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Article: Trandolapril plus verapamil inhibits the coronary vasospasm induced by hypoxia following ischemia-reperfusion injury in dogs

TitleTrandolapril plus verapamil inhibits the coronary vasospasm induced by hypoxia following ischemia-reperfusion injury in dogs
Authors
Issue Date1996
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vph
Citation
General Pharmacology, 1996, v. 27 n. 6, p. 1057-1059 How to Cite?
AbstractDogs were exposed to hypoxemia followed by a coronary angiogram at three different times: under control conditions, after ischemia-reperfusion injury, then 30 min later. In the study group, the dogs were treated with trandolapril (0.05 mg/kg) and verapamil (0.1 mg/kg) just prior to the final hypoxic challenge. Under control conditions, the left anterior descending coronary artery (LAD) dilated in response to hypoxia. Following ischemia-reperfusion injury, however, it constricted significantly in response. In the control group, repeat hypoxia 30 min later resulted in vasoconstriction of the LAD which was comparable to the preceding response. However, in the study group, treatment with trandolapril plus verapamil inhibited the vasoconstriction in response to repeat hypoxia.
Persistent Identifierhttp://hdl.handle.net/10722/171191
ISSN
2002 Impact Factor: 0.591
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, JJen_US
dc.contributor.authorBoulanger, CMen_US
dc.contributor.authorKirchengast, Men_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:36Z-
dc.date.available2012-10-30T06:12:36Z-
dc.date.issued1996en_US
dc.identifier.citationGeneral Pharmacology, 1996, v. 27 n. 6, p. 1057-1059en_US
dc.identifier.issn0306-3623en_US
dc.identifier.urihttp://hdl.handle.net/10722/171191-
dc.description.abstractDogs were exposed to hypoxemia followed by a coronary angiogram at three different times: under control conditions, after ischemia-reperfusion injury, then 30 min later. In the study group, the dogs were treated with trandolapril (0.05 mg/kg) and verapamil (0.1 mg/kg) just prior to the final hypoxic challenge. Under control conditions, the left anterior descending coronary artery (LAD) dilated in response to hypoxia. Following ischemia-reperfusion injury, however, it constricted significantly in response. In the control group, repeat hypoxia 30 min later resulted in vasoconstriction of the LAD which was comparable to the preceding response. However, in the study group, treatment with trandolapril plus verapamil inhibited the vasoconstriction in response to repeat hypoxia.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vphen_US
dc.relation.ispartofGeneral Pharmacologyen_US
dc.subject.meshAngiotensin-Converting Enzyme Inhibitors - Administration & Dosageen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnoxia - Complicationsen_US
dc.subject.meshCalcium Channel Blockers - Administration & Dosageen_US
dc.subject.meshCoronary Vasospasm - Etiology - Prevention & Controlen_US
dc.subject.meshDogsen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshIndoles - Administration & Dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardial Reperfusion Injury - Complicationsen_US
dc.subject.meshVerapamil - Administration & Dosageen_US
dc.titleTrandolapril plus verapamil inhibits the coronary vasospasm induced by hypoxia following ischemia-reperfusion injury in dogsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0306-3623(95)02129-9en_US
dc.identifier.pmid8909991-
dc.identifier.scopuseid_2-s2.0-0030250290en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030250290&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume27en_US
dc.identifier.issue6en_US
dc.identifier.spage1057en_US
dc.identifier.epage1059en_US
dc.identifier.isiWOS:A1996VK17500020-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, JJ=7601457545en_US
dc.identifier.scopusauthoridBoulanger, CM=7006599024en_US
dc.identifier.scopusauthoridKirchengast, M=7004242148en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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