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Article: The calcium channel antagonist S 11568 causes endothelium-dependent relaxation in canine arteries

TitleThe calcium channel antagonist S 11568 causes endothelium-dependent relaxation in canine arteries
Authors
Issue Date1991
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1991, v. 197 n. 1, p. 41-48 How to Cite?
AbstractThe new dihydropyridine calcium channel antagonist S 11568 and its optical isomers, S 12967 and S 12968 (3 x 10-6 to 10-4 M), caused, unlike nifedipine (10-4 M), equipotent and rapid endothelium-dependent relaxations and increased the content of cyclic GMP in rings of canine femoral arteries. These effects were observed in the presence of indomethacin and were prevented by methylene blue, hemoglobin and N(G)-monomethyl-L-arginine. Thus these effects must involve endothelium-derived relaxing factor (EDRF) and be distinct from the calcium channel antagonistic effect, which is stereoselective and of slow onset. The compounds did not potentiate relaxations of rings without endothelium to nitric oxide. In bioassay experiments, the compounds produced endothelium-dependent relaxation only when applied to endothelial donors. These results are compatible with an increased release of EDRF induced by the dihydropyridine compounds.
Persistent Identifierhttp://hdl.handle.net/10722/171010
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVilaine, JPen_US
dc.contributor.authorBiondi, MLen_US
dc.contributor.authorVilleneuve, Nen_US
dc.contributor.authorFeletou, Men_US
dc.contributor.authorPeglion, JLen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:49Z-
dc.date.available2012-10-30T06:11:49Z-
dc.date.issued1991en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1991, v. 197 n. 1, p. 41-48en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/171010-
dc.description.abstractThe new dihydropyridine calcium channel antagonist S 11568 and its optical isomers, S 12967 and S 12968 (3 x 10-6 to 10-4 M), caused, unlike nifedipine (10-4 M), equipotent and rapid endothelium-dependent relaxations and increased the content of cyclic GMP in rings of canine femoral arteries. These effects were observed in the presence of indomethacin and were prevented by methylene blue, hemoglobin and N(G)-monomethyl-L-arginine. Thus these effects must involve endothelium-derived relaxing factor (EDRF) and be distinct from the calcium channel antagonistic effect, which is stereoselective and of slow onset. The compounds did not potentiate relaxations of rings without endothelium to nitric oxide. In bioassay experiments, the compounds produced endothelium-dependent relaxation only when applied to endothelial donors. These results are compatible with an increased release of EDRF induced by the dihydropyridine compounds.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArginine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshCalcium Channel Blockers - Pharmacologyen_US
dc.subject.meshCyclic Gmp - Metabolismen_US
dc.subject.meshDihydropyridines - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelium, Vascular - Metabolism - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHemoglobins - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMethylene Blue - Pharmacologyen_US
dc.subject.meshMuscle Relaxation - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Metabolismen_US
dc.subject.meshNitric Oxide - Pharmacologyen_US
dc.subject.meshOmega-N-Methylarginineen_US
dc.titleThe calcium channel antagonist S 11568 causes endothelium-dependent relaxation in canine arteriesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-2999(91)90362-T-
dc.identifier.pmid1654260-
dc.identifier.scopuseid_2-s2.0-0025854892en_US
dc.identifier.volume197en_US
dc.identifier.issue1en_US
dc.identifier.spage41en_US
dc.identifier.epage48en_US
dc.identifier.isiWOS:A1991FN11000006-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridVilaine, JP=7004617134en_US
dc.identifier.scopusauthoridBiondi, ML=7005127265en_US
dc.identifier.scopusauthoridVilleneuve, N=7003458215en_US
dc.identifier.scopusauthoridFeletou, M=7006461826en_US
dc.identifier.scopusauthoridPeglion, JL=7003361098en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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