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Article: Vascular endothelium: Vasoactive mediators

TitleVascular endothelium: Vasoactive mediators
Authors
Issue Date1996
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/pcad
Citation
Progress In Cardiovascular Diseases, 1996, v. 39 n. 3, p. 229-238 How to Cite?
AbstractIn most blood vessels, the endothelium generates both vasodilator and growth-stabilizing mediators under normal physiological circumstances. The vasodilator influence of the endothelium modulates the vasoconstriction induced by adrenergic nerves, blood-borne substances, and local autacoids. Nitric oxide (NO) is a major endothelium-derived vasodilator, along with protacyclin. A third substance called endothelium-derived hyperpolarizing factors (EDHF) mediates vasodilatation in certain conduit arteries and in most resistance vessels. EDHF may be a cytochrome P-450 metabolite of arachidonic acid. NO acts mostly through an elevation of cyclic guanosine monophosphate in vascular smooth muscle, whereas prostacyclin stimulates adenylate cyclase. The mode of action of EDHF involves the activation of K+ channels. The multiplicity of the factors released by the endothelium, as well as the complexity of the interactions among these factors and those with other nonendothelial mediators, determine the extent of vasomotor control exerted locally by the endothelium.
Persistent Identifierhttp://hdl.handle.net/10722/171195
ISSN
2015 Impact Factor: 4.635
2015 SCImago Journal Rankings: 1.847
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorMombouli, JVen_US
dc.date.accessioned2012-10-30T06:12:38Z-
dc.date.available2012-10-30T06:12:38Z-
dc.date.issued1996en_US
dc.identifier.citationProgress In Cardiovascular Diseases, 1996, v. 39 n. 3, p. 229-238en_US
dc.identifier.issn0033-0620en_US
dc.identifier.urihttp://hdl.handle.net/10722/171195-
dc.description.abstractIn most blood vessels, the endothelium generates both vasodilator and growth-stabilizing mediators under normal physiological circumstances. The vasodilator influence of the endothelium modulates the vasoconstriction induced by adrenergic nerves, blood-borne substances, and local autacoids. Nitric oxide (NO) is a major endothelium-derived vasodilator, along with protacyclin. A third substance called endothelium-derived hyperpolarizing factors (EDHF) mediates vasodilatation in certain conduit arteries and in most resistance vessels. EDHF may be a cytochrome P-450 metabolite of arachidonic acid. NO acts mostly through an elevation of cyclic guanosine monophosphate in vascular smooth muscle, whereas prostacyclin stimulates adenylate cyclase. The mode of action of EDHF involves the activation of K+ channels. The multiplicity of the factors released by the endothelium, as well as the complexity of the interactions among these factors and those with other nonendothelial mediators, determine the extent of vasomotor control exerted locally by the endothelium.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/pcaden_US
dc.relation.ispartofProgress in Cardiovascular Diseasesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Factors - Physiologyen_US
dc.subject.meshEndothelium, Vascular - Cytology - Drug Effects - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshNitric Oxide - Physiologyen_US
dc.subject.meshReceptors, Endothelin - Drug Effects - Physiologyen_US
dc.subject.meshVasoconstrictor Agents - Pharmacologyen_US
dc.subject.meshVasodilator Agents - Pharmacologyen_US
dc.titleVascular endothelium: Vasoactive mediatorsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0033-0620(96)80003-Xen_US
dc.identifier.pmid8970575-
dc.identifier.scopuseid_2-s2.0-0030448012en_US
dc.identifier.volume39en_US
dc.identifier.issue3en_US
dc.identifier.spage229en_US
dc.identifier.epage238en_US
dc.identifier.isiWOS:A1996VY11800003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridMombouli, JV=7004285772en_US

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