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Article: Indapamide inhibits endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat

TitleIndapamide inhibits endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat
Authors
Issue Date1993
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/FCP
Citation
Fundamental And Clinical Pharmacology, 1993, v. 7 n. 8, p. 443-448 How to Cite?
AbstractExperiments were designed to determine whether or not indapamide, an antihypertensive agent with vasodilator properties, inhibits endothelium-dependent contractions. Rings of aortae with and without endothelium from spontaneously hypertensive rats (SHR) were suspended in conventional organ chambers for the measurement of isometric force. Acetylcholine and adenosine diphosphate-β-S in the presence of a nitric oxide synthase inhibitor, caused endothelium-dependent contractions, which were inhibited by indapamide. The compound (10-4M) also slightly reduced the contractions of rigns without endothelium evoked by I-46,619, which activates thromboxane-endoperoxide receptors. These results demonstrate that indapamide inhibits endothelium-dependent contractions in the SHR aorta, and suggest that the inhibition is due, at least in part, to the action of the drug on the hypertensive vascular smooth muscle.
Persistent Identifierhttp://hdl.handle.net/10722/171097
ISSN
2015 Impact Factor: 2.156
2015 SCImago Journal Rankings: 0.624
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBoulanger, CMen_US
dc.contributor.authorMombouli, JVen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:10Z-
dc.date.available2012-10-30T06:12:10Z-
dc.date.issued1993en_US
dc.identifier.citationFundamental And Clinical Pharmacology, 1993, v. 7 n. 8, p. 443-448en_US
dc.identifier.issn0767-3981en_US
dc.identifier.urihttp://hdl.handle.net/10722/171097-
dc.description.abstractExperiments were designed to determine whether or not indapamide, an antihypertensive agent with vasodilator properties, inhibits endothelium-dependent contractions. Rings of aortae with and without endothelium from spontaneously hypertensive rats (SHR) were suspended in conventional organ chambers for the measurement of isometric force. Acetylcholine and adenosine diphosphate-β-S in the presence of a nitric oxide synthase inhibitor, caused endothelium-dependent contractions, which were inhibited by indapamide. The compound (10-4M) also slightly reduced the contractions of rigns without endothelium evoked by I-46,619, which activates thromboxane-endoperoxide receptors. These results demonstrate that indapamide inhibits endothelium-dependent contractions in the SHR aorta, and suggest that the inhibition is due, at least in part, to the action of the drug on the hypertensive vascular smooth muscle.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/FCPen_US
dc.relation.ispartofFundamental and Clinical Pharmacologyen_US
dc.subject.mesh15-Hydroxy-11 Alpha,9 Alpha-(Epoxymethano)Prosta-5,13-Dienoic Aciden_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAdenosine Diphosphate - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAorta, Thoracic - Drug Effects - Physiologyen_US
dc.subject.meshEndothelium, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshHypertension - Drug Therapy - Physiopathologyen_US
dc.subject.meshIndapamide - Pharmacologyen_US
dc.subject.meshKineticsen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshProstaglandin Endoperoxides, Synthetic - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Shren_US
dc.subject.meshReceptors, Thromboxane - Drug Effects - Physiologyen_US
dc.subject.meshThromboxane A2 - Analogs & Derivatives - Pharmacologyen_US
dc.titleIndapamide inhibits endothelium-dependent contractions in the aorta of the spontaneously hypertensive raten_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1472-8206.1993.tb01040.x-
dc.identifier.pmid8294082en_US
dc.identifier.scopuseid_2-s2.0-0027365342en_US
dc.identifier.volume7en_US
dc.identifier.issue8en_US
dc.identifier.spage443en_US
dc.identifier.epage448en_US
dc.identifier.isiWOS:A1993MD76600006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridBoulanger, CM=7006599024en_US
dc.identifier.scopusauthoridMombouli, JV=7004285772en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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