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Article: Contractions to endothelin in normotensive and spontaneously hypertensive rats: role of endothelium and prostaglandins.

TitleContractions to endothelin in normotensive and spontaneously hypertensive rats: role of endothelium and prostaglandins.
Authors
Issue Date1992
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/08037051.html
Citation
Blood Pressure, 1992, v. 1 n. 1, p. 45-49 How to Cite?
AbstractContractions to endothelin-1 in aortas of the spontaneously hypertensive rats (SHR) were compared with those of normotensive controls (WKY); rings with and without endothelium were studied in organ chambers. Contractions to endothelin were smaller in aortas of SHR compared to WKY, whether the endothelium was present or not. The presence of a functional endothelium reduced contractions to the peptide in both strains. Endothelium-dependent relaxations to acetylcholine and endothelium-independent relaxations to nitric oxide were observed in rings from both strains during contraction with endothelin. Indomethacin reduced the contractions to endothelin in the aorta from SHR with endothelium, but not in those without endothelium; it did not significantly affect endothelin-induced contractions in rings of WKY with or without endothelium. These experiments demonstrate that contractions of the vascular smooth muscle to endothelin are reduced in the aorta of the SHR. The basal and stimulated release of endothelium-derived relaxing factor inhibits contractions to endothelin in the aorta from both strains. The inhibitor of cyclooxygenase indomethacin does not prevent the response of the vascular smooth muscle to endothelin; however, endothelin may stimulate the release of an indomethacin-sensitive endothelium-derived contracting factor in the SHR aorta.
Persistent Identifierhttp://hdl.handle.net/10722/171077
ISSN
2015 Impact Factor: 2.01
2015 SCImago Journal Rankings: 0.732

 

DC FieldValueLanguage
dc.contributor.authorAuchSchwelk, Wen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:06Z-
dc.date.available2012-10-30T06:12:06Z-
dc.date.issued1992en_US
dc.identifier.citationBlood Pressure, 1992, v. 1 n. 1, p. 45-49en_US
dc.identifier.issn0803-7051en_US
dc.identifier.urihttp://hdl.handle.net/10722/171077-
dc.description.abstractContractions to endothelin-1 in aortas of the spontaneously hypertensive rats (SHR) were compared with those of normotensive controls (WKY); rings with and without endothelium were studied in organ chambers. Contractions to endothelin were smaller in aortas of SHR compared to WKY, whether the endothelium was present or not. The presence of a functional endothelium reduced contractions to the peptide in both strains. Endothelium-dependent relaxations to acetylcholine and endothelium-independent relaxations to nitric oxide were observed in rings from both strains during contraction with endothelin. Indomethacin reduced the contractions to endothelin in the aorta from SHR with endothelium, but not in those without endothelium; it did not significantly affect endothelin-induced contractions in rings of WKY with or without endothelium. These experiments demonstrate that contractions of the vascular smooth muscle to endothelin are reduced in the aorta of the SHR. The basal and stimulated release of endothelium-derived relaxing factor inhibits contractions to endothelin in the aorta from both strains. The inhibitor of cyclooxygenase indomethacin does not prevent the response of the vascular smooth muscle to endothelin; however, endothelin may stimulate the release of an indomethacin-sensitive endothelium-derived contracting factor in the SHR aorta.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/08037051.htmlen_US
dc.relation.ispartofBlood pressureen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAorta - Drug Effectsen_US
dc.subject.meshEndothelins - Pharmacologyen_US
dc.subject.meshEndothelium, Vascular - Physiologyen_US
dc.subject.meshIndomethacin - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNitric Oxide - Pharmacologyen_US
dc.subject.meshProstaglandins - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Shr - Physiologyen_US
dc.subject.meshRats, Inbred Wkyen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.titleContractions to endothelin in normotensive and spontaneously hypertensive rats: role of endothelium and prostaglandins.en_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1345142-
dc.identifier.scopuseid_2-s2.0-0026864793en_US
dc.identifier.volume1en_US
dc.identifier.issue1en_US
dc.identifier.spage45en_US
dc.identifier.epage49en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridAuchSchwelk, W=7003395589en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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