File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1093/ajh/3.11.876
- Scopus: eid_2-s2.0-0025611631
- PMID: 2175626
- WOS: WOS:A1990EJ79700012
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Evidences for the existence of endothelium-derived relaxing factor in the renal medulla
Title | Evidences for the existence of endothelium-derived relaxing factor in the renal medulla |
---|---|
Authors | |
Keywords | CGMP, acetylcholine Endothelium-derived relaxing factor Renal medulla |
Issue Date | 1990 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjhyper |
Citation | American Journal Of Hypertension, 1990, v. 3 n. 11, p. 876-878 How to Cite? |
Abstract | The basal levels of cGMP in renal medulla slices were enhanced when the slices were stimulated with both endothelium-dependent (acetylcholine) and endothelium-independent (molsidomine) vasodilators. When preincubated with N(G)-monomethyl-L-arginine, a specific inhibitor of endothelium-derived relaxing factor, only the acetylcholine-stimulated increase was completely abolished. Furthermore, a preincubation with L-arginine, a selective precursor of endothelium-derived relaxing factor, enhanced the cGMP levels. The results indicate that the renal medulla, presumably the endothelial cells of the vasa recta, is able to produce endothelium-derived relaxing factor. |
Persistent Identifier | http://hdl.handle.net/10722/170996 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 0.925 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Biondi, ML | en_US |
dc.contributor.author | Dousa, T | en_US |
dc.contributor.author | Vanhoutte, P | en_US |
dc.contributor.author | Romero, JC | en_US |
dc.date.accessioned | 2012-10-30T06:11:46Z | - |
dc.date.available | 2012-10-30T06:11:46Z | - |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | American Journal Of Hypertension, 1990, v. 3 n. 11, p. 876-878 | en_US |
dc.identifier.issn | 0895-7061 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170996 | - |
dc.description.abstract | The basal levels of cGMP in renal medulla slices were enhanced when the slices were stimulated with both endothelium-dependent (acetylcholine) and endothelium-independent (molsidomine) vasodilators. When preincubated with N(G)-monomethyl-L-arginine, a specific inhibitor of endothelium-derived relaxing factor, only the acetylcholine-stimulated increase was completely abolished. Furthermore, a preincubation with L-arginine, a selective precursor of endothelium-derived relaxing factor, enhanced the cGMP levels. The results indicate that the renal medulla, presumably the endothelial cells of the vasa recta, is able to produce endothelium-derived relaxing factor. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjhyper | en_US |
dc.relation.ispartof | American Journal of Hypertension | en_US |
dc.subject | CGMP, acetylcholine | - |
dc.subject | Endothelium-derived relaxing factor | - |
dc.subject | Renal medulla | - |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Arginine - Analogs & Derivatives - Pharmacology | en_US |
dc.subject.mesh | Cyclic Gmp - Analysis - Metabolism | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Kidney Medulla - Chemistry - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Molsidomine - Pharmacology | en_US |
dc.subject.mesh | Nitric Oxide - Antagonists & Inhibitors - Metabolism | en_US |
dc.subject.mesh | Premedication | en_US |
dc.subject.mesh | Omega-N-Methylarginine | en_US |
dc.title | Evidences for the existence of endothelium-derived relaxing factor in the renal medulla | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, P:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, P=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1093/ajh/3.11.876 | - |
dc.identifier.pmid | 2175626 | - |
dc.identifier.scopus | eid_2-s2.0-0025611631 | en_US |
dc.identifier.volume | 3 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.spage | 876 | en_US |
dc.identifier.epage | 878 | en_US |
dc.identifier.isi | WOS:A1990EJ79700012 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Biondi, ML=7005127265 | en_US |
dc.identifier.scopusauthorid | Dousa, T=35510540700 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, P=7202304247 | en_US |
dc.identifier.scopusauthorid | Romero, JC=7402018868 | en_US |
dc.identifier.issnl | 0895-7061 | - |