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Article: Alpha-adrenergic receptor responsiveness in vascular smooth muscle of canine bone

TitleAlpha-adrenergic receptor responsiveness in vascular smooth muscle of canine bone
Authors
Issue Date1993
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.corronline.com/
Citation
Clinical Orthopaedics And Related Research, 1993 n. 287, p. 286-291 How to Cite?
AbstractIn an ex vivo canine tibial preparation, an alpha-1-adrenergic antagonist (prazosin, 212 ng · ml-1 · minute-1) markedly attenuated the effect of high intraluminal doses (greater than 0.5 mg) of norepinephrine but was less effective at lower doses. An alpha-2-adrenergic antagonist (rauwolscine, 198 ng/ml/minute) was more effective than prazosin in blocking the vascular smooth muscle contraction evoked by low doses of norepinephrine (greater than 0.125 mg). Cirazoline, an alpha-1-adrenergic agonist, had a potent contractile effect on smooth muscle at high concentrations (5 x 10-6 M), whereas the alpha-2-adrenergic agonist UK14304 was more effective at low concentrations (1 x 10-7 M). Thus, in the vascular smooth muscle of canine tibia there is a mixed population of postjunctional alpha-1 and alpha-2- adrenergic receptors that exhibits a dose-dependent responsiveness. Adrenergic receptor mechanisms may contribute to alterations in bone blood flow. This may be relevant to impaired reperfusion after microvascular bone transfer. Furthermore, adrenergic receptor mechanisms may help explain variations in bone blood flow related to systemic, regional humoral, or metabolic factors.
Persistent Identifierhttp://hdl.handle.net/10722/171102
ISSN
2015 Impact Factor: 3.127
2015 SCImago Journal Rankings: 2.094
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYe, Zen_US
dc.contributor.authorWood, MBen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:11Z-
dc.date.available2012-10-30T06:12:11Z-
dc.date.issued1993en_US
dc.identifier.citationClinical Orthopaedics And Related Research, 1993 n. 287, p. 286-291en_US
dc.identifier.issn0009-921Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/171102-
dc.description.abstractIn an ex vivo canine tibial preparation, an alpha-1-adrenergic antagonist (prazosin, 212 ng · ml-1 · minute-1) markedly attenuated the effect of high intraluminal doses (greater than 0.5 mg) of norepinephrine but was less effective at lower doses. An alpha-2-adrenergic antagonist (rauwolscine, 198 ng/ml/minute) was more effective than prazosin in blocking the vascular smooth muscle contraction evoked by low doses of norepinephrine (greater than 0.125 mg). Cirazoline, an alpha-1-adrenergic agonist, had a potent contractile effect on smooth muscle at high concentrations (5 x 10-6 M), whereas the alpha-2-adrenergic agonist UK14304 was more effective at low concentrations (1 x 10-7 M). Thus, in the vascular smooth muscle of canine tibia there is a mixed population of postjunctional alpha-1 and alpha-2- adrenergic receptors that exhibits a dose-dependent responsiveness. Adrenergic receptor mechanisms may contribute to alterations in bone blood flow. This may be relevant to impaired reperfusion after microvascular bone transfer. Furthermore, adrenergic receptor mechanisms may help explain variations in bone blood flow related to systemic, regional humoral, or metabolic factors.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.corronline.com/en_US
dc.relation.ispartofClinical Orthopaedics and Related Researchen_US
dc.subject.meshAdrenergic Alpha-Agonists - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDogsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Chemistry - Drug Effectsen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPrazosin - Pharmacologyen_US
dc.subject.meshQuinoxalines - Pharmacologyen_US
dc.subject.meshReceptors, Adrenergic, Alpha - Analysis - Drug Effectsen_US
dc.subject.meshRegional Blood Flowen_US
dc.subject.meshTibia - Blood Supplyen_US
dc.subject.meshYohimbine - Pharmacologyen_US
dc.titleAlpha-adrenergic receptor responsiveness in vascular smooth muscle of canine boneen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8095442-
dc.identifier.scopuseid_2-s2.0-0027394517en_US
dc.identifier.issue287en_US
dc.identifier.spage286en_US
dc.identifier.epage291en_US
dc.identifier.isiWOS:A1993KR84400044-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYe, Z=7401957016en_US
dc.identifier.scopusauthoridWood, MB=7403448994en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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