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- Publisher Website: 10.1006/jmcc.1996.0215
- Scopus: eid_2-s2.0-0030296473
- PMID: 8938576
- WOS: WOS:A1996VT29100002
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Article: Endothelium-dependent responses in congestive heart failure
Title | Endothelium-dependent responses in congestive heart failure |
---|---|
Authors | |
Keywords | Congestive heart failure Endothelin Endothelium-derived contracting factors (EDCFs) Endothelium-derived relaxing factor (EDRF) Nitric oxide Shear stress |
Issue Date | 1996 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/yjmcc |
Citation | Journal Of Molecular And Cellular Cardiology, 1996, v. 28 n. 11, p. 2233-2240 How to Cite? |
Abstract | The endothelium is a major regulator of vascular tone because it releases vasoactive substances including: endothelium-derived relaxing factor (nitric oxide/EDRF), endothelium-derived hyperpolarizing factor (EDHF), prostacyclin, endothelin and endothelium-derived contracting factors (EDCFs). Three of these factors, nitric oxide, endothelin and a cyclooxygenase-dependent EDCF may play a role in congestive heart failure. A number of experimental and clinical studies describe impaired endothelium-dependent vasodilatations and increased plasma concentration of endothelin in congestive heart failure. The decrease of cardiac output, that results in a reduced shear stress on the endothelial cells and systemic endocrine compensatory mechanisms such as increased production of angiotensin-converting enzyme (leading to a greater breakdown of kinins) can modulate the release of nitric oxide and endothelin. It is unclear to which extent these modulations initiate, maintain, and/or compensate for the pathological process. |
Persistent Identifier | http://hdl.handle.net/10722/171193 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.639 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:12:37Z | - |
dc.date.available | 2012-10-30T06:12:37Z | - |
dc.date.issued | 1996 | en_US |
dc.identifier.citation | Journal Of Molecular And Cellular Cardiology, 1996, v. 28 n. 11, p. 2233-2240 | en_US |
dc.identifier.issn | 0022-2828 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171193 | - |
dc.description.abstract | The endothelium is a major regulator of vascular tone because it releases vasoactive substances including: endothelium-derived relaxing factor (nitric oxide/EDRF), endothelium-derived hyperpolarizing factor (EDHF), prostacyclin, endothelin and endothelium-derived contracting factors (EDCFs). Three of these factors, nitric oxide, endothelin and a cyclooxygenase-dependent EDCF may play a role in congestive heart failure. A number of experimental and clinical studies describe impaired endothelium-dependent vasodilatations and increased plasma concentration of endothelin in congestive heart failure. The decrease of cardiac output, that results in a reduced shear stress on the endothelial cells and systemic endocrine compensatory mechanisms such as increased production of angiotensin-converting enzyme (leading to a greater breakdown of kinins) can modulate the release of nitric oxide and endothelin. It is unclear to which extent these modulations initiate, maintain, and/or compensate for the pathological process. | en_US |
dc.language | eng | en_US |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/yjmcc | en_US |
dc.relation.ispartof | Journal of Molecular and Cellular Cardiology | en_US |
dc.subject | Congestive heart failure | - |
dc.subject | Endothelin | - |
dc.subject | Endothelium-derived contracting factors (EDCFs) | - |
dc.subject | Endothelium-derived relaxing factor (EDRF) | - |
dc.subject | Nitric oxide | - |
dc.subject | Shear stress | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Biological Factors - Physiology | en_US |
dc.subject.mesh | Endothelium, Vascular - Physiopathology | en_US |
dc.subject.mesh | Heart Failure - Physiopathology | en_US |
dc.subject.mesh | Humans | en_US |
dc.title | Endothelium-dependent responses in congestive heart failure | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1006/jmcc.1996.0215 | en_US |
dc.identifier.pmid | 8938576 | - |
dc.identifier.scopus | eid_2-s2.0-0030296473 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0030296473&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.spage | 2233 | en_US |
dc.identifier.epage | 2240 | en_US |
dc.identifier.isi | WOS:A1996VT29100002 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0022-2828 | - |