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Article: Endothelium-dependent responses in congestive heart failure

TitleEndothelium-dependent responses in congestive heart failure
Authors
Issue Date1996
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yjmcc
Citation
Journal Of Molecular And Cellular Cardiology, 1996, v. 28 n. 11, p. 2233-2240 How to Cite?
AbstractThe endothelium is a major regulator of vascular tone because it releases vasoactive substances including: endothelium-derived relaxing factor (nitric oxide/EDRF), endothelium-derived hyperpolarizing factor (EDHF), prostacyclin, endothelin and endothelium-derived contracting factors (EDCFs). Three of these factors, nitric oxide, endothelin and a cyclooxygenase-dependent EDCF may play a role in congestive heart failure. A number of experimental and clinical studies describe impaired endothelium-dependent vasodilatations and increased plasma concentration of endothelin in congestive heart failure. The decrease of cardiac output, that results in a reduced shear stress on the endothelial cells and systemic endocrine compensatory mechanisms such as increased production of angiotensin-converting enzyme (leading to a greater breakdown of kinins) can modulate the release of nitric oxide and endothelin. It is unclear to which extent these modulations initiate, maintain, and/or compensate for the pathological process.
Persistent Identifierhttp://hdl.handle.net/10722/171193
ISSN
2015 Impact Factor: 4.874
2015 SCImago Journal Rankings: 2.522
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:37Z-
dc.date.available2012-10-30T06:12:37Z-
dc.date.issued1996en_US
dc.identifier.citationJournal Of Molecular And Cellular Cardiology, 1996, v. 28 n. 11, p. 2233-2240en_US
dc.identifier.issn0022-2828en_US
dc.identifier.urihttp://hdl.handle.net/10722/171193-
dc.description.abstractThe endothelium is a major regulator of vascular tone because it releases vasoactive substances including: endothelium-derived relaxing factor (nitric oxide/EDRF), endothelium-derived hyperpolarizing factor (EDHF), prostacyclin, endothelin and endothelium-derived contracting factors (EDCFs). Three of these factors, nitric oxide, endothelin and a cyclooxygenase-dependent EDCF may play a role in congestive heart failure. A number of experimental and clinical studies describe impaired endothelium-dependent vasodilatations and increased plasma concentration of endothelin in congestive heart failure. The decrease of cardiac output, that results in a reduced shear stress on the endothelial cells and systemic endocrine compensatory mechanisms such as increased production of angiotensin-converting enzyme (leading to a greater breakdown of kinins) can modulate the release of nitric oxide and endothelin. It is unclear to which extent these modulations initiate, maintain, and/or compensate for the pathological process.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yjmccen_US
dc.relation.ispartofJournal of Molecular and Cellular Cardiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Factors - Physiologyen_US
dc.subject.meshEndothelium, Vascular - Physiopathologyen_US
dc.subject.meshHeart Failure - Physiopathologyen_US
dc.subject.meshHumansen_US
dc.titleEndothelium-dependent responses in congestive heart failureen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/jmcc.1996.0215en_US
dc.identifier.pmid8938576-
dc.identifier.scopuseid_2-s2.0-0030296473en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030296473&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume28en_US
dc.identifier.issue11en_US
dc.identifier.spage2233en_US
dc.identifier.epage2240en_US
dc.identifier.isiWOS:A1996VT29100002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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