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Article: Heterogeneous distribution of endothelium-dependent relaxations resistant to N(G)-nitro-L-arginine in rats

TitleHeterogeneous distribution of endothelium-dependent relaxations resistant to N(G)-nitro-L-arginine in rats
Authors
Issue Date1992
PublisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/
Citation
American Journal Of Physiology - Heart And Circulatory Physiology, 1992, v. 263 n. 4 32-4, p. H1090-H1094 How to Cite?
AbstractEndothelium-dependent relaxations that are resistant to inhibitors of nitric oxide synthase probably are mediated by endothelium-dependent hyperpolarization of the vascular smooth muscle. Experiments were performed to examine the distribution of this type of relaxation along the arterial tree of the rat by measuring changes in isometric force. Acetylcholine induced concentration- and endothelium-dependent relaxations in aortas and in pulmonary, common iliac, femoral, mesenteric, and renal arteries contracted with phenylephrine. In the presence of N(G)-nitro-L-arginine, the cumulative administration of acetylcholine induced relaxations only in the femoral, mesenteric, and renal arteries. The calcium ionophore A23187 relaxed mesenteric arteries contracted with phenylephrine in a concentration- and endothelium-dependent manner. The concentration-relaxation curve to A23187 was shifted to the right in the presence of N(G)-nitro-L-arginine. The maximal relaxations induced by lemakalimq, a K+ channel opener, were smaller in those arteries that did not exhibit N(G)-nitro-L-arginine-resistant relaxations. These results suggest that N(G)-nitro-L-arginine-resistant relaxations are more frequently observed in smaller arteries. The arteries that exhibit N(G)-nitro-L-arginine-resistant relaxations may be more sensitive to an endothelium-derived substance that causes hyperpolarization of vascular smooth muscle cells.
Persistent Identifierhttp://hdl.handle.net/10722/171043
ISSN
1998 Impact Factor: 3.077
2004 SCImago Journal Rankings: 1.102

 

DC FieldValueLanguage
dc.contributor.authorNagao, Ten_US
dc.contributor.authorIlliano, Sen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:57Z-
dc.date.available2012-10-30T06:11:57Z-
dc.date.issued1992en_US
dc.identifier.citationAmerican Journal Of Physiology - Heart And Circulatory Physiology, 1992, v. 263 n. 4 32-4, p. H1090-H1094en_US
dc.identifier.issn0002-9513en_US
dc.identifier.urihttp://hdl.handle.net/10722/171043-
dc.description.abstractEndothelium-dependent relaxations that are resistant to inhibitors of nitric oxide synthase probably are mediated by endothelium-dependent hyperpolarization of the vascular smooth muscle. Experiments were performed to examine the distribution of this type of relaxation along the arterial tree of the rat by measuring changes in isometric force. Acetylcholine induced concentration- and endothelium-dependent relaxations in aortas and in pulmonary, common iliac, femoral, mesenteric, and renal arteries contracted with phenylephrine. In the presence of N(G)-nitro-L-arginine, the cumulative administration of acetylcholine induced relaxations only in the femoral, mesenteric, and renal arteries. The calcium ionophore A23187 relaxed mesenteric arteries contracted with phenylephrine in a concentration- and endothelium-dependent manner. The concentration-relaxation curve to A23187 was shifted to the right in the presence of N(G)-nitro-L-arginine. The maximal relaxations induced by lemakalimq, a K+ channel opener, were smaller in those arteries that did not exhibit N(G)-nitro-L-arginine-resistant relaxations. These results suggest that N(G)-nitro-L-arginine-resistant relaxations are more frequently observed in smaller arteries. The arteries that exhibit N(G)-nitro-L-arginine-resistant relaxations may be more sensitive to an endothelium-derived substance that causes hyperpolarization of vascular smooth muscle cells.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/en_US
dc.relation.ispartofAmerican Journal of Physiology - Heart and Circulatory Physiologyen_US
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArginine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshArteries - Drug Effectsen_US
dc.subject.meshCalcimycin - Pharmacologyen_US
dc.subject.meshEndothelium, Vascular - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNitroarginineen_US
dc.subject.meshPhenylephrine - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshVasodilation - Drug Effects - Physiologyen_US
dc.titleHeterogeneous distribution of endothelium-dependent relaxations resistant to N(G)-nitro-L-arginine in ratsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1415757-
dc.identifier.scopuseid_2-s2.0-0026438790en_US
dc.identifier.volume263en_US
dc.identifier.issue4 32-4en_US
dc.identifier.spageH1090en_US
dc.identifier.epageH1094en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNagao, T=7401489430en_US
dc.identifier.scopusauthoridIlliano, S=6602119848en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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