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Article: Role of prostanoids in the increased vascular responsiveness and delayed tachyphylaxis to serotonin in the kidney of spontaneously hypertensive rats

TitleRole of prostanoids in the increased vascular responsiveness and delayed tachyphylaxis to serotonin in the kidney of spontaneously hypertensive rats
Authors
Issue Date1991
PublisherLippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jhypertension.com/
Citation
Journal Of Hypertension, 1991, v. 9 n. 7, p. 623-629 How to Cite?
AbstractThe isolated and perfused kidney of the spontaneously hypertensive rat (SHR) exhibits an increased vascular reactivity and a delayed tachyphylaxis to serotonin (5-hydroxytryptamine) when compared with normotensive Wistar-Kyoto (WKY) rats. Experiments were designed to determine the involvement of products of cyclooxygenase in the augmented response and delayed tachyphylaxis to serotonin in the SHR kidney. Kidneys taken from male, 4-month-old SHR and WKY rats were studied in parallel and perfused with Tyrode's solution at constant, optimal flow rates. Vasoconstrictor responses were recorded as increases in perfusion pressure. The vasoconstrictor responses to serotonin, norepinephrine and angiotensin II were exaggerated in the SHR kidney compared with that of the WKY rat. Indomethacin did not affect the responsiveness to serotonin in the kidney of the SHR but increased the responses to the higher doses of the monoamine in the kidney of the WKY rats. Indomethacin accelerated the tachyphylaxis to serotonin in the SHR but delayed it in the WKY rats. Dazoxiben did not alter the responses to serotonin in the SHR. Responses to norepinephrine in the kidneys from both strains were not affected by indomethacin. The inhibitor of cyclooxygenase reduced the responses to angiotensin II in the kidneys from both hypertensive and normotensive animals. The basal and stimulated (serotonin, norepinephrine and angiotensin II) release of prostaglandins were measured by radioimmunoassay. The basal release of prostacyclin was lower, but that of thromboxane A 2 higher, in the kidneys of SHR compared with those of WKY rats. These experiments suggest that a reduced release of vasodilator prostanoid and the increased release of a vasoconstrictor product of cyclooxygenase may contribute to the increased responsiveness and the delayed tachyphylaxis, respectively, to serotonin in the SHR kidney.
Persistent Identifierhttp://hdl.handle.net/10722/171012
ISSN
2015 Impact Factor: 5.062
2015 SCImago Journal Rankings: 2.193
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTuncer, Men_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:49Z-
dc.date.available2012-10-30T06:11:49Z-
dc.date.issued1991en_US
dc.identifier.citationJournal Of Hypertension, 1991, v. 9 n. 7, p. 623-629en_US
dc.identifier.issn0263-6352en_US
dc.identifier.urihttp://hdl.handle.net/10722/171012-
dc.description.abstractThe isolated and perfused kidney of the spontaneously hypertensive rat (SHR) exhibits an increased vascular reactivity and a delayed tachyphylaxis to serotonin (5-hydroxytryptamine) when compared with normotensive Wistar-Kyoto (WKY) rats. Experiments were designed to determine the involvement of products of cyclooxygenase in the augmented response and delayed tachyphylaxis to serotonin in the SHR kidney. Kidneys taken from male, 4-month-old SHR and WKY rats were studied in parallel and perfused with Tyrode's solution at constant, optimal flow rates. Vasoconstrictor responses were recorded as increases in perfusion pressure. The vasoconstrictor responses to serotonin, norepinephrine and angiotensin II were exaggerated in the SHR kidney compared with that of the WKY rat. Indomethacin did not affect the responsiveness to serotonin in the kidney of the SHR but increased the responses to the higher doses of the monoamine in the kidney of the WKY rats. Indomethacin accelerated the tachyphylaxis to serotonin in the SHR but delayed it in the WKY rats. Dazoxiben did not alter the responses to serotonin in the SHR. Responses to norepinephrine in the kidneys from both strains were not affected by indomethacin. The inhibitor of cyclooxygenase reduced the responses to angiotensin II in the kidneys from both hypertensive and normotensive animals. The basal and stimulated (serotonin, norepinephrine and angiotensin II) release of prostaglandins were measured by radioimmunoassay. The basal release of prostacyclin was lower, but that of thromboxane A 2 higher, in the kidneys of SHR compared with those of WKY rats. These experiments suggest that a reduced release of vasodilator prostanoid and the increased release of a vasoconstrictor product of cyclooxygenase may contribute to the increased responsiveness and the delayed tachyphylaxis, respectively, to serotonin in the SHR kidney.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jhypertension.com/en_US
dc.relation.ispartofJournal of Hypertensionen_US
dc.subject.meshAngiotensin Ii - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArachidonic Acids - Secretionen_US
dc.subject.meshDinoprost - Secretionen_US
dc.subject.meshDinoprostone - Secretionen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEpoprostenol - Secretionen_US
dc.subject.meshHypertension - Physiopathologyen_US
dc.subject.meshIndomethacin - Pharmacologyen_US
dc.subject.meshKidney - Drug Effectsen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Shren_US
dc.subject.meshRats, Inbred Wkyen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.subject.meshTachyphylaxis - Physiologyen_US
dc.subject.meshThromboxane A2 - Secretionen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.titleRole of prostanoids in the increased vascular responsiveness and delayed tachyphylaxis to serotonin in the kidney of spontaneously hypertensive ratsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00004872-199107000-00007-
dc.identifier.pmid1653798-
dc.identifier.scopuseid_2-s2.0-0025893047en_US
dc.identifier.volume9en_US
dc.identifier.issue7en_US
dc.identifier.spage623en_US
dc.identifier.epage629en_US
dc.identifier.isiWOS:A1991FX60000007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridTuncer, M=55226796700en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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