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Article: Contributions of physical and chemical properties of mild irritants to gastric cytoprotection in rats

TitleContributions of physical and chemical properties of mild irritants to gastric cytoprotection in rats
Authors
Issue Date1995
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1995, v. 57 n. 1, p. PL13-PL18 How to Cite?
AbstractThe present study demonstrated the cytoprotective abilities of low concentrations of ethanol, NaCl and HCl, against the gastric mucosal damage caused by 100% ethanol, and the contributions of the physical and chemical properties of these mild irritants to their protective actions. The results have shown the differential protective effects of ethanol (10-40%), NaCl (2.5-12.5%) and HCl (0.15-0.45M), with the optimal cytoprotective concentrations being 20% ethanol, 5% NaCl and 0.3M HCl, respectively. Solutions of KCl and NaCl with similar osmolarity, and H 2SO 4 and HCl of similar acidity and osmolarity, all showed similar protective potentials as compared to the osmotic agent mannitol, which possessed a concentration- and tonicity-dependent protective action against 100% ethanol-induced mucosal damage. Same concentration of methanol, propan-2-ol and ethanol, having similar osmolarity with deionized water, exerted indifferent protective effects. It is therefore concluded that adaptive cytoprotection induced by low concentrations of NaCl and HCl could depend on their physical properties, while that of ethanol could act through its unique chemical property.
Persistent Identifierhttp://hdl.handle.net/10722/171163
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKo, JKSen_US
dc.contributor.authorCho, CHen_US
dc.contributor.authorLam, SKen_US
dc.contributor.authorKoo, MWLen_US
dc.contributor.authorChing, CKen_US
dc.date.accessioned2012-10-30T06:12:29Z-
dc.date.available2012-10-30T06:12:29Z-
dc.date.issued1995en_US
dc.identifier.citationLife Sciences, 1995, v. 57 n. 1, p. PL13-PL18en_US
dc.identifier.issn0024-3205en_US
dc.identifier.urihttp://hdl.handle.net/10722/171163-
dc.description.abstractThe present study demonstrated the cytoprotective abilities of low concentrations of ethanol, NaCl and HCl, against the gastric mucosal damage caused by 100% ethanol, and the contributions of the physical and chemical properties of these mild irritants to their protective actions. The results have shown the differential protective effects of ethanol (10-40%), NaCl (2.5-12.5%) and HCl (0.15-0.45M), with the optimal cytoprotective concentrations being 20% ethanol, 5% NaCl and 0.3M HCl, respectively. Solutions of KCl and NaCl with similar osmolarity, and H 2SO 4 and HCl of similar acidity and osmolarity, all showed similar protective potentials as compared to the osmotic agent mannitol, which possessed a concentration- and tonicity-dependent protective action against 100% ethanol-induced mucosal damage. Same concentration of methanol, propan-2-ol and ethanol, having similar osmolarity with deionized water, exerted indifferent protective effects. It is therefore concluded that adaptive cytoprotection induced by low concentrations of NaCl and HCl could depend on their physical properties, while that of ethanol could act through its unique chemical property.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_US
dc.relation.ispartofLife Sciencesen_US
dc.rightsLife Sciences. Copyright © Elsevier Inc.-
dc.subject.meshAnimalsen_US
dc.subject.meshChemistry, Physicalen_US
dc.subject.meshCryoprotective Agents - Chemistry - Therapeutic Use - Toxicityen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEthanol - Therapeutic Use - Toxicityen_US
dc.subject.meshGastric Mucosa - Drug Effectsen_US
dc.subject.meshHydrochloric Acid - Chemistry - Therapeutic Use - Toxicityen_US
dc.subject.meshIrritants - Chemistry - Therapeutic Use - Toxicityen_US
dc.subject.meshMaleen_US
dc.subject.meshMannitol - Therapeutic Useen_US
dc.subject.meshOsmolar Concentrationen_US
dc.subject.meshPhysicochemical Phenomenaen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSodium Chloride - Chemistry - Therapeutic Use - Toxicityen_US
dc.subject.meshStomach Diseases - Chemically Induced - Prevention & Controlen_US
dc.titleContributions of physical and chemical properties of mild irritants to gastric cytoprotection in ratsen_US
dc.typeArticleen_US
dc.identifier.emailKoo, MWL:wlkoo@hku.hken_US
dc.identifier.authorityKoo, MWL=rp00233en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0024-3205(95)00247-4en_US
dc.identifier.pmid7596213-
dc.identifier.scopuseid_2-s2.0-0029003687en_US
dc.identifier.hkuros8542-
dc.identifier.volume57en_US
dc.identifier.issue1en_US
dc.identifier.spagePL13en_US
dc.identifier.epagePL18en_US
dc.identifier.isiWOS:A1995RA96200011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKo, JKS=7402678571en_US
dc.identifier.scopusauthoridCho, CH=14067000400en_US
dc.identifier.scopusauthoridLam, SK=7402279473en_US
dc.identifier.scopusauthoridKoo, MWL=7004550899en_US
dc.identifier.scopusauthoridChing, CK=7102130825en_US

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