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- Publisher Website: 10.1161/01.CIR.81.6.1921
- Scopus: eid_2-s2.0-0025302487
- PMID: 2344684
- WOS: WOS:A1990DH02100021
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Article: Long-term impairment of endothelium-dependent relaxations to aggregating platelets after reperfusion injury in canine coronary arteries
Title | Long-term impairment of endothelium-dependent relaxations to aggregating platelets after reperfusion injury in canine coronary arteries |
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Authors | |
Keywords | Ischemia Thrombins Thrombosis Vasospasm |
Issue Date | 1990 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org |
Citation | Circulation, 1990, v. 81 n. 6, p. 1921-1927 How to Cite? |
Abstract | Experiments were designed and performed to determine whether endothelial function remained chronically impaired after coronary artery reperfusion. Canine left anterior descending coronary arteries were exposed to ischemia (60 minutes) followed by reperfusion (12 weeks). Rings (3-4 mm wide) of the reperfused artery and of normal left circumflex (control) coronary artery segments were suspended in organ chambers containing physiological saline solution (37°C, gassed with 95% O2-5% CO2) for isometric force measurement. Endothelium-independent contractions to KCl or prostaglandin F(2α) and endothelium-independent relaxations to nitric oxide or isoproterenol were comparable in control and chronically reperfused arteries. However, chronically reperfused coronary arteries exhibited impaired endothelium-dependent relaxations to aggregating platelets. In addition, the reperfused coronary arteries exhibited impaired endothelium-dependent relaxations to the platelet-derived compounds adenosine diphosphate, serotonin, and thrombin. However, the endothelium-dependent relaxations to acetylcholine were comparable between control and reperfused arteries. Thus, after 12 weeks of reperfusion, previously occluded coronary arteries exhibited a selective impairment of endothelium-dependent relaxation evoked by aggregating platelets. In vivo, this phenomenon could favor platelet adhesion, aggregation, and platelet-induced contraction of coronary smooth muscle and thus facilitate ischemic events such as vasospasm and coronary thrombosis. |
Persistent Identifier | http://hdl.handle.net/10722/170987 |
ISSN | 2023 Impact Factor: 35.5 2023 SCImago Journal Rankings: 8.415 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Pearson, PJ | en_US |
dc.contributor.author | Schaff, HV | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:44Z | - |
dc.date.available | 2012-10-30T06:11:44Z | - |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Circulation, 1990, v. 81 n. 6, p. 1921-1927 | en_US |
dc.identifier.issn | 0009-7322 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170987 | - |
dc.description.abstract | Experiments were designed and performed to determine whether endothelial function remained chronically impaired after coronary artery reperfusion. Canine left anterior descending coronary arteries were exposed to ischemia (60 minutes) followed by reperfusion (12 weeks). Rings (3-4 mm wide) of the reperfused artery and of normal left circumflex (control) coronary artery segments were suspended in organ chambers containing physiological saline solution (37°C, gassed with 95% O2-5% CO2) for isometric force measurement. Endothelium-independent contractions to KCl or prostaglandin F(2α) and endothelium-independent relaxations to nitric oxide or isoproterenol were comparable in control and chronically reperfused arteries. However, chronically reperfused coronary arteries exhibited impaired endothelium-dependent relaxations to aggregating platelets. In addition, the reperfused coronary arteries exhibited impaired endothelium-dependent relaxations to the platelet-derived compounds adenosine diphosphate, serotonin, and thrombin. However, the endothelium-dependent relaxations to acetylcholine were comparable between control and reperfused arteries. Thus, after 12 weeks of reperfusion, previously occluded coronary arteries exhibited a selective impairment of endothelium-dependent relaxation evoked by aggregating platelets. In vivo, this phenomenon could favor platelet adhesion, aggregation, and platelet-induced contraction of coronary smooth muscle and thus facilitate ischemic events such as vasospasm and coronary thrombosis. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org | en_US |
dc.relation.ispartof | Circulation | en_US |
dc.subject | Ischemia | - |
dc.subject | Thrombins | - |
dc.subject | Thrombosis | - |
dc.subject | Vasospasm | - |
dc.subject.mesh | Adenosine Diphosphate - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Coronary Vessels - Drug Effects - Physiopathology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endothelium, Vascular - Drug Effects - Physiology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Myocardial Reperfusion Injury - Physiopathology | en_US |
dc.subject.mesh | Platelet Aggregation - Physiology | en_US |
dc.subject.mesh | Potassium Chloride - Pharmacology | en_US |
dc.subject.mesh | Prostaglandins F - Pharmacology | en_US |
dc.subject.mesh | Serotonin - Pharmacology | en_US |
dc.subject.mesh | Thrombin - Pharmacology | en_US |
dc.subject.mesh | Vasodilation - Drug Effects - Physiology | en_US |
dc.title | Long-term impairment of endothelium-dependent relaxations to aggregating platelets after reperfusion injury in canine coronary arteries | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1161/01.CIR.81.6.1921 | - |
dc.identifier.pmid | 2344684 | - |
dc.identifier.scopus | eid_2-s2.0-0025302487 | en_US |
dc.identifier.volume | 81 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 1921 | en_US |
dc.identifier.epage | 1927 | en_US |
dc.identifier.isi | WOS:A1990DH02100021 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Pearson, PJ=7202175749 | en_US |
dc.identifier.scopusauthorid | Schaff, HV=36041155600 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0009-7322 | - |