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Article: Role of gastric glandular mucosal energy metabolism in cold-restraint gastric lesion formation

TitleRole of gastric glandular mucosal energy metabolism in cold-restraint gastric lesion formation
Authors
Issue Date1993
Citation
Archives Internationales De Pharmacodynamie Et De Therapie, 1993, v. 326, p. 84-94 How to Cite?
AbstractThe effects of cold and restraint and of some of the antiulcer drugs on adenosine nucleotide content in the gastric glandular mucosa were examined. A bioluminescence technique was used to measure the amount of ATP and its metabolites in gastric mucosal tissue. Cold-restraint produced gastric lesions and increased the gastric mucosal ATP. Verapamil pretreatment attenuated these lesions and further intensified the ATP increase in a dose- related manner. The ATP/ADP ratio and the Atkinson index were also elevated. Calcium gluconate produced similar effects. Atropine or EGTA pretreatment protected or worsened the gastric lesion, respectively, but did not have any influence on the changes in mucosal energy metabolism. Ranitidine pretreatment lessened the lesion formation but had no influence on the nucleotide content. These findings indicate that the metabolic rate of the gastric mucosa is suppressed during cold-restraint conditions; this depression is probably due to hypothermia and reduction of mucosal metabolism. The lesion-protecting mechanisms of the drugs do not seem to be mediated through their effects on mucosal energy metabolism. The oxygen- and ATP-sparing effects of verapamil may contribute partly to its gastro- protective effect.
Persistent Identifierhttp://hdl.handle.net/10722/171116
ISSN
1998 Impact Factor: 0.72
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKoo, MWLen_US
dc.contributor.authorCho, CHen_US
dc.contributor.authorOgle, CWen_US
dc.date.accessioned2012-10-30T06:12:15Z-
dc.date.available2012-10-30T06:12:15Z-
dc.date.issued1993en_US
dc.identifier.citationArchives Internationales De Pharmacodynamie Et De Therapie, 1993, v. 326, p. 84-94en_US
dc.identifier.issn0003-9780en_US
dc.identifier.urihttp://hdl.handle.net/10722/171116-
dc.description.abstractThe effects of cold and restraint and of some of the antiulcer drugs on adenosine nucleotide content in the gastric glandular mucosa were examined. A bioluminescence technique was used to measure the amount of ATP and its metabolites in gastric mucosal tissue. Cold-restraint produced gastric lesions and increased the gastric mucosal ATP. Verapamil pretreatment attenuated these lesions and further intensified the ATP increase in a dose- related manner. The ATP/ADP ratio and the Atkinson index were also elevated. Calcium gluconate produced similar effects. Atropine or EGTA pretreatment protected or worsened the gastric lesion, respectively, but did not have any influence on the changes in mucosal energy metabolism. Ranitidine pretreatment lessened the lesion formation but had no influence on the nucleotide content. These findings indicate that the metabolic rate of the gastric mucosa is suppressed during cold-restraint conditions; this depression is probably due to hypothermia and reduction of mucosal metabolism. The lesion-protecting mechanisms of the drugs do not seem to be mediated through their effects on mucosal energy metabolism. The oxygen- and ATP-sparing effects of verapamil may contribute partly to its gastro- protective effect.en_US
dc.languageengen_US
dc.relation.ispartofArchives Internationales de Pharmacodynamie et de Therapieen_US
dc.subject.meshAdenosine Diphosphate - Analysisen_US
dc.subject.meshAdenosine Monophosphate - Analysisen_US
dc.subject.meshAdenosine Triphosphate - Analysisen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAtropine - Pharmacologyen_US
dc.subject.meshCalcium Gluconate - Pharmacologyen_US
dc.subject.meshCold Temperature - Adverse Effectsen_US
dc.subject.meshCyclic Amp - Analysisen_US
dc.subject.meshEgtazic Acid - Pharmacologyen_US
dc.subject.meshEnergy Metabolism - Drug Effects - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastric Mucosa - Drug Effects - Metabolismen_US
dc.subject.meshRanitidine - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshStomach Ulcer - Etiology - Metabolismen_US
dc.subject.meshVerapamil - Pharmacologyen_US
dc.titleRole of gastric glandular mucosal energy metabolism in cold-restraint gastric lesion formationen_US
dc.typeArticleen_US
dc.identifier.emailKoo, MWL:wlkoo@hku.hken_US
dc.identifier.authorityKoo, MWL=rp00233en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8185416-
dc.identifier.scopuseid_2-s2.0-0027858977en_US
dc.identifier.volume326en_US
dc.identifier.spage84en_US
dc.identifier.epage94en_US
dc.identifier.isiWOS:A1993MY11100008-
dc.identifier.scopusauthoridKoo, MWL=7004550899en_US
dc.identifier.scopusauthoridCho, CH=7403100461en_US
dc.identifier.scopusauthoridOgle, CW=7103150233en_US

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