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- Publisher Website: 10.1016/0306-3623(92)90290-Z
- Scopus: eid_2-s2.0-0026452329
- PMID: 1487118
- WOS: WOS:A1992KB81600021
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Article: Effects of S-11701 on accumulation, release and metabolism of norepinephrine in isolated canine saphenous veins
Title | Effects of S-11701 on accumulation, release and metabolism of norepinephrine in isolated canine saphenous veins |
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Authors | |
Issue Date | 1992 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vph |
Citation | General Pharmacology, 1992, v. 23 n. 6, p. 1079-1085 How to Cite? |
Abstract | 1. The effects S-11701 ([morpholinyl-2)-methoxy]-8-tetrahydro-1,2,3,4-quinoleine) on accumulation, overflow and metabolism of [ 3H]norepinephrine were investigated in isolated canine saphenous veins. 2. Saphenous veins were incubated with [ 3H]norepinephrine in the absence or the presence of S-11701; the drug caused a concentration-dependent inhibition of the tissue content of [ 3H]norepinephrine and its metabolites, except for 3-methoxy-4-hydroxymandelic acid (VMA). 3. In helical strips of canine saphenous veins previously incubated with [ 3H]norepinephrine and then suspended for isometric tension recording and measurement of the overflow of labelled transmitter and its metabolites, S-11701 (30 μM) significantly increased the spontaneous efflux of total 3H; this effect was almost exclusively due to an augmentation of the efflux of [ 3H]DOPEG. 4. During electrical stimulation (9 V, 1 Hz), S-11701 at 1 μM slightly increased the overflow of extraneuronal norepinephrine metabolites without affecting the contractile response. At the higher concentration (30μM) the compound increased the contractive response and the overflow of 3H; the latter was due mainly to an increase in [ 3H]DOPEG and, to a lesser extent, in [ 3H]norepinephrine. 5. DMI (1 μM) did not interfere with the effects of S-11701 on DOPEG efflux. 6. These experiments indicate that in the canine saphenous vein, S-11701 causes a concentration-dependent inhibition of neuronal accumulation of [ 3H]norepinephrine. At higher concentrations, S-11701 enters the adrenergic nerve terminals independently of the neuronal amine carrier and displaces [ 3H]norepinephrine from its storage sites. |
Persistent Identifier | http://hdl.handle.net/10722/171044 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Guo, HY | en_US |
dc.contributor.author | Lorenz, RR | en_US |
dc.contributor.author | Verbeuren, TJ | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:58Z | - |
dc.date.available | 2012-10-30T06:11:58Z | - |
dc.date.issued | 1992 | en_US |
dc.identifier.citation | General Pharmacology, 1992, v. 23 n. 6, p. 1079-1085 | en_US |
dc.identifier.issn | 0306-3623 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/171044 | - |
dc.description.abstract | 1. The effects S-11701 ([morpholinyl-2)-methoxy]-8-tetrahydro-1,2,3,4-quinoleine) on accumulation, overflow and metabolism of [ 3H]norepinephrine were investigated in isolated canine saphenous veins. 2. Saphenous veins were incubated with [ 3H]norepinephrine in the absence or the presence of S-11701; the drug caused a concentration-dependent inhibition of the tissue content of [ 3H]norepinephrine and its metabolites, except for 3-methoxy-4-hydroxymandelic acid (VMA). 3. In helical strips of canine saphenous veins previously incubated with [ 3H]norepinephrine and then suspended for isometric tension recording and measurement of the overflow of labelled transmitter and its metabolites, S-11701 (30 μM) significantly increased the spontaneous efflux of total 3H; this effect was almost exclusively due to an augmentation of the efflux of [ 3H]DOPEG. 4. During electrical stimulation (9 V, 1 Hz), S-11701 at 1 μM slightly increased the overflow of extraneuronal norepinephrine metabolites without affecting the contractile response. At the higher concentration (30μM) the compound increased the contractive response and the overflow of 3H; the latter was due mainly to an increase in [ 3H]DOPEG and, to a lesser extent, in [ 3H]norepinephrine. 5. DMI (1 μM) did not interfere with the effects of S-11701 on DOPEG efflux. 6. These experiments indicate that in the canine saphenous vein, S-11701 causes a concentration-dependent inhibition of neuronal accumulation of [ 3H]norepinephrine. At higher concentrations, S-11701 enters the adrenergic nerve terminals independently of the neuronal amine carrier and displaces [ 3H]norepinephrine from its storage sites. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/vph | en_US |
dc.relation.ispartof | General Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Desipramine - Pharmacology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Electric Stimulation | en_US |
dc.subject.mesh | Isometric Contraction - Drug Effects | en_US |
dc.subject.mesh | Methoxyhydroxyphenylglycol - Analogs & Derivatives - Metabolism | en_US |
dc.subject.mesh | Morpholines - Pharmacology | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Neurons - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Neurotransmitter Uptake Inhibitors - Pharmacology | en_US |
dc.subject.mesh | Norepinephrine - Metabolism | en_US |
dc.subject.mesh | Quinolines - Pharmacology | en_US |
dc.subject.mesh | Saphenous Vein - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Vanilmandelic Acid - Metabolism | en_US |
dc.title | Effects of S-11701 on accumulation, release and metabolism of norepinephrine in isolated canine saphenous veins | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0306-3623(92)90290-Z | en_US |
dc.identifier.pmid | 1487118 | - |
dc.identifier.scopus | eid_2-s2.0-0026452329 | en_US |
dc.identifier.volume | 23 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 1079 | en_US |
dc.identifier.epage | 1085 | en_US |
dc.identifier.isi | WOS:A1992KB81600021 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Guo, HY=7404404410 | en_US |
dc.identifier.scopusauthorid | Lorenz, RR=7402095192 | en_US |
dc.identifier.scopusauthorid | Verbeuren, TJ=7007006534 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0306-3623 | - |