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Article: Chronic 17β-estradiol augments relaxant role of basal nitric oxide in blood vessels from rats with heart failure

TitleChronic 17β-estradiol augments relaxant role of basal nitric oxide in blood vessels from rats with heart failure
Authors
Issue Date1998
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00210/index.htm
Citation
Naunyn-Schmiedeberg's Archives Of Pharmacology, 1998, v. 358 n. 6, p. 671-677 How to Cite?
AbstractThe effects of chronic 17β-estradiol on endothelium-dependent relaxation to acetylcholine (ACh) and contraction to N(G)-nitro-L-arginine methyl ester (L-NAME), and endothelium-independent relaxation to sodium nitroprusside (SNP) were examined on blood vessels from rats with chronic heart failure (CHF). Two groups of ovariectomized female (50-60 days) rats were implanted with pellets containing 17β-estradiol (25 μg/day) or vehicle, and given ligation of the left main coronary artery 1 week later. Another group of ovariectomized rats was implanted with vehicle pellets, and sham-operated. After 7 weeks, thoracic aortic rings, pulmonary artery rings, and portal vein strips were prepared for in vitro studies. Relative to sham- operated rats treated with the vehicle, vessels from vehicle-treated, coronary-ligated rats had similar relaxation to ACh and SNP but reduced response to L-NAME that was significant (P<0.05) for the aorta and portal vein but not pulmonary artery. Treatment of ligated rats with 17β-estradiol augmented responses to L-NAME in the aorta, pulmonary artery and portal vein to values above those in sham-operated rat. 17β-Estradiol did not affect relaxation of any vessels to SNP and increased maximum relaxation to ACh only in the portal vein. Hence, 17β-estradiol enhances the relaxant role of basal nitric oxide in CHF.
Persistent Identifierhttp://hdl.handle.net/10722/171213
ISSN
2015 Impact Factor: 2.376
2015 SCImago Journal Rankings: 0.859
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNekooeian, AAen_US
dc.contributor.authorLim, SLen_US
dc.contributor.authorMan, RYKen_US
dc.contributor.authorPang, CCYen_US
dc.date.accessioned2012-10-30T06:12:44Z-
dc.date.available2012-10-30T06:12:44Z-
dc.date.issued1998en_US
dc.identifier.citationNaunyn-Schmiedeberg's Archives Of Pharmacology, 1998, v. 358 n. 6, p. 671-677en_US
dc.identifier.issn0028-1298en_US
dc.identifier.urihttp://hdl.handle.net/10722/171213-
dc.description.abstractThe effects of chronic 17β-estradiol on endothelium-dependent relaxation to acetylcholine (ACh) and contraction to N(G)-nitro-L-arginine methyl ester (L-NAME), and endothelium-independent relaxation to sodium nitroprusside (SNP) were examined on blood vessels from rats with chronic heart failure (CHF). Two groups of ovariectomized female (50-60 days) rats were implanted with pellets containing 17β-estradiol (25 μg/day) or vehicle, and given ligation of the left main coronary artery 1 week later. Another group of ovariectomized rats was implanted with vehicle pellets, and sham-operated. After 7 weeks, thoracic aortic rings, pulmonary artery rings, and portal vein strips were prepared for in vitro studies. Relative to sham- operated rats treated with the vehicle, vessels from vehicle-treated, coronary-ligated rats had similar relaxation to ACh and SNP but reduced response to L-NAME that was significant (P<0.05) for the aorta and portal vein but not pulmonary artery. Treatment of ligated rats with 17β-estradiol augmented responses to L-NAME in the aorta, pulmonary artery and portal vein to values above those in sham-operated rat. 17β-Estradiol did not affect relaxation of any vessels to SNP and increased maximum relaxation to ACh only in the portal vein. Hence, 17β-estradiol enhances the relaxant role of basal nitric oxide in CHF.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00210/index.htmen_US
dc.relation.ispartofNaunyn-Schmiedeberg's Archives of Pharmacologyen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnesthesiaen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAorta, Thoracic - Drug Effectsen_US
dc.subject.meshBlood Vessels - Drug Effectsen_US
dc.subject.meshDrug Synergismen_US
dc.subject.meshEstradiol - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Failure - Physiopathologyen_US
dc.subject.meshNg-Nitroarginine Methyl Ester - Pharmacologyen_US
dc.subject.meshNitric Oxide - Pharmacologyen_US
dc.subject.meshNitroprusside - Pharmacologyen_US
dc.subject.meshPortal Vein - Drug Effectsen_US
dc.subject.meshPulmonary Artery - Drug Effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawley - Surgeryen_US
dc.subject.meshTime Factorsen_US
dc.titleChronic 17β-estradiol augments relaxant role of basal nitric oxide in blood vessels from rats with heart failureen_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/PL00005310-
dc.identifier.pmid9879727-
dc.identifier.scopuseid_2-s2.0-0032238024en_US
dc.identifier.hkuros41161-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032238024&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume358en_US
dc.identifier.issue6en_US
dc.identifier.spage671en_US
dc.identifier.epage677en_US
dc.identifier.isiWOS:000077520200011-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridNekooeian, AA=6603144872en_US
dc.identifier.scopusauthoridLim, SL=7404080728en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US
dc.identifier.scopusauthoridPang, CCY=7201425219en_US

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