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Article: Effects of the potassium channel activator, BRL 34915, on the action potential characteristics of canine cardiac Purkinje fibers

TitleEffects of the potassium channel activator, BRL 34915, on the action potential characteristics of canine cardiac Purkinje fibers
Authors
Issue Date1990
PublisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org
Citation
Journal Of Pharmacology And Experimental Therapeutics, 1990, v. 253 n. 3, p. 1090-1096 How to Cite?
AbstractThe effects of various concentrations (1-100 μM) of BRL 34915 on the action potential characteristics were investigated in normal canine Purkinje fibers and Purkinje fibers surviving infarction. For comparison, the electrophysiological effects of BRL 34915 were also examined in normal Purkinje fibers in which the potassium conductance had been reduced by barium. In normal Purkinje fibers, BRL 34915 produced a concentration-dependent shortening of action potential duration (APD) without change in the maximum diastolic potential, action potential amplitude or maximum upstroke velocity. A similar shortening of APD was observed in Purkinje fibers surviving infarction and in barium-treated Purkinje fibers. The reduction of APD by BRL 34915 was more pronounced at a longer cycle length of stimulation than at a shorter cycle length. In normal Purkinje fibers and in Purkinje fibers surviving infarction, depolarizations produced by low external potassium (1 mM) were attenuated by the drug, whereas there were little or no effects on high potassium (4-8 mM)-induced depolarization. Barium-treated Purkinje fibers when depolarized by 1 mM potassium were not sensitive to the hyperpolarizing effect of BRL 34915. It is proposed that the unique electrophysiological activity of BRL 34915 in canine Purkinje fibers is related to an increase in the potassium currents, i(x1), i(k1), and the ATP-sensitive potassium current in these fibers.
Persistent Identifierhttp://hdl.handle.net/10722/170991
ISSN
2015 Impact Factor: 3.76
2015 SCImago Journal Rankings: 1.847
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBril, Aen_US
dc.contributor.authorMan, RYKen_US
dc.date.accessioned2012-10-30T06:11:44Z-
dc.date.available2012-10-30T06:11:44Z-
dc.date.issued1990en_US
dc.identifier.citationJournal Of Pharmacology And Experimental Therapeutics, 1990, v. 253 n. 3, p. 1090-1096en_US
dc.identifier.issn0022-3565en_US
dc.identifier.urihttp://hdl.handle.net/10722/170991-
dc.description.abstractThe effects of various concentrations (1-100 μM) of BRL 34915 on the action potential characteristics were investigated in normal canine Purkinje fibers and Purkinje fibers surviving infarction. For comparison, the electrophysiological effects of BRL 34915 were also examined in normal Purkinje fibers in which the potassium conductance had been reduced by barium. In normal Purkinje fibers, BRL 34915 produced a concentration-dependent shortening of action potential duration (APD) without change in the maximum diastolic potential, action potential amplitude or maximum upstroke velocity. A similar shortening of APD was observed in Purkinje fibers surviving infarction and in barium-treated Purkinje fibers. The reduction of APD by BRL 34915 was more pronounced at a longer cycle length of stimulation than at a shorter cycle length. In normal Purkinje fibers and in Purkinje fibers surviving infarction, depolarizations produced by low external potassium (1 mM) were attenuated by the drug, whereas there were little or no effects on high potassium (4-8 mM)-induced depolarization. Barium-treated Purkinje fibers when depolarized by 1 mM potassium were not sensitive to the hyperpolarizing effect of BRL 34915. It is proposed that the unique electrophysiological activity of BRL 34915 in canine Purkinje fibers is related to an increase in the potassium currents, i(x1), i(k1), and the ATP-sensitive potassium current in these fibers.en_US
dc.languageengen_US
dc.publisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.orgen_US
dc.relation.ispartofJournal of Pharmacology and Experimental Therapeuticsen_US
dc.subject.meshAction Potentials - Drug Effectsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntihypertensive Agents - Pharmacologyen_US
dc.subject.meshBarium - Pharmacologyen_US
dc.subject.meshBenzopyrans - Pharmacologyen_US
dc.subject.meshCromakalimen_US
dc.subject.meshDogsen_US
dc.subject.meshElectrophysiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Conduction System - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Potentials - Drug Effectsen_US
dc.subject.meshPotassium Channels - Drug Effectsen_US
dc.subject.meshPurkinje Fibers - Drug Effectsen_US
dc.subject.meshPyrroles - Pharmacologyen_US
dc.titleEffects of the potassium channel activator, BRL 34915, on the action potential characteristics of canine cardiac Purkinje fibersen_US
dc.typeArticleen_US
dc.identifier.emailMan, RYK:rykman@hkucc.hku.hken_US
dc.identifier.authorityMan, RYK=rp00236en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2359018-
dc.identifier.scopuseid_2-s2.0-0025339799en_US
dc.identifier.volume253en_US
dc.identifier.issue3en_US
dc.identifier.spage1090en_US
dc.identifier.epage1096en_US
dc.identifier.isiWOS:A1990DK70200027-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridBril, A=8982060800en_US
dc.identifier.scopusauthoridMan, RYK=7004986435en_US

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