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Article: Hyperpolarization and relaxation of canine vascular smooth muscle to vasoactive intestinal polypeptide

TitleHyperpolarization and relaxation of canine vascular smooth muscle to vasoactive intestinal polypeptide
Authors
Issue Date1997
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1997, v. 30 n. 3, p. 273-277 How to Cite?
AbstractThis study was designed to determine the influence of the endothelium on the hyperpolarization induced by vasoactive intestinal polypeptide (VIP) in smooth muscle cells of canine blood vessels, and the potential contribution that these electrophysiologic changes may make to the relaxant effects of VIP. Membrane potential was measured in isolated canine coronary arteries and saphenous veins, using glass microelectrodes. Isometric force was recorded in a conventional organ chamber. All experiments were performed in the presence of indomethacin. VIP induced concentration-dependent and endothelium- independent hyperpolarization of the saphenous vein. This response was abolished by glibenclamide. VIP did not induce hyperpolarization of coronary arterial smooth muscle either in the presence or absence of the endothelium. VIP caused concentration-dependent and endothelium-independent relaxations of both arterial and venous rings. The relaxation of the saphenous vein to VIP was not influenced by glibenclamide. These data suggest that hyperpolarization of the cell membrane does not play a significant role in the relaxation of canine blood vessels to VIP.
Persistent Identifierhttp://hdl.handle.net/10722/171204
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNakashima, Men_US
dc.contributor.authorMorrison, KJen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:41Z-
dc.date.available2012-10-30T06:12:41Z-
dc.date.issued1997en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1997, v. 30 n. 3, p. 273-277en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/171204-
dc.description.abstractThis study was designed to determine the influence of the endothelium on the hyperpolarization induced by vasoactive intestinal polypeptide (VIP) in smooth muscle cells of canine blood vessels, and the potential contribution that these electrophysiologic changes may make to the relaxant effects of VIP. Membrane potential was measured in isolated canine coronary arteries and saphenous veins, using glass microelectrodes. Isometric force was recorded in a conventional organ chamber. All experiments were performed in the presence of indomethacin. VIP induced concentration-dependent and endothelium- independent hyperpolarization of the saphenous vein. This response was abolished by glibenclamide. VIP did not induce hyperpolarization of coronary arterial smooth muscle either in the presence or absence of the endothelium. VIP caused concentration-dependent and endothelium-independent relaxations of both arterial and venous rings. The relaxation of the saphenous vein to VIP was not influenced by glibenclamide. These data suggest that hyperpolarization of the cell membrane does not play a significant role in the relaxation of canine blood vessels to VIP.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Factors - Pharmacologyen_US
dc.subject.meshCoronary Vessels - Drug Effects - Physiologyen_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelium, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Potentials - Drug Effects - Physiologyen_US
dc.subject.meshMuscle Relaxation - Drug Effects - Physiologyen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshNitric Oxide - Pharmacologyen_US
dc.subject.meshSaphenous Vein - Drug Effects - Physiologyen_US
dc.subject.meshVasoactive Intestinal Peptide - Pharmacologyen_US
dc.titleHyperpolarization and relaxation of canine vascular smooth muscle to vasoactive intestinal polypeptideen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005344-199709000-00001en_US
dc.identifier.pmid9300308-
dc.identifier.scopuseid_2-s2.0-0031469323en_US
dc.identifier.volume30en_US
dc.identifier.issue3en_US
dc.identifier.spage273en_US
dc.identifier.epage277en_US
dc.identifier.isiWOS:A1997YK70300001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNakashima, M=35599797500en_US
dc.identifier.scopusauthoridMorrison, KJ=7102484828en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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