12:44Z | - |
dc.date.issued | 1998 | en_US |
dc.identifier.citation | Naunyn-Schmiedeberg's Archives Of Pharmacology, 1998, v. 358 n. 6, p. 671-677 | en_US |
dc.identifier.issn | 0028-1298 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171213 | - |
dc.description.abstract | The effects of chronic 17β-estradiol on endothelium-dependent relaxation to acetylcholine (ACh) and contraction to N(G)-nitro-L-arginine methyl ester (L-NAME), and endothelium-independent relaxation to sodium nitroprusside (SNP) were examined on blood vessels from rats with chronic heart failure (CHF). Two groups of ovariectomized female (50-60 days) rats were implanted with pellets containing 17β-estradiol (25 μg/day) or vehicle, and given ligation of the left main coronary artery 1 week later. Another group of ovariectomized rats was implanted with vehicle pellets, and sham-operated. After 7 weeks, thoracic aortic rings, pulmonary artery rings, and portal vein strips were prepared for in vitro studies. Relative to sham- operated rats treated with the vehicle, vessels from vehicle-treated, coronary-ligated rats had similar relaxation to ACh and SNP but reduced response to L-NAME that was significant (P<0.05) for the aorta and portal vein but not pulmonary artery. Treatment of ligated rats with 17β-estradiol augmented responses to L-NAME in the aorta, pulmonary artery and portal vein to values above those in sham-operated rat. 17β-Estradiol did not affect relaxation of any vessels to SNP and increased maximum relaxation to ACh only in the portal vein. Hence, 17β-estradiol enhances the relaxant role of basal nitric oxide in CHF. | en_US |
dc.language | eng | en_US |
dc.publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00210/index.htm | en_US |
dc.relation.ispartof | Naunyn-Schmiedeberg's Archives of Pharmacology | en_US |
dc.subject | Acetylcholine | - |
dc.subject | Cardiac output | - |
dc.subject | Chronic heart failure | - |
dc.subject | Endothelium-derived relaxing factor | - |
dc.subject | Left ventricular filling pressure 17β-Estradiol | - |
dc.subject | N(G)-nitro-L-arginine methyl ester (L- NAME) | - |
dc.subject | Sodium nitroprusside | - |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Anesthesia | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Aorta, Thoracic - Drug Effects | en_US |
dc.subject.mesh | Blood Vessels - Drug Effects | en_US |
dc.subject.mesh | Drug Synergism | en_US |
dc.subject.mesh | Estradiol - Pharmacology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Heart Failure - Physiopathology | en_US |
dc.subject.mesh | Ng-Nitroarginine Methyl Ester - Pharmacology | en_US |
dc.subject.mesh | Nitric Oxide - Pharmacology | en_US |
dc.subject.mesh | Nitroprusside - Pharmacology | en_US |
dc.subject.mesh | Portal Vein - Drug Effects | en_US |
dc.subject.mesh | Pulmonary Artery - Drug Effects | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley - Surgery | en_US |
dc.subject.mesh | Time Factors | en_US |
dc.title | Chronic 17β-estradiol augments relaxant role of basal nitric oxide in blood vessels from rats with heart failure | en_US |
dc.type | Article | en_US |
dc.identifier.email | Man, RYK:rykman@hkucc.hku.hk | en_US |
dc.identifier.authority | Man, RYK=rp00236 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/PL00005310 | - |
dc.identifier.pmid | 9879727 | - |
dc.identifier.scopus | eid_2-s2.0-0032238024 | en_US |
dc.identifier.hkuros | 41161 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0032238024&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 358 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 671 | en_US |
dc.identifier.epage | 677 | en_US |
dc.identifier.isi | WOS:000077520200011 | - |
dc.publisher.place | Germany | en_US |
dc.identifier.scopusauthorid | Nekooeian, AA=6603144872 | en_US |
dc.identifier.scopusauthorid | Lim, SL=7404080728 | en_US |
dc.identifier.scopusauthorid | Man, RYK=7004986435 | en_US |
dc.identifier.scopusauthorid | Pang, CCY=7201425219 | en_US |
dc.identifier.issnl | 0028-1298 | - |