File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The effect of methyl-lidocaine on the biosynthesis of phospholipids de novo in the isolated hamster heart

TitleThe effect of methyl-lidocaine on the biosynthesis of phospholipids de novo in the isolated hamster heart
Authors
Issue Date1992
PublisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.org
Citation
Biochemical Journal, 1992, v. 285 n. 1, p. 161-166 How to Cite?
AbstractMethyl-lidocaine is an amphiphilic agent which has been used as an experimental anti-arrhythmic drug. When hamster hearts were perfused with labelled glycerol, the presence of methyl-lidocaine in the perfusate was found to enhance the labelling in phosphatidylserine, phosphatidylinositol, diacylglycerol and triacylglycerol. However, the labelling of phosphatidylcholine and phosphatidylethanolamine was not significantly changed by methyl-lidocaine treatment. Assays in vitro for the enzymes involved in the synthesis of neutral lipids and acidic phospholipids revealed that phosphatidate phosphatase and CTP:phosphatidate cytidylyltransferase activities were stimulated by methyl-lidocaine. The intracellular pool sizes of diacylglycerol and CDP-diacylglycerol were also elevated. We postulate that the enhanced syntheses of the neutral lipids and acidic phospholipids in the methyl-lidocaine-perfused heart were mediated via the direct activation of the key enzymes in the biosynthesis of these lipids de noco.
Persistent Identifierhttp://hdl.handle.net/10722/171065
ISSN
2015 Impact Factor: 3.562
2015 SCImago Journal Rankings: 2.582
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTardi, PGen_US
dc.contributor.authorMan, RYKen_US
dc.contributor.authorChoy, PCen_US
dc.date.accessioned2012-10-30T06:12:03Z-
dc.date.available2012-10-30T06:12:03Z-
dc.date.issued1992en_US
dc.identifier.citationBiochemical Journal, 1992, v. 285 n. 1, p. 161-166en_US
dc.identifier.issn0264-6021en_US
dc.identifier.urihttp://hdl.handle.net/10722/171065-
dc.description.abstractMethyl-lidocaine is an amphiphilic agent which has been used as an experimental anti-arrhythmic drug. When hamster hearts were perfused with labelled glycerol, the presence of methyl-lidocaine in the perfusate was found to enhance the labelling in phosphatidylserine, phosphatidylinositol, diacylglycerol and triacylglycerol. However, the labelling of phosphatidylcholine and phosphatidylethanolamine was not significantly changed by methyl-lidocaine treatment. Assays in vitro for the enzymes involved in the synthesis of neutral lipids and acidic phospholipids revealed that phosphatidate phosphatase and CTP:phosphatidate cytidylyltransferase activities were stimulated by methyl-lidocaine. The intracellular pool sizes of diacylglycerol and CDP-diacylglycerol were also elevated. We postulate that the enhanced syntheses of the neutral lipids and acidic phospholipids in the methyl-lidocaine-perfused heart were mediated via the direct activation of the key enzymes in the biosynthesis of these lipids de noco.en_US
dc.languageengen_US
dc.publisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.orgen_US
dc.relation.ispartofBiochemical Journalen_US
dc.subject.meshAcyl Coenzyme A - Metabolismen_US
dc.subject.meshAcyltransferases - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Arrhythmia Agents - Pharmacologyen_US
dc.subject.meshChlorpromazine - Pharmacologyen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshDiacylglycerol O-Acyltransferaseen_US
dc.subject.meshDiglycerides - Metabolismen_US
dc.subject.meshGlycerol-3-Phosphate O-Acyltransferase - Metabolismen_US
dc.subject.meshHeart - Drug Effectsen_US
dc.subject.meshLidocaine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshMesocricetusen_US
dc.subject.meshMyocardium - Metabolismen_US
dc.subject.meshNucleotidyltransferases - Metabolismen_US
dc.subject.meshPhosphatidate Phosphatase - Metabolismen_US
dc.subject.meshPhospholipids - Biosynthesis - Metabolismen_US
dc.subject.meshTriglycerides - Metabolismen_US
dc.titleThe effect of methyl-lidocaine on the biosynthesis of phospholipids de novo in the isolated hamster hearten_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1322123-
dc.identifier.scopuseid_2-s2.0-0026689241en_US
dc.identifier.volume285en_US
dc.identifier.issue1en_US
dc.identifier.spage161en_US
dc.identifier.epage166en_US
dc.identifier.isiWOS:A1992JC92400027-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridTardi, PG=36805754700en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US
dc.identifier.scopusauthoridChoy, PC=7006633002en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats