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Article: Magnesium sulfate and diphenylhydantoin relax canine middle cerebral artery contracted with the thromboxane-A2 analogue U46619 by different mechanisms: Implications for the management of eclampsia

TitleMagnesium sulfate and diphenylhydantoin relax canine middle cerebral artery contracted with the thromboxane-A2 analogue U46619 by different mechanisms: Implications for the management of eclampsia
Authors
KeywordsCerebral Vasospasm
Diphenylhydantoin
Magnesium Sulfate
Issue Date1994
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10641955.asp
Citation
Hypertension In Pregnancy, 1994, v. 13 n. 1, p. 51-60 How to Cite?
AbstractObjectives: To investigate the relaxant effect of MgSO4 and diphenylhydantoin on isolated canine middle cerebral artery (MCA) rings contracted with the thromboxane-A2 analogue U46619. Methods: Canine MCA rings, with and without endothelium, were suspended in organ chambers for isometric tension recording, they were contracted with U46619 in the presence of indomethacin, with and without nitro-L-arginine (NLA). Cumulative dose-response curves were performed using MgSO4 (10-8 M to 10-2 M) and diphenylhydantoin (10-9 M to 10-3 M). Main Outcome Measures: Tension at each concentration of the study drug expressed as a percentage of the maximum tension developed with U46619; area under the concentration response curve. Results: Both MgSO4 and diphenylhydantoin relaxed the MCA rings irrespective of the presence of endothelium. Diphenylhydantoin caused an endothelium-dependent relaxation at concentrations above 3x10-5 M, unaffected by NLA. Conclusions: MgSO4 relaxes canine MCA by a direct smooth muscle effect independent of the endothelium. Diphenylhydantoin causes an endothelium-dependent relaxation of canine MCA at concentrations above 3x10-5 M, unrelated to nitric oxide. MgSO4 and diphenylhydantoin may both help to prevent seizures in patients with eclampsia by reducing the potential for cerebral vasospasm.
Persistent Identifierhttp://hdl.handle.net/10722/171145
ISSN
2015 Impact Factor: 1.211
2015 SCImago Journal Rankings: 0.578

 

DC FieldValueLanguage
dc.contributor.authorBelfort, MAen_US
dc.contributor.authorSaade, GRen_US
dc.contributor.authorMoise Jr, KJen_US
dc.contributor.authorKirshon, Ben_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:23Z-
dc.date.available2012-10-30T06:12:23Z-
dc.date.issued1994en_US
dc.identifier.citationHypertension In Pregnancy, 1994, v. 13 n. 1, p. 51-60en_US
dc.identifier.issn1064-1955en_US
dc.identifier.urihttp://hdl.handle.net/10722/171145-
dc.description.abstractObjectives: To investigate the relaxant effect of MgSO4 and diphenylhydantoin on isolated canine middle cerebral artery (MCA) rings contracted with the thromboxane-A2 analogue U46619. Methods: Canine MCA rings, with and without endothelium, were suspended in organ chambers for isometric tension recording, they were contracted with U46619 in the presence of indomethacin, with and without nitro-L-arginine (NLA). Cumulative dose-response curves were performed using MgSO4 (10-8 M to 10-2 M) and diphenylhydantoin (10-9 M to 10-3 M). Main Outcome Measures: Tension at each concentration of the study drug expressed as a percentage of the maximum tension developed with U46619; area under the concentration response curve. Results: Both MgSO4 and diphenylhydantoin relaxed the MCA rings irrespective of the presence of endothelium. Diphenylhydantoin caused an endothelium-dependent relaxation at concentrations above 3x10-5 M, unaffected by NLA. Conclusions: MgSO4 relaxes canine MCA by a direct smooth muscle effect independent of the endothelium. Diphenylhydantoin causes an endothelium-dependent relaxation of canine MCA at concentrations above 3x10-5 M, unrelated to nitric oxide. MgSO4 and diphenylhydantoin may both help to prevent seizures in patients with eclampsia by reducing the potential for cerebral vasospasm.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10641955.aspen_US
dc.relation.ispartofHypertension in Pregnancyen_US
dc.subjectCerebral Vasospasmen_US
dc.subjectDiphenylhydantoinen_US
dc.subjectMagnesium Sulfateen_US
dc.titleMagnesium sulfate and diphenylhydantoin relax canine middle cerebral artery contracted with the thromboxane-A2 analogue U46619 by different mechanisms: Implications for the management of eclampsiaen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0028350849en_US
dc.identifier.volume13en_US
dc.identifier.issue1en_US
dc.identifier.spage51en_US
dc.identifier.epage60en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridBelfort, MA=7102893402en_US
dc.identifier.scopusauthoridSaade, GR=7006942866en_US
dc.identifier.scopusauthoridMoise Jr, KJ=7005901536en_US
dc.identifier.scopusauthoridKirshon, B=7003767989en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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