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- Scopus: eid_2-s2.0-0028340432
- PMID: 8063639
- WOS: WOS:A1994NL97000002
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Article: Epithelium acts as a modulator and a diffusion barrier in the responses of canine airway smooth muscle
Title | Epithelium acts as a modulator and a diffusion barrier in the responses of canine airway smooth muscle |
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Authors | |
Keywords | acetylcholine norepinephrine potassium |
Issue Date | 1994 |
Citation | Journal Of Applied Physiology, 1994, v. 76 n. 5, p. 1843-1847 How to Cite? |
Abstract | The present study was designed to determine the role of the respiratory epithelium as a diffusion barrier and a modulator of the responsiveness of airway smooth muscle to bronchoactive agents. Segments of canine bronchi, with or without epithelium, were suspended in organ chambers and perfused intraluminally. The isometric tension was recorded. Acetylcholine, given intraluminally, induced significantly smaller contractions in bronchi with than in bronchi without epithelium. When this agonist was given extraluminally, no difference in contractions was noted between the tissues. In the presence of acetylcholine and phentolamine, norepinephrine, given either intra- or extraluminally, induced significantly larger relaxations in bronchi with than in bronchi without epithelium. High potassium given intraluminally induced contractions only in bronchi without epithelium; however, in the presence of ouabain, both tissues contracted similarly. When high potassium was given extraluminally, no difference in contraction between tissues with and without epithelium was noted. When [3H]acetylcholine and [3H]norepinephrine were perfused intraluminally, the accumulation of 3H radioactivity in the extraluminal solutions was significantly less in bronchi with than in bronchi without epithelium. These observations suggest that the epithelium acts as both a diffusion barrier and a modulator of the responses of canine airways to bronchoactive agents. |
Persistent Identifier | http://hdl.handle.net/10722/171144 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 1.042 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Gao, Y | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:12:23Z | - |
dc.date.available | 2012-10-30T06:12:23Z | - |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | Journal Of Applied Physiology, 1994, v. 76 n. 5, p. 1843-1847 | en_US |
dc.identifier.issn | 8750-7587 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171144 | - |
dc.description.abstract | The present study was designed to determine the role of the respiratory epithelium as a diffusion barrier and a modulator of the responsiveness of airway smooth muscle to bronchoactive agents. Segments of canine bronchi, with or without epithelium, were suspended in organ chambers and perfused intraluminally. The isometric tension was recorded. Acetylcholine, given intraluminally, induced significantly smaller contractions in bronchi with than in bronchi without epithelium. When this agonist was given extraluminally, no difference in contractions was noted between the tissues. In the presence of acetylcholine and phentolamine, norepinephrine, given either intra- or extraluminally, induced significantly larger relaxations in bronchi with than in bronchi without epithelium. High potassium given intraluminally induced contractions only in bronchi without epithelium; however, in the presence of ouabain, both tissues contracted similarly. When high potassium was given extraluminally, no difference in contraction between tissues with and without epithelium was noted. When [3H]acetylcholine and [3H]norepinephrine were perfused intraluminally, the accumulation of 3H radioactivity in the extraluminal solutions was significantly less in bronchi with than in bronchi without epithelium. These observations suggest that the epithelium acts as both a diffusion barrier and a modulator of the responses of canine airways to bronchoactive agents. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Journal of Applied Physiology | en_US |
dc.subject | acetylcholine | - |
dc.subject | norepinephrine | - |
dc.subject | potassium | - |
dc.subject.mesh | Acetylcholine - Pharmacokinetics - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Bronchi - Metabolism | en_US |
dc.subject.mesh | Bronchoconstrictor Agents - Pharmacology | en_US |
dc.subject.mesh | Bronchodilator Agents - Pharmacology | en_US |
dc.subject.mesh | Diffusion | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Epithelium - Metabolism - Physiology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Isometric Contraction - Drug Effects | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Muscle, Smooth - Drug Effects - Metabolism - Physiology | en_US |
dc.subject.mesh | Norepinephrine - Pharmacokinetics - Pharmacology | en_US |
dc.subject.mesh | Potassium - Pharmacology | en_US |
dc.subject.mesh | Respiratory Physiological Phenomena | en_US |
dc.subject.mesh | Respiratory System - Drug Effects - Metabolism | en_US |
dc.title | Epithelium acts as a modulator and a diffusion barrier in the responses of canine airway smooth muscle | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 8063639 | - |
dc.identifier.scopus | eid_2-s2.0-0028340432 | en_US |
dc.identifier.volume | 76 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 1843 | en_US |
dc.identifier.epage | 1847 | en_US |
dc.identifier.isi | WOS:A1994NL97000002 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Gao, Y=7404706442 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 1522-1601 | - |