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Article: Modulatory role of 5-HT3 receptors in gastric function and ethanol-induced mucosal damage in rat stomachs

TitleModulatory role of 5-HT3 receptors in gastric function and ethanol-induced mucosal damage in rat stomachs
Authors
Issue Date1994
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/PHA
Citation
Pharmacology, 1994, v. 49 n. 3, p. 137-143 How to Cite?
AbstractThe involvement of 5-hydroxytryptamine (5-HT) in gastric function and mucosal damage has been defined. 5-HT also potentiates lesion formation in animals. The current study investigated further whether these actions are mediated through 5-HT3 receptors in rats. Ondansetron, a 5-HT3 receptor antagonist, was given subcutaneously, 2 or 4 mg/kg, 30 min before the gastric parameters were measured. The higher dose of ondansetron, 4 mg/kg, significantly increased gastric mucosal blood flow (GMBF) and also basal acid and Na+ secretion. However, it did not affect pepsin output. 5-HT time dependently reduced GMBF and pepsin secretion, but not that of acid and Na+. These actions were not altered by ondansetron pretreatment. The drug, however, dose dependently reduced ethanol-induced gastric mucosal lesions in the 5-HT-treated animals. These findings indicate that 5-HT3 receptors regulate not only basal GMBF, but also acid and Na+ secretion in stomachs. However, the depressive action of 5-HT on GMBF and pepsin secretion is most likely not mediated through 5-HT3 receptors. Ondansetron also modulates the toxicities of ethanol in the stomach and this action is likely to be mediated through the preservation of GMBF.
Persistent Identifierhttp://hdl.handle.net/10722/171119
ISSN
2015 Impact Factor: 1.533
2015 SCImago Journal Rankings: 0.645
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCho, CHen_US
dc.contributor.authorKoo, MWLen_US
dc.contributor.authorKo, JKSen_US
dc.date.accessioned2012-10-30T06:12:16Z-
dc.date.available2012-10-30T06:12:16Z-
dc.date.issued1994en_US
dc.identifier.citationPharmacology, 1994, v. 49 n. 3, p. 137-143en_US
dc.identifier.issn0031-7012en_US
dc.identifier.urihttp://hdl.handle.net/10722/171119-
dc.description.abstractThe involvement of 5-hydroxytryptamine (5-HT) in gastric function and mucosal damage has been defined. 5-HT also potentiates lesion formation in animals. The current study investigated further whether these actions are mediated through 5-HT3 receptors in rats. Ondansetron, a 5-HT3 receptor antagonist, was given subcutaneously, 2 or 4 mg/kg, 30 min before the gastric parameters were measured. The higher dose of ondansetron, 4 mg/kg, significantly increased gastric mucosal blood flow (GMBF) and also basal acid and Na+ secretion. However, it did not affect pepsin output. 5-HT time dependently reduced GMBF and pepsin secretion, but not that of acid and Na+. These actions were not altered by ondansetron pretreatment. The drug, however, dose dependently reduced ethanol-induced gastric mucosal lesions in the 5-HT-treated animals. These findings indicate that 5-HT3 receptors regulate not only basal GMBF, but also acid and Na+ secretion in stomachs. However, the depressive action of 5-HT on GMBF and pepsin secretion is most likely not mediated through 5-HT3 receptors. Ondansetron also modulates the toxicities of ethanol in the stomach and this action is likely to be mediated through the preservation of GMBF.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/PHAen_US
dc.relation.ispartofPharmacologyen_US
dc.rightsPharmacology. Copyright © S Karger AG.-
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Flow Velocity - Drug Effectsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEthanol - Toxicityen_US
dc.subject.meshGastric Acid - Secretionen_US
dc.subject.meshGastric Mucosa - Blood Supply - Drug Effects - Physiopathologyen_US
dc.subject.meshInjections, Subcutaneousen_US
dc.subject.meshMaleen_US
dc.subject.meshOndansetron - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReceptors, Serotonin - Physiologyen_US
dc.subject.meshRegional Blood Flow - Drug Effectsen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.subject.meshStomach Ulcer - Chemically Induced - Prevention & Controlen_US
dc.titleModulatory role of 5-HT3 receptors in gastric function and ethanol-induced mucosal damage in rat stomachsen_US
dc.typeArticleen_US
dc.identifier.emailKoo, MWL:wlkoo@hku.hken_US
dc.identifier.authorityKoo, MWL=rp00233en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000139227-
dc.identifier.pmid7972327-
dc.identifier.scopuseid_2-s2.0-0027965666en_US
dc.identifier.hkuros3577-
dc.identifier.volume49en_US
dc.identifier.issue3en_US
dc.identifier.spage137en_US
dc.identifier.epage143en_US
dc.identifier.isiWOS:A1994PB94600001-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridCho, CH=7403100461en_US
dc.identifier.scopusauthoridKoo, MWL=7004550899en_US
dc.identifier.scopusauthoridKo, JKS=7402678571en_US

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