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Article: Fentanyl is devoid of major effects on coronary vasoreactivity and myocardial metabolism in experimental animals

TitleFentanyl is devoid of major effects on coronary vasoreactivity and myocardial metabolism in experimental animals
Authors
Issue Date1990
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.anesthesiology.org
Citation
Anesthesiology, 1990, v. 72 n. 3, p. 535-541 How to Cite?
AbstractExperiments were designed to determine the effects of fentanyl on coronary vascular tone and energetic state of the heart. Both arterial and arteriolar responses were assessed; particular attention was directed to epicardial vessels. Four experimental methods and three animal species were used. Isolated canine coronary artery rings with and without endothelium were suspended in organ chambers, and changes in their tension were measured. Fentanyl (100 ng/ml) had no effect on resting tension of unstimulated rings on a contraction evoked by serotonin 10-8 to 10-4 M. In rings with endothelium, the opioid had a minimal depressant effect on the contractile response to phenylephrine. Tension of vessels precontracted with serotonin (3 x 10-7 M), or phenylephrine (10-5 M) was unchanged following fentanyl at 10, 30, 70, or 150 ng/ml. Computerized quantitative angiography was used in intact pigs anesthetized with ketamine to determine the effects of fentanyl on coronary artery diameters of vessels with or without endothelium. Intravenous fentanyl 50 and 250 μg/kg had no effect on vessel diameters. Isolated perfused rat hearts were used to assess fentanyl effects upon coronary flow and arteriolar tone and upon myocardial energy state. Coronary blood flow was not altered by fentanyl (100 ng/ml) and was unchanged following washout of the drug. The heart maintained a normal energy status prior to and following fentanyl treatment. These data demonstrate that, under the conditions tested, fentanyl is devoid of major effects on the coronary circulation and upon myocardial metabolism.
Persistent Identifierhttp://hdl.handle.net/10722/170983
ISSN
2015 Impact Factor: 5.264
2015 SCImago Journal Rankings: 2.162
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBlaise, GAen_US
dc.contributor.authorWitzeling, TMen_US
dc.contributor.authorSill, JCen_US
dc.contributor.authorVinay, Pen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:43Z-
dc.date.available2012-10-30T06:11:43Z-
dc.date.issued1990en_US
dc.identifier.citationAnesthesiology, 1990, v. 72 n. 3, p. 535-541en_US
dc.identifier.issn0003-3022en_US
dc.identifier.urihttp://hdl.handle.net/10722/170983-
dc.description.abstractExperiments were designed to determine the effects of fentanyl on coronary vascular tone and energetic state of the heart. Both arterial and arteriolar responses were assessed; particular attention was directed to epicardial vessels. Four experimental methods and three animal species were used. Isolated canine coronary artery rings with and without endothelium were suspended in organ chambers, and changes in their tension were measured. Fentanyl (100 ng/ml) had no effect on resting tension of unstimulated rings on a contraction evoked by serotonin 10-8 to 10-4 M. In rings with endothelium, the opioid had a minimal depressant effect on the contractile response to phenylephrine. Tension of vessels precontracted with serotonin (3 x 10-7 M), or phenylephrine (10-5 M) was unchanged following fentanyl at 10, 30, 70, or 150 ng/ml. Computerized quantitative angiography was used in intact pigs anesthetized with ketamine to determine the effects of fentanyl on coronary artery diameters of vessels with or without endothelium. Intravenous fentanyl 50 and 250 μg/kg had no effect on vessel diameters. Isolated perfused rat hearts were used to assess fentanyl effects upon coronary flow and arteriolar tone and upon myocardial energy state. Coronary blood flow was not altered by fentanyl (100 ng/ml) and was unchanged following washout of the drug. The heart maintained a normal energy status prior to and following fentanyl treatment. These data demonstrate that, under the conditions tested, fentanyl is devoid of major effects on the coronary circulation and upon myocardial metabolism.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.anesthesiology.orgen_US
dc.relation.ispartofAnesthesiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCoronary Circulation - Drug Effectsen_US
dc.subject.meshCoronary Vessels - Drug Effectsen_US
dc.subject.meshDogsen_US
dc.subject.meshEnergy Metabolism - Drug Effectsen_US
dc.subject.meshFentanyl - Pharmacologyen_US
dc.subject.meshMyocardium - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshSwineen_US
dc.titleFentanyl is devoid of major effects on coronary vasoreactivity and myocardial metabolism in experimental animalsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00000542-199003000-00023-
dc.identifier.pmid2310036-
dc.identifier.scopuseid_2-s2.0-0025232498en_US
dc.identifier.volume72en_US
dc.identifier.issue3en_US
dc.identifier.spage535en_US
dc.identifier.epage541en_US
dc.identifier.isiWOS:A1990CR16600023-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridBlaise, GA=7005522049en_US
dc.identifier.scopusauthoridWitzeling, TM=6506265476en_US
dc.identifier.scopusauthoridSill, JC=7003810915en_US
dc.identifier.scopusauthoridVinay, P=7006438365en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US

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