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Article: Effects of S14001 on adrenergic neuroeffector interaction in isolated canine saphenous veins

TitleEffects of S14001 on adrenergic neuroeffector interaction in isolated canine saphenous veins
Authors
Issue Date1992
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vph
Citation
General Pharmacology, 1992, v. 23 n. 5, p. 867-872 How to Cite?
AbstractThe effects of (S)fluoro-6(morpholinyl-2 methoxy)-8-tetrahydro-1,2,3,4 quinoleine (S14001) on adrenergic neurotransmission in isolated canine saphenous veins were investigated in experiments which measured the accumulation, overflow and metabolism of 3H-norepinephrine. S14001 inhibited the accumulation of total tritium (3H-norepinephrine and 3H-metabolites of norepinephrine) in a concentration-dependent manner. Under basal conditions, S14001 increased tension and basal efflux of total tritium; the latter consisted predominantly of 3H-DOPEG. The increases in these parameters were not inhibited by desmethylimipramine (DMI). During electrical stimulation, S14001 increased the contraction and overflow of total tritium; the latter consisted predominantly of 3H-DOPEG. The increases in these parameters were inhibited by DMI. These experiments suggest that S14001 has dual effects on adrenergic neurotransmission in the canine saphenous vein: (a) an inhibitory action on the neuronal acumulation; and (b) a pharmacological displacement of the transmitter from adrenergic nerve terminals.
Persistent Identifierhttp://hdl.handle.net/10722/171062
ISSN
2002 Impact Factor: 0.591
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHoshino, Yen_US
dc.contributor.authorVerbeuren, TJen_US
dc.contributor.authorHughes, Hen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:12:02Z-
dc.date.available2012-10-30T06:12:02Z-
dc.date.issued1992en_US
dc.identifier.citationGeneral Pharmacology, 1992, v. 23 n. 5, p. 867-872en_US
dc.identifier.issn0306-3623en_US
dc.identifier.urihttp://hdl.handle.net/10722/171062-
dc.description.abstractThe effects of (S)fluoro-6(morpholinyl-2 methoxy)-8-tetrahydro-1,2,3,4 quinoleine (S14001) on adrenergic neurotransmission in isolated canine saphenous veins were investigated in experiments which measured the accumulation, overflow and metabolism of 3H-norepinephrine. S14001 inhibited the accumulation of total tritium (3H-norepinephrine and 3H-metabolites of norepinephrine) in a concentration-dependent manner. Under basal conditions, S14001 increased tension and basal efflux of total tritium; the latter consisted predominantly of 3H-DOPEG. The increases in these parameters were not inhibited by desmethylimipramine (DMI). During electrical stimulation, S14001 increased the contraction and overflow of total tritium; the latter consisted predominantly of 3H-DOPEG. The increases in these parameters were inhibited by DMI. These experiments suggest that S14001 has dual effects on adrenergic neurotransmission in the canine saphenous vein: (a) an inhibitory action on the neuronal acumulation; and (b) a pharmacological displacement of the transmitter from adrenergic nerve terminals.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vphen_US
dc.relation.ispartofGeneral Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntidepressive Agents - Pharmacologyen_US
dc.subject.meshDesipramine - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshIsometric Contraction - Drug Effectsen_US
dc.subject.meshMorpholines - Pharmacologyen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Innervationen_US
dc.subject.meshNeuroeffector Junction - Drug Effects - Physiologyen_US
dc.subject.meshNorepinephrine - Metabolismen_US
dc.subject.meshQuinolines - Pharmacologyen_US
dc.subject.meshReceptors, Adrenergic - Drug Effects - Physiologyen_US
dc.subject.meshSaphenous Veinen_US
dc.titleEffects of S14001 on adrenergic neuroeffector interaction in isolated canine saphenous veinsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0306-3623(92)90239-Gen_US
dc.identifier.pmid1426930-
dc.identifier.scopuseid_2-s2.0-0026666746en_US
dc.identifier.volume23en_US
dc.identifier.issue5en_US
dc.identifier.spage867en_US
dc.identifier.epage872en_US
dc.identifier.isiWOS:A1992JL89800013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHoshino, Y=7202851283en_US
dc.identifier.scopusauthoridVerbeuren, TJ=7007006534en_US
dc.identifier.scopusauthoridHughes, H=7202659303en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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