File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Epithelium acts as a modulator and a diffusion barrier in the responses of canine airway smooth muscle

TitleEpithelium acts as a modulator and a diffusion barrier in the responses of canine airway smooth muscle
Authors
Issue Date1994
Citation
Journal Of Applied Physiology, 1994, v. 76 n. 5, p. 1843-1847 How to Cite?
AbstractThe present study was designed to determine the role of the respiratory epithelium as a diffusion barrier and a modulator of the responsiveness of airway smooth muscle to bronchoactive agents. Segments of canine bronchi, with or without epithelium, were suspended in organ chambers and perfused intraluminally. The isometric tension was recorded. Acetylcholine, given intraluminally, induced significantly smaller contractions in bronchi with than in bronchi without epithelium. When this agonist was given extraluminally, no difference in contractions was noted between the tissues. In the presence of acetylcholine and phentolamine, norepinephrine, given either intra- or extraluminally, induced significantly larger relaxations in bronchi with than in bronchi without epithelium. High potassium given intraluminally induced contractions only in bronchi without epithelium; however, in the presence of ouabain, both tissues contracted similarly. When high potassium was given extraluminally, no difference in contraction between tissues with and without epithelium was noted. When [3H]acetylcholine and [3H]norepinephrine were perfused intraluminally, the accumulation of 3H radioactivity in the extraluminal solutions was significantly less in bronchi with than in bronchi without epithelium. These observations suggest that the epithelium acts as both a diffusion barrier and a modulator of the responses of canine airways to bronchoactive agents.
Persistent Identifierhttp://hdl.handle.net/10722/171144
ISSN
2015 Impact Factor: 3.004
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGao, Yen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:23Z-
dc.date.available2012-10-30T06:12:23Z-
dc.date.issued1994en_US
dc.identifier.citationJournal Of Applied Physiology, 1994, v. 76 n. 5, p. 1843-1847en_US
dc.identifier.issn8750-7587en_US
dc.identifier.urihttp://hdl.handle.net/10722/171144-
dc.description.abstractThe present study was designed to determine the role of the respiratory epithelium as a diffusion barrier and a modulator of the responsiveness of airway smooth muscle to bronchoactive agents. Segments of canine bronchi, with or without epithelium, were suspended in organ chambers and perfused intraluminally. The isometric tension was recorded. Acetylcholine, given intraluminally, induced significantly smaller contractions in bronchi with than in bronchi without epithelium. When this agonist was given extraluminally, no difference in contractions was noted between the tissues. In the presence of acetylcholine and phentolamine, norepinephrine, given either intra- or extraluminally, induced significantly larger relaxations in bronchi with than in bronchi without epithelium. High potassium given intraluminally induced contractions only in bronchi without epithelium; however, in the presence of ouabain, both tissues contracted similarly. When high potassium was given extraluminally, no difference in contraction between tissues with and without epithelium was noted. When [3H]acetylcholine and [3H]norepinephrine were perfused intraluminally, the accumulation of 3H radioactivity in the extraluminal solutions was significantly less in bronchi with than in bronchi without epithelium. These observations suggest that the epithelium acts as both a diffusion barrier and a modulator of the responses of canine airways to bronchoactive agents.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Applied Physiologyen_US
dc.subject.meshAcetylcholine - Pharmacokinetics - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBronchi - Metabolismen_US
dc.subject.meshBronchoconstrictor Agents - Pharmacologyen_US
dc.subject.meshBronchodilator Agents - Pharmacologyen_US
dc.subject.meshDiffusionen_US
dc.subject.meshDogsen_US
dc.subject.meshEpithelium - Metabolism - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshIsometric Contraction - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle, Smooth - Drug Effects - Metabolism - Physiologyen_US
dc.subject.meshNorepinephrine - Pharmacokinetics - Pharmacologyen_US
dc.subject.meshPotassium - Pharmacologyen_US
dc.subject.meshRespiratory Physiological Phenomenaen_US
dc.subject.meshRespiratory System - Drug Effects - Metabolismen_US
dc.titleEpithelium acts as a modulator and a diffusion barrier in the responses of canine airway smooth muscleen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8063639-
dc.identifier.scopuseid_2-s2.0-0028340432en_US
dc.identifier.volume76en_US
dc.identifier.issue5en_US
dc.identifier.spage1843en_US
dc.identifier.epage1847en_US
dc.identifier.isiWOS:A1994NL97000002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGao, Y=7404706442en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats