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Article: Characterization of the coronary vascular responses to platelet-activating factor in the isolated perfused heart

TitleCharacterization of the coronary vascular responses to platelet-activating factor in the isolated perfused heart
Authors
Issue Date1991
PublisherA O C S Press. The Journal's web site is located at http://www.aocs.org/press/lipids.htm
Citation
Lipids, 1991, v. 26 n. 9, p. 700-704 How to Cite?
AbstractPlatelet-activating factor (PAF) is a potent phospholipid mediator with diverse in vivo and in vitro coronary vascular effects. In the present study, the coronary vascular responses to bolus injections of PAF were compared in rat hearts perfused under constant flow and under constant pressure. Low levels of PAF (1 pmol) produced vasodilatation only, while higher PAF concentrations (100 pmol) produced initial vasodilatation which was followed by a vasoconstriction under both experimental conditions. To determine species differences in PAF action, the effect of PAF was tested on perfused guinea pig hearts. Unlike in perfused rat hearts, only a dose-dependent vasoconstrictor response was observed in perfused guinea pig hearts following a bolus injection of 1 fmol to 10 pmol of PAF. The results from repeated injections of PAF indicated that depletion of vasoactive mediators induced by PAF or receptor desensitization may explain a failure of a second injection of PAF to initiate a vasoconstrictor response. After PAF injection, the coronary vascular response to leukotriene was not altered, indicating that the reduced vasoconstrictor effect of a second injection of PAF cannot be due to a reduced ability of the smooth muscle to constrict. The study demonstrates that similar coronary vascular responses to PAF are observed in perfused rat hearts under either constant flow rate or constant pressure and that some of the variable coronary vascular responses reported may be due to the difference between animal species.
Persistent Identifierhttp://hdl.handle.net/10722/171015
ISSN
2015 Impact Factor: 1.892
2015 SCImago Journal Rankings: 0.795
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHu, Wen_US
dc.contributor.authorChoy, PCen_US
dc.contributor.authorMan, RYKen_US
dc.date.accessioned2012-10-30T06:11:50Z-
dc.date.available2012-10-30T06:11:50Z-
dc.date.issued1991en_US
dc.identifier.citationLipids, 1991, v. 26 n. 9, p. 700-704en_US
dc.identifier.issn0024-4201en_US
dc.identifier.urihttp://hdl.handle.net/10722/171015-
dc.description.abstractPlatelet-activating factor (PAF) is a potent phospholipid mediator with diverse in vivo and in vitro coronary vascular effects. In the present study, the coronary vascular responses to bolus injections of PAF were compared in rat hearts perfused under constant flow and under constant pressure. Low levels of PAF (1 pmol) produced vasodilatation only, while higher PAF concentrations (100 pmol) produced initial vasodilatation which was followed by a vasoconstriction under both experimental conditions. To determine species differences in PAF action, the effect of PAF was tested on perfused guinea pig hearts. Unlike in perfused rat hearts, only a dose-dependent vasoconstrictor response was observed in perfused guinea pig hearts following a bolus injection of 1 fmol to 10 pmol of PAF. The results from repeated injections of PAF indicated that depletion of vasoactive mediators induced by PAF or receptor desensitization may explain a failure of a second injection of PAF to initiate a vasoconstrictor response. After PAF injection, the coronary vascular response to leukotriene was not altered, indicating that the reduced vasoconstrictor effect of a second injection of PAF cannot be due to a reduced ability of the smooth muscle to constrict. The study demonstrates that similar coronary vascular responses to PAF are observed in perfused rat hearts under either constant flow rate or constant pressure and that some of the variable coronary vascular responses reported may be due to the difference between animal species.en_US
dc.languageengen_US
dc.publisherA O C S Press. The Journal's web site is located at http://www.aocs.org/press/lipids.htmen_US
dc.relation.ispartofLipidsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCoronary Circulation - Drug Effectsen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshHeart - Drug Effectsen_US
dc.subject.meshInjectionsen_US
dc.subject.meshPerfusionen_US
dc.subject.meshPlatelet Activating Factor - Pharmacologyen_US
dc.subject.meshPressureen_US
dc.subject.meshRatsen_US
dc.subject.meshSrs-A - Pharmacologyen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.titleCharacterization of the coronary vascular responses to platelet-activating factor in the isolated perfused hearten_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF02535617-
dc.identifier.pmid1762514-
dc.identifier.scopuseid_2-s2.0-0025916533en_US
dc.identifier.volume26en_US
dc.identifier.issue9en_US
dc.identifier.spage700en_US
dc.identifier.epage704en_US
dc.identifier.isiWOS:A1991GG74800005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHu, W=7404360099en_US
dc.identifier.scopusauthoridChoy, PC=7006633002en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US

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