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Article: Role of peptido-leukotrienes in the genesis of early ventricular arrhythmias during acute myocardial ischaemia in rats

TitleRole of peptido-leukotrienes in the genesis of early ventricular arrhythmias during acute myocardial ischaemia in rats
Authors
Issue Date1992
Citation
Agents And Actions, 1992, v. 35 n. 3-4, p. 212-219 How to Cite?
AbstractChanges in cardiac ventricular concentrations of peptidoleukotrienes (peptido-LTs) following coronary artery ligation and the effects of lipoxygenase inhibition and leukotriene antagonism on the cardiovascular responses to acute myocardial ischaemia were studied in pentobarbitone-anaesthetised rats. It was found that the left ventricular peptido-LT levels significantly increased at 2.5 and 5 min after left coronary artery ligation while the changes in right ventricle were not statistically significant. Pretreatment with nordihydroguaiaretic acid 25, 50 or 100mg/kg caused marked depletion of ventricular peptido-LT content, but did not significantly prevent the blood pressure or heart rate changes, the occurrence of ventricular tachycardia or fibrillation, or the mortality of the animals following coronary artery ligation. Administration of SK and F 102922, even at doses which caused marked decreases in blood pressure and heart rate, also did not significantly alter the cardiovascular changes and the mortality rate induced by left coronary artery ligation. It is, therefore, suggested that the occurrence of ventricular arrhythmias and haemodynamic changes during the early phase of acute myocardial ischaemia may not be due to the augmented synthesis of peptido-LTs in cardiac tissue.
Persistent Identifierhttp://hdl.handle.net/10722/171049
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChang, ACCen_US
dc.contributor.authorDai, Sen_US
dc.contributor.authorOgle, CWen_US
dc.contributor.authorTom, WMen_US
dc.date.accessioned2012-10-30T06:11:59Z-
dc.date.available2012-10-30T06:11:59Z-
dc.date.issued1992en_US
dc.identifier.citationAgents And Actions, 1992, v. 35 n. 3-4, p. 212-219en_US
dc.identifier.issn0065-4299en_US
dc.identifier.urihttp://hdl.handle.net/10722/171049-
dc.description.abstractChanges in cardiac ventricular concentrations of peptidoleukotrienes (peptido-LTs) following coronary artery ligation and the effects of lipoxygenase inhibition and leukotriene antagonism on the cardiovascular responses to acute myocardial ischaemia were studied in pentobarbitone-anaesthetised rats. It was found that the left ventricular peptido-LT levels significantly increased at 2.5 and 5 min after left coronary artery ligation while the changes in right ventricle were not statistically significant. Pretreatment with nordihydroguaiaretic acid 25, 50 or 100mg/kg caused marked depletion of ventricular peptido-LT content, but did not significantly prevent the blood pressure or heart rate changes, the occurrence of ventricular tachycardia or fibrillation, or the mortality of the animals following coronary artery ligation. Administration of SK and F 102922, even at doses which caused marked decreases in blood pressure and heart rate, also did not significantly alter the cardiovascular changes and the mortality rate induced by left coronary artery ligation. It is, therefore, suggested that the occurrence of ventricular arrhythmias and haemodynamic changes during the early phase of acute myocardial ischaemia may not be due to the augmented synthesis of peptido-LTs in cardiac tissue.en_US
dc.languageengen_US
dc.relation.ispartofAgents and Actionsen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArrhythmias, Cardiac - Etiology - Physiopathologyen_US
dc.subject.meshArteriesen_US
dc.subject.meshCardiovascular System - Physiopathologyen_US
dc.subject.meshCoronary Disease - Complicationsen_US
dc.subject.meshCoronary Vesselsen_US
dc.subject.meshDicarboxylic Acids - Pharmacologyen_US
dc.subject.meshHeart Ventricles - Metabolismen_US
dc.subject.meshLeukotriene Antagonistsen_US
dc.subject.meshLeukotrienes - Physiologyen_US
dc.subject.meshLipoxygenase Inhibitors - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNordihydroguaiaretic Acid - Pharmacologyen_US
dc.subject.meshPeptides - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshTime Factorsen_US
dc.titleRole of peptido-leukotrienes in the genesis of early ventricular arrhythmias during acute myocardial ischaemia in ratsen_US
dc.typeArticleen_US
dc.identifier.emailTom, WM:wmtoma@hkucc.hku.hken_US
dc.identifier.authorityTom, WM=rp00237en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF01997502-
dc.identifier.pmid1529795-
dc.identifier.scopuseid_2-s2.0-0026529986en_US
dc.identifier.volume35en_US
dc.identifier.issue3-4en_US
dc.identifier.spage212en_US
dc.identifier.epage219en_US
dc.identifier.isiWOS:A1992HQ93500011-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridChang, ACC=7402539335en_US
dc.identifier.scopusauthoridDai, S=7203008763en_US
dc.identifier.scopusauthoridOgle, CW=7103150233en_US
dc.identifier.scopusauthoridTom, WM=7003709519en_US

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