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Article: Differential effects of the antianginal drug nicorandil on canine arteries and veins

TitleDifferential effects of the antianginal drug nicorandil on canine arteries and veins
Authors
Issue Date1990
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1990, v. 15 n. 5, p. 791-798 How to Cite?
AbstractNicorandil, a potent coronary vasorelaxant used in the treatment of angina, has differental effects on arteries and veins in vivo. To explain this phenomenon, experiments were designed to characterize the relaxant and inhibitory actions of this compound on canine isolated arteries and veins. Paired rings of canine coronary, femoral, and saphenous arteries and saphenous veins were suspended at optimal length for isometric tension recording in organ chambers containing physiologic salt solution at 37°C and gassed with 95% O2-5% CO2. In certain experiments, one ring of each pair was denuded of the endothelium. Removal of the endothelium did not affect nicorandil-induced relaxations of contracted blood vessels. Nicorandil exerted a differential relaxant effect on arteries and veins contracted with KCl (order of potency: saphenous vein > coronary artery > femoral artery). No difference in sensitivity to nicorandil was observed in arteries and veins contracted with prostaglandin F(2α). Contractions of saphenous arteries and veins to norepinephrine (NE) were equally sensitive to the inhibitory action of nicorandil. However, contractions of saphenous veins induced by sympathetic nerve stimulation were more sensitive to nicorandil than were contractions of saphenous arteries. Furthermore, nicorandil did not affect contractions to phenylephrine in saphenous veins, although contractions to B-HT 920 were virtually abolished by the compound. Saphenous veins contracted with St 587 were more sensitive to the relaxant action of nicorandil than when contracted with phenylephrine. These results suggest that nicorandil inhibits preferentially contractions of canine arteries and veins mediated by α2- rather than α1-adrenoceptors. This selectivity of action may be conferred by a differential receptor reserve and/or receptor coupling efficiency between the α-adrenoceptor subtypes for contractile agonists.
Persistent Identifierhttp://hdl.handle.net/10722/170993
ISSN
2015 Impact Factor: 2.462
2015 SCImago Journal Rankings: 0.962
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMorrison, KJen_US
dc.contributor.authorFlavahan, NAen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:45Z-
dc.date.available2012-10-30T06:11:45Z-
dc.date.issued1990en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1990, v. 15 n. 5, p. 791-798en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170993-
dc.description.abstractNicorandil, a potent coronary vasorelaxant used in the treatment of angina, has differental effects on arteries and veins in vivo. To explain this phenomenon, experiments were designed to characterize the relaxant and inhibitory actions of this compound on canine isolated arteries and veins. Paired rings of canine coronary, femoral, and saphenous arteries and saphenous veins were suspended at optimal length for isometric tension recording in organ chambers containing physiologic salt solution at 37°C and gassed with 95% O2-5% CO2. In certain experiments, one ring of each pair was denuded of the endothelium. Removal of the endothelium did not affect nicorandil-induced relaxations of contracted blood vessels. Nicorandil exerted a differential relaxant effect on arteries and veins contracted with KCl (order of potency: saphenous vein > coronary artery > femoral artery). No difference in sensitivity to nicorandil was observed in arteries and veins contracted with prostaglandin F(2α). Contractions of saphenous arteries and veins to norepinephrine (NE) were equally sensitive to the inhibitory action of nicorandil. However, contractions of saphenous veins induced by sympathetic nerve stimulation were more sensitive to nicorandil than were contractions of saphenous arteries. Furthermore, nicorandil did not affect contractions to phenylephrine in saphenous veins, although contractions to B-HT 920 were virtually abolished by the compound. Saphenous veins contracted with St 587 were more sensitive to the relaxant action of nicorandil than when contracted with phenylephrine. These results suggest that nicorandil inhibits preferentially contractions of canine arteries and veins mediated by α2- rather than α1-adrenoceptors. This selectivity of action may be conferred by a differential receptor reserve and/or receptor coupling efficiency between the α-adrenoceptor subtypes for contractile agonists.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAdrenergic Alpha-Agonists - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArteries - Drug Effectsen_US
dc.subject.meshAzepines - Pharmacologyen_US
dc.subject.meshDinoprost - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshEndothelium, Vascular - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshNiacinamide - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshNicorandilen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshPhenylephrine - Pharmacologyen_US
dc.subject.meshSympathetic Nervous System - Drug Effectsen_US
dc.subject.meshSynaptic Transmission - Drug Effectsen_US
dc.subject.meshVasodilator Agents - Pharmacologyen_US
dc.subject.meshVeins - Drug Effectsen_US
dc.titleDifferential effects of the antianginal drug nicorandil on canine arteries and veinsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005344-199005000-00015-
dc.identifier.pmid1692940en_US
dc.identifier.scopuseid_2-s2.0-0025355780en_US
dc.identifier.volume15en_US
dc.identifier.issue5en_US
dc.identifier.spage791en_US
dc.identifier.epage798en_US
dc.identifier.isiWOS:A1990DA55200015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMorrison, KJ=7102484828en_US
dc.identifier.scopusauthoridFlavahan, NA=7006398882en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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