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Article: Effects of selenium supplement on the de novo biosynthesis of glycerolipids in the isolated rat heart

TitleEffects of selenium supplement on the de novo biosynthesis of glycerolipids in the isolated rat heart
Authors
Issue Date1993
Citation
Biochimica Et Biophysica Acta - Lipids And Lipid Metabolism, 1993, v. 1170 n. 3, p. 307-313 How to Cite?
AbstractThe effect of selenium supplement on glycerolipid biosynthesis in the isolated rat heart was investigated. Selenium was administered to the rat by intraperitoneal injection of 4.33 μmol/kg per day for 3 consecutive days. Animals administered with an equal volume of saline were used as controls. Hearts from both animal groups were perfused in Krebs-Henseleit buffer containing labelled glycerol. Subsequent to perfusion, the radioactivity associated with each glycerolipid group was determined. Selenium supplement caused elevations in the labelling of phosphatidic acid and phosphatidylcholine but not in other phospholipids, diacylglycerol or triacylglycerol. The mechanisms for the enhancement of labelling into phosphatidic acid and phosphatidylcholine were examined. The activity of the enzymes responsible for the synthesis of phosphatidic acid in the rat heart was not changed by selenium supplement. However, a 51% increase in the acyl-CoA level was detected which might account for the elevated labelling of phosphatidic acid in the selenium supplemented animal. The 2-fold increase in the activity of CDPcholine:diacylglycerol cholinephosphotransferase might also account for the increase in the labelling of phosphatidylcholine in the heart of the selenium-supplemented rat. It is clear from this study that selenium plays a regulatory role in the control of cellular lipid metabolism.
Persistent Identifierhttp://hdl.handle.net/10722/171106
ISSN
2000 Impact Factor: 2.973
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, SYen_US
dc.contributor.authorTardi, PGen_US
dc.contributor.authorChoy, PCen_US
dc.contributor.authorMan, RYKen_US
dc.date.accessioned2012-10-30T06:12:12Z-
dc.date.available2012-10-30T06:12:12Z-
dc.date.issued1993en_US
dc.identifier.citationBiochimica Et Biophysica Acta - Lipids And Lipid Metabolism, 1993, v. 1170 n. 3, p. 307-313en_US
dc.identifier.issn0005-2760en_US
dc.identifier.urihttp://hdl.handle.net/10722/171106-
dc.description.abstractThe effect of selenium supplement on glycerolipid biosynthesis in the isolated rat heart was investigated. Selenium was administered to the rat by intraperitoneal injection of 4.33 μmol/kg per day for 3 consecutive days. Animals administered with an equal volume of saline were used as controls. Hearts from both animal groups were perfused in Krebs-Henseleit buffer containing labelled glycerol. Subsequent to perfusion, the radioactivity associated with each glycerolipid group was determined. Selenium supplement caused elevations in the labelling of phosphatidic acid and phosphatidylcholine but not in other phospholipids, diacylglycerol or triacylglycerol. The mechanisms for the enhancement of labelling into phosphatidic acid and phosphatidylcholine were examined. The activity of the enzymes responsible for the synthesis of phosphatidic acid in the rat heart was not changed by selenium supplement. However, a 51% increase in the acyl-CoA level was detected which might account for the elevated labelling of phosphatidic acid in the selenium supplemented animal. The 2-fold increase in the activity of CDPcholine:diacylglycerol cholinephosphotransferase might also account for the increase in the labelling of phosphatidylcholine in the heart of the selenium-supplemented rat. It is clear from this study that selenium plays a regulatory role in the control of cellular lipid metabolism.en_US
dc.languageengen_US
dc.relation.ispartofBiochimica et Biophysica Acta - Lipids and Lipid Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshGlutathione Peroxidase - Metabolismen_US
dc.subject.meshGlycerides - Biosynthesisen_US
dc.subject.meshGlycerol - Metabolismen_US
dc.subject.meshHeart - Drug Effectsen_US
dc.subject.meshLiver - Drug Effects - Metabolismen_US
dc.subject.meshMyocardium - Metabolismen_US
dc.subject.meshPhosphatidic Acids - Biosynthesisen_US
dc.subject.meshPhosphatidylcholines - Biosynthesisen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSelenium - Blood - Metabolism - Pharmacologyen_US
dc.subject.meshTritiumen_US
dc.titleEffects of selenium supplement on the de novo biosynthesis of glycerolipids in the isolated rat hearten_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0005-2760(93)90015-2en_US
dc.identifier.pmid8218350-
dc.identifier.scopuseid_2-s2.0-0027444862en_US
dc.identifier.volume1170en_US
dc.identifier.issue3en_US
dc.identifier.spage307en_US
dc.identifier.epage313en_US
dc.identifier.isiWOS:A1993MF89000013-
dc.identifier.scopusauthoridLiu, SY=24822482600en_US
dc.identifier.scopusauthoridTardi, PG=36805754700en_US
dc.identifier.scopusauthoridChoy, PC=7006633002en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US

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