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Article: Endothelium-derived relaxing and contracting factors.

TitleEndothelium-derived relaxing and contracting factors.
Authors
Issue Date1991
PublisherSpringer-Verlag Wien. The Journal's web site is located at http://www.springer.at/wkw
Citation
Wiener Klinische Wochenschrift, 1991, v. 103 n. 14, p. 405-411 How to Cite?
AbstractSince the description of the essential role of the endothelium in mediating relaxations due to acetylcholine in mammalian arteries, it has become obvious that endothelial cells release several relaxing and contracting substances. The release is activated by a variety of agents including circulating hormones, autacoids, and products liberated by aggregating platelets, but also by changes in shear stress exerted by the blood. There is strong evidence that the major endothelium-derived relaxing factor (EDRF) is the free radical nitric oxide (NO) formed enzymatically from L-arginine. Endothelium-dependent relaxations caused by EDRF are induced through increases in the activity of soluble guanylate cyclase in the smooth muscle. Other relaxing factors, such as prostacyclin and endothelium-derived hyperpolarizing factor (EDHF) contribute to endothelium-dependent relaxations. Beside the recently described and chemically identified peptide endothelin, at least two other endothelium-derived contracting factors appear to exist. The mechanisms by which endothelium-derived contracting factors activate vascular smooth muscle are not yet clear. In certain clinical situations an impairment of the production of EDRF in face of a maintained or augmented release of contracting factors may contribute to the occurrence of localized vasospasm or generalized increases in peripheral resistance.
Persistent Identifierhttp://hdl.handle.net/10722/171023
ISSN
2015 Impact Factor: 0.836
2015 SCImago Journal Rankings: 0.291
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorEber, Ben_US
dc.date.accessioned2012-10-30T06:11:52Z-
dc.date.available2012-10-30T06:11:52Z-
dc.date.issued1991en_US
dc.identifier.citationWiener Klinische Wochenschrift, 1991, v. 103 n. 14, p. 405-411en_US
dc.identifier.issn0043-5325en_US
dc.identifier.urihttp://hdl.handle.net/10722/171023-
dc.description.abstractSince the description of the essential role of the endothelium in mediating relaxations due to acetylcholine in mammalian arteries, it has become obvious that endothelial cells release several relaxing and contracting substances. The release is activated by a variety of agents including circulating hormones, autacoids, and products liberated by aggregating platelets, but also by changes in shear stress exerted by the blood. There is strong evidence that the major endothelium-derived relaxing factor (EDRF) is the free radical nitric oxide (NO) formed enzymatically from L-arginine. Endothelium-dependent relaxations caused by EDRF are induced through increases in the activity of soluble guanylate cyclase in the smooth muscle. Other relaxing factors, such as prostacyclin and endothelium-derived hyperpolarizing factor (EDHF) contribute to endothelium-dependent relaxations. Beside the recently described and chemically identified peptide endothelin, at least two other endothelium-derived contracting factors appear to exist. The mechanisms by which endothelium-derived contracting factors activate vascular smooth muscle are not yet clear. In certain clinical situations an impairment of the production of EDRF in face of a maintained or augmented release of contracting factors may contribute to the occurrence of localized vasospasm or generalized increases in peripheral resistance.en_US
dc.languageengen_US
dc.publisherSpringer-Verlag Wien. The Journal's web site is located at http://www.springer.at/wkwen_US
dc.relation.ispartofWiener Klinische Wochenschriften_US
dc.subject.meshArteriosclerosis - Blooden_US
dc.subject.meshEndothelins - Physiologyen_US
dc.subject.meshEndothelium, Vascular - Physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshNitric Oxide - Physiologyen_US
dc.subject.meshThrombosis - Blooden_US
dc.subject.meshVasoconstriction - Physiologyen_US
dc.subject.meshVasodilation - Physiologyen_US
dc.titleEndothelium-derived relaxing and contracting factors.en_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1926867-
dc.identifier.scopuseid_2-s2.0-0025997996en_US
dc.identifier.volume103en_US
dc.identifier.issue14en_US
dc.identifier.spage405en_US
dc.identifier.epage411en_US
dc.identifier.isiWOS:A1991FX08600002-
dc.publisher.placeAustriaen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridEber, B=7101752857en_US

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