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Article: Growth factor regulation of interleukin-1β-induced nitric oxide synthase and GTP:cyclohydrolase expression in cultured smooth muscle cells

TitleGrowth factor regulation of interleukin-1β-induced nitric oxide synthase and GTP:cyclohydrolase expression in cultured smooth muscle cells
Authors
Issue Date1993
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 1993, v. 196 n. 3, p. 1261-1266 How to Cite?
AbstractInduction of NO synthase expression by interleukin-1β in cultured vascular smooth muscle cells from rat aortas was accompanied by simultaneous induction of GTP:cyclohydrolase I. This enzyme regulates the de novo synthesis pathway for tetrahydrobiopterin, an essential cofactor for the catalytic conversion of L-arginine to L-citrulline and NO by inducible NO synthase. Inhibition of GTP:cyclohydrolase attenuated NO production by interleukin-1β-stimulated smooth muscle cells. Peptide growth factors such as fibroblast growth factor, platelet-derived growth factor and transforming growth factorβ1 and the protease thrombin have been shown to modulate the production NO by cytokine-treated smooth muscle cells. These peptide agonists also regulated the induction of NO synthase and GTP:cyclohydrolase mRNA expression.
Persistent Identifierhttp://hdl.handle.net/10722/171110
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorScottBurden, Ten_US
dc.contributor.authorElizondo, Een_US
dc.contributor.authorGe, Ten_US
dc.contributor.authorBoulanger, CMen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:14Z-
dc.date.available2012-10-30T06:12:14Z-
dc.date.issued1993en_US
dc.identifier.citationBiochemical And Biophysical Research Communications, 1993, v. 196 n. 3, p. 1261-1266en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/171110-
dc.description.abstractInduction of NO synthase expression by interleukin-1β in cultured vascular smooth muscle cells from rat aortas was accompanied by simultaneous induction of GTP:cyclohydrolase I. This enzyme regulates the de novo synthesis pathway for tetrahydrobiopterin, an essential cofactor for the catalytic conversion of L-arginine to L-citrulline and NO by inducible NO synthase. Inhibition of GTP:cyclohydrolase attenuated NO production by interleukin-1β-stimulated smooth muscle cells. Peptide growth factors such as fibroblast growth factor, platelet-derived growth factor and transforming growth factorβ1 and the protease thrombin have been shown to modulate the production NO by cytokine-treated smooth muscle cells. These peptide agonists also regulated the induction of NO synthase and GTP:cyclohydrolase mRNA expression.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.subject.meshAmino Acid Oxidoreductases - Biosynthesisen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAorta - Drug Effects - Enzymologyen_US
dc.subject.meshBlotting, Northernen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshGtp Cyclohydrolase - Biosynthesisen_US
dc.subject.meshGene Expression - Drug Effectsen_US
dc.subject.meshGrowth Substances - Pharmacologyen_US
dc.subject.meshInterleukin-1 - Pharmacologyen_US
dc.subject.meshKineticsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Enzymologyen_US
dc.subject.meshNitric Oxide Synthaseen_US
dc.subject.meshPlatelet-Derived Growth Factor - Pharmacologyen_US
dc.subject.meshRna, Messenger - Biosynthesisen_US
dc.subject.meshRatsen_US
dc.subject.meshTransforming Growth Factor Beta - Pharmacologyen_US
dc.titleGrowth factor regulation of interleukin-1β-induced nitric oxide synthase and GTP:cyclohydrolase expression in cultured smooth muscle cellsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/bbrc.1993.2388en_US
dc.identifier.pmid7504472-
dc.identifier.scopuseid_2-s2.0-0027490483en_US
dc.identifier.volume196en_US
dc.identifier.issue3en_US
dc.identifier.spage1261en_US
dc.identifier.epage1266en_US
dc.identifier.isiWOS:A1993MG31000036-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridScottBurden, T=7004306459en_US
dc.identifier.scopusauthoridElizondo, E=6603922947en_US
dc.identifier.scopusauthoridGe, T=7003328740en_US
dc.identifier.scopusauthoridBoulanger, CM=7006599024en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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