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Article: Hypotonic solutions induce epithelium-dependent relaxation of isolated canine bronchi

TitleHypotonic solutions induce epithelium-dependent relaxation of isolated canine bronchi
Authors
Issue Date1992
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00408/
Citation
Lung, 1992, v. 170 n. 6, p. 339-347 How to Cite?
AbstractThe present study was designed to investigate the effect of changes in osmolarity on the modulatory role of the respiratory epithelium on the underlying smooth muscle. Canine bronchial segments with or without epithelium were perfused intraluminally with modified Krebs-Ringer bicarbonate solution. The transluminal isometric tension was recorded by means of stirrups passed through the bronchial wall. During contractions to extraluminal carbachol, the tissues with epithelium exhibited epithelium-dependent relaxations to hypotonic solution given intraluminally. The level of relaxation was dependent on the osmotic pressure. No significant difference was noted between relaxations due to hypotonic solution made by mixing the Krebs-Ringer solution with distilled water and those made by decreasing the concentration of sodium chloride. The epithelium-dependent relaxations could not be blocked by the antagonists or blockers of cyclo-oxygenase, endothelium-derived relaxing factor, α-adrenoceptors, β-adrenoceptors, and sodium channels. No evidence for the release of a relaxing factor into the bronchial lumen was found in bioassay study. When the preparation was stimulated with hypertonic solutions prepared by adding mannitol or urea, similar relaxations were induced in tissues with and without epithelium. These observations suggest that changes in osmolarity affect the responses of canine bronchi to carbachol and that the epithelium modulates the responses of airway to hypotonic solutions.
Persistent Identifierhttp://hdl.handle.net/10722/171074
ISSN
2015 Impact Factor: 2.0
2015 SCImago Journal Rankings: 0.785
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGao, Yen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:05Z-
dc.date.available2012-10-30T06:12:05Z-
dc.date.issued1992en_US
dc.identifier.citationLung, 1992, v. 170 n. 6, p. 339-347en_US
dc.identifier.issn0341-2040en_US
dc.identifier.urihttp://hdl.handle.net/10722/171074-
dc.description.abstractThe present study was designed to investigate the effect of changes in osmolarity on the modulatory role of the respiratory epithelium on the underlying smooth muscle. Canine bronchial segments with or without epithelium were perfused intraluminally with modified Krebs-Ringer bicarbonate solution. The transluminal isometric tension was recorded by means of stirrups passed through the bronchial wall. During contractions to extraluminal carbachol, the tissues with epithelium exhibited epithelium-dependent relaxations to hypotonic solution given intraluminally. The level of relaxation was dependent on the osmotic pressure. No significant difference was noted between relaxations due to hypotonic solution made by mixing the Krebs-Ringer solution with distilled water and those made by decreasing the concentration of sodium chloride. The epithelium-dependent relaxations could not be blocked by the antagonists or blockers of cyclo-oxygenase, endothelium-derived relaxing factor, α-adrenoceptors, β-adrenoceptors, and sodium channels. No evidence for the release of a relaxing factor into the bronchial lumen was found in bioassay study. When the preparation was stimulated with hypertonic solutions prepared by adding mannitol or urea, similar relaxations were induced in tissues with and without epithelium. These observations suggest that changes in osmolarity affect the responses of canine bronchi to carbachol and that the epithelium modulates the responses of airway to hypotonic solutions.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00408/en_US
dc.relation.ispartofLungen_US
dc.subject.meshAirway Resistance - Drug Effects - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBronchi - Drug Effects - Physiologyen_US
dc.subject.meshCulture Techniquesen_US
dc.subject.meshDogsen_US
dc.subject.meshEpithelium - Drug Effects - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHypertonic Solutions - Pharmacologyen_US
dc.subject.meshHypotonic Solutions - Pharmacologyen_US
dc.subject.meshIsotonic Solutions - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMannitol - Pharmacologyen_US
dc.subject.meshNitric Oxide - Physiologyen_US
dc.subject.meshUrea - Pharmacologyen_US
dc.titleHypotonic solutions induce epithelium-dependent relaxation of isolated canine bronchien_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1434784-
dc.identifier.scopuseid_2-s2.0-0026768967en_US
dc.identifier.volume170en_US
dc.identifier.issue6en_US
dc.identifier.spage339en_US
dc.identifier.epage347en_US
dc.identifier.isiWOS:A1992JR51600004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGao, Y=7404706442en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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