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Article: Effects of S-11701 on accumulation, release and metabolism of norepinephrine in isolated canine saphenous veins

TitleEffects of S-11701 on accumulation, release and metabolism of norepinephrine in isolated canine saphenous veins
Authors
Issue Date1992
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vph
Citation
General Pharmacology, 1992, v. 23 n. 6, p. 1079-1085 How to Cite?
Abstract1. The effects S-11701 ([morpholinyl-2)-methoxy]-8-tetrahydro-1,2,3,4-quinoleine) on accumulation, overflow and metabolism of [ 3H]norepinephrine were investigated in isolated canine saphenous veins. 2. Saphenous veins were incubated with [ 3H]norepinephrine in the absence or the presence of S-11701; the drug caused a concentration-dependent inhibition of the tissue content of [ 3H]norepinephrine and its metabolites, except for 3-methoxy-4-hydroxymandelic acid (VMA). 3. In helical strips of canine saphenous veins previously incubated with [ 3H]norepinephrine and then suspended for isometric tension recording and measurement of the overflow of labelled transmitter and its metabolites, S-11701 (30 μM) significantly increased the spontaneous efflux of total 3H; this effect was almost exclusively due to an augmentation of the efflux of [ 3H]DOPEG. 4. During electrical stimulation (9 V, 1 Hz), S-11701 at 1 μM slightly increased the overflow of extraneuronal norepinephrine metabolites without affecting the contractile response. At the higher concentration (30μM) the compound increased the contractive response and the overflow of 3H; the latter was due mainly to an increase in [ 3H]DOPEG and, to a lesser extent, in [ 3H]norepinephrine. 5. DMI (1 μM) did not interfere with the effects of S-11701 on DOPEG efflux. 6. These experiments indicate that in the canine saphenous vein, S-11701 causes a concentration-dependent inhibition of neuronal accumulation of [ 3H]norepinephrine. At higher concentrations, S-11701 enters the adrenergic nerve terminals independently of the neuronal amine carrier and displaces [ 3H]norepinephrine from its storage sites.
Persistent Identifierhttp://hdl.handle.net/10722/171044
ISSN
2002 Impact Factor: 0.591
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGuo, HYen_US
dc.contributor.authorLorenz, RRen_US
dc.contributor.authorVerbeuren, TJen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:58Z-
dc.date.available2012-10-30T06:11:58Z-
dc.date.issued1992en_US
dc.identifier.citationGeneral Pharmacology, 1992, v. 23 n. 6, p. 1079-1085en_US
dc.identifier.issn0306-3623en_US
dc.identifier.urihttp://hdl.handle.net/10722/171044-
dc.description.abstract1. The effects S-11701 ([morpholinyl-2)-methoxy]-8-tetrahydro-1,2,3,4-quinoleine) on accumulation, overflow and metabolism of [ 3H]norepinephrine were investigated in isolated canine saphenous veins. 2. Saphenous veins were incubated with [ 3H]norepinephrine in the absence or the presence of S-11701; the drug caused a concentration-dependent inhibition of the tissue content of [ 3H]norepinephrine and its metabolites, except for 3-methoxy-4-hydroxymandelic acid (VMA). 3. In helical strips of canine saphenous veins previously incubated with [ 3H]norepinephrine and then suspended for isometric tension recording and measurement of the overflow of labelled transmitter and its metabolites, S-11701 (30 μM) significantly increased the spontaneous efflux of total 3H; this effect was almost exclusively due to an augmentation of the efflux of [ 3H]DOPEG. 4. During electrical stimulation (9 V, 1 Hz), S-11701 at 1 μM slightly increased the overflow of extraneuronal norepinephrine metabolites without affecting the contractile response. At the higher concentration (30μM) the compound increased the contractive response and the overflow of 3H; the latter was due mainly to an increase in [ 3H]DOPEG and, to a lesser extent, in [ 3H]norepinephrine. 5. DMI (1 μM) did not interfere with the effects of S-11701 on DOPEG efflux. 6. These experiments indicate that in the canine saphenous vein, S-11701 causes a concentration-dependent inhibition of neuronal accumulation of [ 3H]norepinephrine. At higher concentrations, S-11701 enters the adrenergic nerve terminals independently of the neuronal amine carrier and displaces [ 3H]norepinephrine from its storage sites.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vphen_US
dc.relation.ispartofGeneral Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDesipramine - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshIsometric Contraction - Drug Effectsen_US
dc.subject.meshMethoxyhydroxyphenylglycol - Analogs & Derivatives - Metabolismen_US
dc.subject.meshMorpholines - Pharmacologyen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Metabolismen_US
dc.subject.meshNeurons - Drug Effects - Metabolismen_US
dc.subject.meshNeurotransmitter Uptake Inhibitors - Pharmacologyen_US
dc.subject.meshNorepinephrine - Metabolismen_US
dc.subject.meshQuinolines - Pharmacologyen_US
dc.subject.meshSaphenous Vein - Drug Effects - Metabolismen_US
dc.subject.meshVanilmandelic Acid - Metabolismen_US
dc.titleEffects of S-11701 on accumulation, release and metabolism of norepinephrine in isolated canine saphenous veinsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0306-3623(92)90290-Zen_US
dc.identifier.pmid1487118-
dc.identifier.scopuseid_2-s2.0-0026452329en_US
dc.identifier.volume23en_US
dc.identifier.issue6en_US
dc.identifier.spage1079en_US
dc.identifier.epage1085en_US
dc.identifier.isiWOS:A1992KB81600021-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGuo, HY=7404404410en_US
dc.identifier.scopusauthoridLorenz, RR=7402095192en_US
dc.identifier.scopusauthoridVerbeuren, TJ=7007006534en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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